Cynthia K. Harris

Systematic “Head‐to‐Head” Comparison of Scalp Biopsy Techniques for Alopecia Diagnosis: Diagnostic Adequacy, Efficiency, and Resource Utilization

Lauren E. Heusinkveld, Cynthia K. Harris, Timothy Walsh, William Anim et autres

BACKGROUND: Alopecia can significantly affect a patient's quality of life, underscoring the clinical importance of the optimal scalp biopsy technique. As histopathology remains the gold standard, selecting the most efficient and resource-conscious biopsy processing technique is essential for delivering high-value care. The …

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National Association of Medical Examiners Position Paper

James Gill, Elizabeth A. Bundock, Kristinza W. Giese, Cynthia K. Harris et autres

The National Association of Medical Examiners (NAME) convened a panel to create a position paper for the investigation of pediatric deaths due to suspected inflicted head trauma. The certification of both the cause and manner of death is dependent upon an evaluation …

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Cardiac genetic test yields and genotype-phenotype correlations from large cohort investigated by medical examiner's office

Sarah Saxton, Amy Kontorovich, Dawei Wang, Bo Zhou et autres

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Case 8-2024: A 55-Year-Old Man with Cardiac Arrest, Cardiogenic Shock, and Hypoxemia

Robert O. Roswell, Man Piu Wong, Ada C. Stefanescu Schmidt, Milena Petranović et autres

A 55-year-old man had an out-of-hospital cardiac arrest. An evaluation showed 2-mm ST-segment elevations in the inferior leads on electrocardiography, cardiogenic shock, and a new systolic murmur. A diagnosis was made.

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Pathology and Monkeypox virus Localization in Tissues From Immunocompromised Patients With Severe or Fatal Mpox

Jana M. Ritter, Roosecelis B. Martines, Julu Bhatnagar, Agam K. Rao et autres

BACKGROUND: Pathology and Monkeypox virus (MPXV) tissue tropism in severe and fatal human mpox is not thoroughly described but can help elucidate the disease pathogenesis and the role of coinfections in immunocompromised patients. METHODS: We analyzed biopsy and autopsy tissues from 22 …

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Engineered immunogens to elicit antibodies against conserved coronavirus epitopes

Saunders K.O., Yin Q., Katie L. Winters, M. Barr et autres

Immune responses to SARS-CoV-2 primarily target the receptor binding domain of the spike protein, which continually mutates to escape acquired immunity. Other regions in the spike S2 subunit, such as the stem helix and the segment encompassing residues 815-823 adjacent to the …

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The next phase in patient safety education: Towards a standardized, tools-based pathology patient safety curriculum

Cynthia K. Harris, Yigu Chen, Erin L. J. Alston, Ali Brown et autres

Patient safety education is a mandated Common Program Requirement of the Accreditation Council for Graduate Medical Education and for the Royal College of Physicians and Surgeons of Canada in all medical residency and fellowship programs. Although many hospitals and healthcare environments have …

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Case 9-2023: A 20-Year-Old Man with Shortness of Breath and Proteinuria

Shaun F. Fitzgerald, Teresa Victoria, Weizhen Tan, Cynthia K. Harris

A 20-year-old man was admitted with hemoptysis and hypoxemia. CT of the chest revealed pulmonary emboli; urinalysis showed proteinuria and hematuria. Diagnostic tests were performed.

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The Eyes Have It: How Critical are Ophthalmic Findings to the Diagnosis of Pediatric Abusive Head Trauma?

Cynthia K. Harris, Anna M. Stagner

Pediatric abusive head trauma (AHT), still colloquially known as shaken baby syndrome, is a leading cause of morbidity and mortality among infants. Controversy has grown surrounding this diagnosis, and the specificity of the clinical findings-subdural hemorrhage, cerebral edema, and retinal hemorrhages-has been …

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Pseudomonas species may appear strikingly filamentous in tissue sections: an important consideration for surgical pathologists and a reminder of the utility of modified silver impregnation methods

Cynthia K. Harris, Bianca B. Christensen, Melanie C. Kwan, Ruth K. Foreman et autres

Although tissue culture is the gold standard for diagnosing infection, histologic examination of surgically resected tissue can be a critical component in the diagnosis of tissue infection. The goal of this brief report is to alert surgical pathologists that Pseudomonas species can …

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Prioritizing Patient Safety and Minimizing Waste: Institutional Review of Cases and a Proposed Process for Designing a Surgical Pathology Gross-Only Examination Policy

Cynthia K. Harris, Alexander Pyden, Allison M. Onken, Benjamin Yarsky et autres

OBJECTIVES: Gross-only examination policies vary widely across pathology departments. Several studies-particularly a College of American Pathologists' Q-Probes study-have looked at the variations in gross-only policies, and even more studies have addressed the (in)appropriateness of certain specimen types for gross-only examination. Few, if …

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Patient‐facing communication for cytopathologists: A framework for disclosing diagnostic error

Cynthia K. Harris, Caitlin M. Darrell, Paul A. VanderLaan, Yael Heher

Medical errors are a major source of harm to patients. Regulatory bodies mandate and patient safety experts advocate the disclosure of medical errors to patients to promote transparency and to create accountability for improving health care processes. Although pathologists regularly report errors-either …

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