Chae-Yeong An

Discovery of undescribed PCSK9 inhibitory activities in Annonaceous acetogenins from Polyalthia evecta

Chae-Yeong An, Chan Woong Park, Pisey Pel, Piseth Khiev et autres

kr, Éthiopie, kh, pr (code pays fourni par la source)

Cycloartane-type triterpenoids from Combretum quadrangulare (Combretaceae) and their potential for the treatment of hypercholesterolemia

Chae-Yeong An, Pisey Pel, Young‐Won Chin

kr (code pays fourni par la source)

3′-Oxo-dihydrophaseic Alcohol and Norisoprenoids from Combretum quadrangulare with Cytotoxicity against Human Liver Cancer Cells

Chae-Yeong An, Chan‐Woong Park, Pisey Pel, Hyun-Suk Lee et autres

A new 3ʹ-oxo-dihydrophaseic alcohol (1), along with three known norisoprenoids (2–4), was isolated from the 70% ethanol extract of the aerial parts of Combretum quadrangulare through repeated column chromatography. The structure of the new compound was elucidated using extensive spectroscopic methods, including …

Cycloartane-type triterpenoids from Combretum quadrangulare Kurz with PCSK9 secretion inhibitory activities

Chae-Yeong An, Pisey Pel, Mingoo Bae, Chan‐Woong Park et autres

kr, vn, pr (code pays fourni par la source)

Chemical constituents from the roots of Cynanchum wilfordii with PCSK9 secretion inhibitory activities

Min-Gyung Son, Pisey Pel, Chae-Yeong An, Chan‐Woong Park et autres

kr, pr (code pays fourni par la source)

Dihydrostilbenes and flavonoids from whole plants of Jacobaea vulgaris

Shinae Lee, Min-Gyung Son, Young‐Mi Kim, Chae-Yeong An et autres

kr, mn, pr (code pays fourni par la source)

Stereochemical assignment of clerodane-type diterpenes from the fruits of Casearia grewiifolia and their ability to inhibit PCSK9 expression

Piseth Nhoek, Chae-Yeong An, Min-Gyung Son, Hee‐Sung Chae et autres

kr, kh, pr (code pays fourni par la source)

Acyclic Triterpenoids from Alpinia katsumadai Seeds with Proprotein Convertase Subtilisin/Kexin Type 9 Expression and Secretion Inhibitory Activity

Chae-Yeong An, Min-Gyung Son, Young‐Won Chin

High Resolution Image Download MS PowerPoint Slide Cholesterol is one of the primary causes of cardiovascular disease. Investigating and developing potential drugs to effectively treat hypercholesterolemia are therefore of critical importance. Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors have been developed to …

kr (code pays fourni par la source)

Chemical constituents from Morus alba with proprotein convertase subtilisin/kexin type 9 expression and secretion inhibitory activity

Hongic Won, Min-Gyung Son, Pisey Pel, Piseth Nhoek et autres

for LDLR, PCSK9 and IDOL mRNA regulatory activity, and it was found that betulinic acid (13) showed the most potent effect on downregulation of PCSK9 and upregulation of LDLR at both mRNA and protein levels, showing comparable results to berberine, the positive …

kr (code pays fourni par la source)

Isocoumarins and Benzoquinones with Their Proprotein Convertase Subtilisin/Kexin Type 9 Expression Inhibitory Activities from Dried Roots of Lysimachia vulgaris

Pisey Pel, Young‐Mi Kim, Hyun Ji Kim, Piseth Nhoek et autres

High Resolution Image Download MS PowerPoint Slide A phytochemical investigation of the n -hexane-soluble chemical constituents of Lysimachia vulgaris roots allowed for selection using a proprotein convertase subtilisin-kexin type 9 (PCSK9) mRNA expression monitoring assay in HepG2 cells. This led to the …

kr (code pays fourni par la source)

Chemical Constituents from the Roots and Rhizomes of Sophora tonkinensis and Their Effects on Proprotein Convertase Substilisin/Kexin Type 9 Expression

Pisey Pel, Hee‐Sung Chae, Piseth Nhoek, Young‐Mi Kim et autres

High Resolution Image Download MS PowerPoint Slide This study was conducted to further investigate bioactive molecules from Sophora tonkinensis that can inhibit proprotein convertase substilisin/kexin type 9 (PCSK9) expression. After interpreting NMR spectroscopic data and MS spectral data of all isolates, a …

kr (code pays fourni par la source)

Chemical Constituents from Agrimonia pilosa with Inhibitory Activity against Interleukin 1β Production via NLRP3 and NLRC4 Inflammasomes

Piseth Nhoek, Hee‐Sung Chae, Chae-Yeong An, Pisey Pel et autres

Bioactivity-guided fractionation by preliminary screening using interleukin-1β production in lipopolysaccharides (LPS)-induced J774A.1 cell line led to the isolation of fourteen structures including chromone, isocoumarins, flavanoids, and triterpenes from the aerial part of Agrimonia pilosa Ledeb. All structures were determined by measuring their …