Ricardo Iglésio

Regional, functional and transcriptomic decoding of multidimensional brain structure alterations in obsessive-compulsive disorder

ENIGMA-OCD Working Group, Leonardo Cardoso Saraiva, João R. Sato, Isaac Sebenius et autres

Studies of brain morphology in mental illness often focus on a few neuroimaging phenotypes. Here we present a comprehensive morphological characterization in obsessive-compulsive disorder (OCD) in a large sample (2255 OCD, 2264 controls) using nine cortical and four subcortical phenotypes, including several …

Safety and Feasibility of Low-Intensity Transcranial Focused Ultrasound Targeting the Anterior Thalamus

Glaucia Aline Nunes, Josimar Reis Ortiz, Cláudia Mingrone, Débora Arnaut et autres

Low-intensity transcranial focused ultrasound (tFUS) is a novel noninvasive neuromodulation technique capable of reaching deep brain structures with high spatial precision. The anterior thalamus, a key relay in pain processing, is a promising target for modulating central pain networks. In this context, …

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Regional, functional and transcriptomic decoding of multidimensional brain structure alterations in obsessive-compulsive disorder

Leonardo Cardoso Saraiva, João R. Sato, Isaac Sebenius, Nadža Džinalija et autres

Abstract Studies of brain morphology in mental illness often focus on a few neuroimaging phenotypes. Here we present a comprehensive morphological characterization in obsessive-compulsive disorder (OCD) in a large sample (2255 OCD, 2264 controls) using nine cortical and four subcortical phenotypes, including …

Field H1 of Forel vs Subthalamic Nucleus Electrical Stimulation in Parkinson’s Disease: Long-Term Effects on Motor Symptoms and Quality of Life

Fabio Luiz Francheschi Godinho, Ricardo Iglésio, Kaito Alves Carvalho Laube, Juliana Rodrigues

Introduction: Deep brain stimulation (DBS) of the subthalamic nucleus (STN) relieves motor symptoms, including levodopa- responsive gait disorders in Parkinson’s disease (PD). Traditionally, STN-DBS is not indicated to treat severe, clinically resistant axial symptoms. In this scenario, field H1 of Forel (FF) …

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Connectivity Analysis of Brain Circuits Modulated by Electrical Stimulation of the Ventral Capsule and Ventral Striatum in Patients with Obsessive-Compulsive Disorder

Kaito Alves Carvalho Laube, Ricardo Iglésio, Paula Ricci Arantes, Eurı́pedes Constantino Miguel et autres

Introduction: Deep brain stimulation (DBS) targeting the ventral capsule/ventral striatum (VC/VS) is an emerging treatment for treatment-resistant obsessive-compulsive disorder (OCD). However, approximately 40% of patients fail to achieve significant symptom relief. Variability in clinical outcomes may reflect individual diferences in the modulation …

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Surgical Treatment of Holmes Tremor: Case Report, Systematic Review, and Meta-Analysis

Juliana Rodrigues, Kaito Alves Carvalho Laube, Murillo Martins Correia, Rubens Gisbert Cury et autres

Introduction: Holmes Tremor (HT) is a rare, disabling, low-frequency tremor tipically arising from brainstem lesions. Pharmacological treatments often fail to provide sufficient relief, leading to the use of surgical strategies, particularly deep brain stimulation (DBS) and lesional procedures. This study presents a …

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Parkinson’s Disease and Neurotechnology: Emerging Surgical Approaches and Perspectives for the Next Decade

Ricardo Iglésio, Fabio Luiz Francheschi Godinho

Introduction: Parkinson’s disease (PD) is a progressive neurodegenerative disorder affecting motor and non-motor functions. In advanced or treatment-resistant cases, surgical strategies such as deep brain stimulation (DBS) and MR-guided focused ultrasound (MRgFUS) offer substantial symptomatic relief. With recent progress in neurotechnology, biomedical …

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Insula Deep Brain Stimulation for Neuropathic Pain: A Cross-Over, Randomized, Sham-Controlled Trial

Liu Dongyang, Pedro Henrique Martins da Cunha, Jorge Dornellys da Silva Lapa, Gabriel Taricani Kubota et autres

OBJECTIVE: Despite neuropathic pain affecting a significant portion of the population, many people still experience refractory conditions. Here, we evaluated the efficacy and safety of posterior-superior insula deep brain stimulation for pharmaco-resistant neuropathic pain. MATERIALS AND METHODS: This was a phase 2 …

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Case Report: Cardiac myxomas and Carney complex: a case of recurrent embolic strokes and intracranial tumor growth

Aliny Weber Kuhn, Antônio Marcondes Lerário, A. Morais, Ricardo Iglésio et autres

Cardiac myxomas, though rare, are the most common benign cardiac tumors and may be associated with Carney Complex (CNC). Patients with CNC are at increased risk of developing recurrent myxomas, which can lead to severe complications. We report a case of a …

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Intraoperative recordings from the posterior superior insula in awake humans with peripheral neuropathic pain

Raíssa Benocci Thibes, Pedro Henrique Martins da Cunha, Jorge Dornellys da Silva Lapa, Liu Dongyang et autres

BACKGROUND AND OBJECTIVES: The activity profile of the posterior insula in neuropathic pain (NeP) remains largely unexplored. To address this and examine its modulation by somatosensory stimulation, we recorded local field potentials (LFP) in awake patients with NeP undergoing deep brain stimulation …

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Open Thoracic Anterolateral Cordotomy – Is There Still Room?

Carlos Alberto Miranda Lyra, Ângelo Marcel Santana Duarte Araujo, Dimas Fernandes Vasconcelos Júnior, Daniella Dias Silva Sá et autres

Introdução A dor do câncer envolve múltiplos mecanismos, caindo assim na classificação de dor mista. A cordotomia para dor oncológica é realizada há muito tempo, como uma técnica cirúrgica aberta ou uma abordagem percutânea. Objetivo Descrevemos aqui a aplicação bem-sucedida de uma …

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Sustained improvement of obsessive-compulsive symptoms following interruption of deep brain stimulation

Israel Aristides de Carvalho Filho, Marcelo Q. Hoexter, Fabio Luiz Francheschi Godinho, Ricardo Iglésio et autres

A 59-year-old male with severe treatment-resistant OCD achieved sustained symptom improvement after discontinuing deep brain stimulation (DBS) for over four years. Despite partial relief with ventral capsule/ventral striatum (VC/VS) DBS, complications led to device removal in 2018. Remarkably, the patient remained largely …

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