Gabriel Taricani Kubota

Non-invasive neuromodulation for neuropathic pain: an evidence-informed clinical roadmap proposal

Rafael Jardim Duarte‐Moreira, Tiago da Silva Lopes, Ana Mércia Fernandes, Fuad Ahmad Hazime et autres

BACKGROUND: Non-invasive neuromodulation has shown analgesic effects in neuropathic pain (NeP) but translating the available evidence into practical decisions regarding technique, target, and stimulation protocol remains challenging. OBJECTIVE: To develop an evidence-informed clinical roadmap to support decision-making for non-invasive neuromodulation in NeP …

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The Combination of Buprenorphine and Pregabalin in the Management of Peripheral Neuropathic Pain: A Phase IV , Randomized, Double‐Blind and Placebo‐Controlled Clinical Trial

Larissa I. Moreira, Pedro N. Martins, Manoel J. Teixeira, Daniel C. Andrade et autres

BACKGROUND: Pharmacological combinations are commonly used for treating refractory neuropathic pain, although supporting evidence is lacking. Gabapentinoid-opioid combination is one of the most studied; however, their efficacy is inconsistent across clinical trials. This trial investigated the feasibility, effectiveness and safety of adding …

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Safety and Feasibility of Low-Intensity Transcranial Focused Ultrasound Targeting the Anterior Thalamus

Glaucia Aline Nunes, Josimar Reis Ortiz, Cláudia Mingrone, Débora Arnaut et autres

Low-intensity transcranial focused ultrasound (tFUS) is a novel noninvasive neuromodulation technique capable of reaching deep brain structures with high spatial precision. The anterior thalamus, a key relay in pain processing, is a promising target for modulating central pain networks. In this context, …

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Concordância entre única medida e a média de três medidas do limiar de dor por pressão craniofacial: viabilidade em adultos saudáveis.

Rosana Tieka Miyazaki Brancucci, Vanda de Lelis, Georgia Westenhofen, Ida Fortini et autres

BackgroundPressure pain threshold assessment is used to quantify pain sensitivity in headache disorders, reflecting peripheral and central sensitization of the nociceptive system. Traditional protocols involve multiple measurements to ensure reliability, but these protocols are time-consuming and may cause participant fatigue and discomfort. …

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Amitriptyline for neuropathic pain in patients with leprosy: a bicenter randomized controlled trial

Jorge Alberto Martins Pentiado Júnior, Gabriel Taricani Kubota, Larissa Iulle Moreira, Ana Mércia Fernandes et autres

ABSTRACT: In this bicenter, randomized, double-blind, placebo-controlled trial, we evaluated the effectiveness and safety of amitriptyline as an add-on therapy for leprosy-related neuropathic pain. A total of 117 participants were randomly assigned to receive amitriptyline or placebo for 9 weeks. The primary …

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Leprosy-related pain: updates and why it matters

Matthew Evans, Pentiado Júnior Jorge Alberto Martins, Gabriel Taricani Kubota, Andrew S.C. Rice et autres

Leprosy is a chronic infection that mainly affects the skin and the distal portions of the peripheral nervous system.86 The latest figures from the World Health Organization (WHO) indicate a continued decline in global leprosy incidence, with 172,717 new cases reported worldwide …

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EV213 REPETITIVE MAGNETIC STIMULATION OF THE POSTERIOR SUPERIOR INSULA COMPARED TO THE PRIMARY MOTOR AREA FOR TREATMENT OF PERIPHERAL NEUROPATHIC PAIN: DOUBLE-BLIND RANDOMIZED CLINICAL TRIAL

Tamara Maria Ribeiro Pereira, Gabriel Taricani Kubota, Alessandra Fonseca, Daniel Andrade et autres

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Decision Making for Non-Invasive Neuromodulation Prescription in the Treatment of Neuropathic Pain: A Roadmap

Rafael Jardim Duarte Moreira, Tiago S. Lopes, A. O. N. G Fernandes, Fuad Ahmad Hazime et autres

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Correlações entre estimativas não-invasivas da pressão intracraniana, parâmetros clínicos, e pressão de abertura da punção lombar entre pacientes ambulatoriais

Gabriel Taricani Kubota

Introdução: A pressão intracraniana (PIC) é um parâmetro importante para o diagnóstico e planejamento terapêutico de um leque de doenças neurológicas. No contexto ambulatorial, ela é rotineiramente avaliada através da punção lombar (PL). Contudo, este procedimento pode não ser diagnóstico em uma …

The cortical mechanisms underlying the analgesic effects of repetitive transcranial magnetic stimulation: protocol for a systematic review and meta-analysis

Nahian Shahmat Chowdhury, Wei-Ju Chang, Negin Hesam‐Shariati, Yann Quidé et autres

INTRODUCTION: Repetitive transcranial magnetic stimulation (rTMS) is a promising, safe, and non-invasive treatment for pain. However, there is no clear understanding of the cortical mechanisms underlying the analgesic effect of rTMS. One theory is that rTMS-induced analgesia is associated with alterations in …

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Investigation of predictors of pain relief with high-frequency repetitive motor cortex transcranial magnetic stimulation among people with fibromyalgia

Catarina Cöuras Lins, Pedro Nascimento Martins, Ana Mércia Fernandes, Abrahão Fontes Baptista et autres

OBJECTIVES: To identify baseline predictors of clinical response to the primary motor cortex high-frequency repetitive transcranial magnetic stimulation (M1 HF-rTMS) in patients with fibromyalgia. MATERIALS AND METHODS: We performed a secondary analysis of 32 women with fibromyalgia from a randomized, double-blind, sham-controlled …

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Embodied Interoception Questionnaire (Intero-10): development, validation, and application in people with chronic pain

Ana Mércia Fernandes, Vinícius Rosa Oliveira, Samantha K. Millard, Pedro S. Martins et autres

Abstract Embodied interoception refers to the perception of the body’s state and is a multidimensional cognitive process. It is proposed that the experience of pain also feeds interoceptive networks with information from the state of the body, and the subjective experience of …

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