Jenny C. Link

X chromosome dosage drives statin-induced dysglycemia and mitochondrial dysfunction

Peixiang Zhang, Joseph J. Munier, Carrie B. Wiese, Laurent Vergnes et autres

Statin drugs lower blood cholesterol levels for cardiovascular disease prevention. Women are more likely than men to experience adverse statin effects, particularly new-onset diabetes (NOD) and muscle weakness. Here we find that impaired glucose homeostasis and muscle weakness in statin-treated female mice …

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The metabolite α-ketobutyrate increases health and life spans by activating AMPK

Chieh Chen, Brett Lomenick, Min Chai, Wilson Huang et autres

Abstract Aging is a complex process that is directly related to human health and disease. The extraordinary finding that aging is malleable, as shown in model organisms whose life and health spans are extended by specific gene mutations or dietary or pharmacological …

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X chromosome dosage drives statin-induced dysglycemia and mitochondrial dysfunction

Peixiang Zhang, Joseph J. Munier, Laurent Vergnes, Carrie B. Wiese et autres

Summary Statin drugs lower blood cholesterol levels for cardiovascular disease prevention. Women are more likely than men to experience adverse statin effects, particularly new-onset diabetes (NOD) and muscle weakness. We determined that female mice are more susceptible than males to glucose intolerance, …

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X chromosome dosage of histone demethylase KDM5C determines sex differences in adiposity

Jenny C. Link, Carrie B. Wiese, Xuqi Chen, Rozeta Avetisyan et autres

Males and females differ in body composition and fat distribution. Using a mouse model that segregates gonadal sex (ovaries and testes) from chromosomal sex (XX and XY), we showed that XX chromosome complement in combination with a high-fat diet led to enhanced …

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Transcriptome Analysis of Mice Treated with Anti‐miR‐144

Vivian Iloabuchi, Tyler Laws, Jenny C. Link, Thomas Q. de Aguiar Vallim et autres

Heart disease is a leading cause of death each year in the United States. In this study, we investigated the regulation of reverse cholesterol transport, a process shown to attenuate heart disease. Our lab has previously shown that mice treated with anti‐miR‐144 …

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A MAFG-lncRNA axis links systemic nutrient abundance to hepatic glucose metabolism

Marta Pradas-Juni, Nils Rouven Hansmeier, Jenny C. Link, Elena B. Schmidt et autres

Obesity and type 2 diabetes mellitus are global emergencies and long noncoding RNAs (lncRNAs) are regulatory transcripts with elusive functions in metabolism. Here we show that a high fraction of lncRNAs, but not protein-coding mRNAs, are repressed during diet-induced obesity (DIO) and …

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Genetic Basis for Sex Differences in Obesity and Lipid Metabolism

Jenny C. Link, Karen Reue

Men and women exhibit significant differences in obesity, cardiovascular disease, and diabetes. To provide better diagnosis and treatment for both sexes, it is important to identify factors that underlie the observed sex differences. Traditionally, sex differences have been attributed to the differential …

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Diet, gonadal sex, and sex chromosome complement influence white adipose tissue miRNA expression

Jenny C. Link, Yehudit Hasin-Brumshtein, Rita M. Cantor, Xuqi Chen et autres

BACKGROUND: MicroRNAs (miRNAs) are small non-coding RNA molecules that regulate gene expression by targeting specific mRNA species for degradation or interfering with translation. Specific miRNAs are key regulators of adipogenesis, and are expressed at different levels in adipose tissue from lean and …

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Additional file 1: of Diet, gonadal sex, and sex chromosome complement influence white adipose tissue miRNA expression

Jenny C. Link, Yehudit Hasin-Brumshtein, Rita M. Cantor, Xuqi Chen et autres

1007 mature miRNA sequences that mapped uniquely to the miRBase 18. (TXT 15Â kb)

Additional file 3: of Diet, gonadal sex, and sex chromosome complement influence white adipose tissue miRNA expression

Jenny C. Link, Yehudit Hasin-Brumshtein, Rita M. Cantor, Xuqi Chen et autres

7 cases of miRNAs that were of unequal length, and thus read counts had to be adjusted for non-unique mapping. (TXT 364)

Additional file 2: of Diet, gonadal sex, and sex chromosome complement influence white adipose tissue miRNA expression

Jenny C. Link, Yehudit Hasin-Brumshtein, Rita M. Cantor, Xuqi Chen et autres

256 miRNAs that mapped to 82 unique sequences. (TXT 5Â kb)

Additional file 4: of Diet, gonadal sex, and sex chromosome complement influence white adipose tissue miRNA expression

Jenny C. Link, Yehudit Hasin-Brumshtein, Rita M. Cantor, Xuqi Chen et autres

Count table summarizing read counts for 1841 mature and precursor miRNA sequences in fifteen sequencing libraries. Perfectly matched counts are normalized to total library reads per million. (XLS 512Â kb)