Giuseppe Pintucci

Supplementary Figure 1 from TGF-β1 Induces Endothelial Cell Apoptosis by Shifting VEGF Activation of p38MAPK from the Prosurvival p38β to Proapoptotic p38α

Giovanni Maria Ferrari, Vitaly Terushkin, Martin J. Wolff, Xiaodong Zhang et autres

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Supplementary Figure 1 from TGF-β1 Induces Endothelial Cell Apoptosis by Shifting VEGF Activation of p38MAPK from the Prosurvival p38β to Proapoptotic p38α

Giovanni Maria Ferrari, Vitaly Terushkin, Martin J. Wolff, Xiaodong Zhang et autres

PDF file - 51K

Data from TGF-β1 Induces Endothelial Cell Apoptosis by Shifting VEGF Activation of p38MAPK from the Prosurvival p38β to Proapoptotic p38α

Giovanni Maria Ferrari, Vitaly Terushkin, Martin J. Wolff, Xiaodong Zhang et autres

Abstract TGF-β1 and VEGF, both angiogenesis inducers, have opposing effects on vascular endothelial cells. TGF-β1 induces apoptosis; VEGF induces survival. We have previously shown that TGF-β1 induces endothelial cell expression of VEGF, which mediates TGF-β1 induction of apoptosis through activation of p38 …

Data from TGF-β1 Induces Endothelial Cell Apoptosis by Shifting VEGF Activation of p38MAPK from the Prosurvival p38β to Proapoptotic p38α

Giovanni Maria Ferrari, Vitaly Terushkin, Martin J. Wolff, Xiaodong Zhang et autres

Abstract TGF-β1 and VEGF, both angiogenesis inducers, have opposing effects on vascular endothelial cells. TGF-β1 induces apoptosis; VEGF induces survival. We have previously shown that TGF-β1 induces endothelial cell expression of VEGF, which mediates TGF-β1 induction of apoptosis through activation of p38 …

TGF-β1 Induces Endothelial Cell Apoptosis by Shifting VEGF Activation of p38MAPK from the Prosurvival p38β to Proapoptotic p38α

Giovanni Maria Ferrari, Vitaly Terushkin, Martin J. Wolff, Xiaodong Zhang et autres

TGF-β1 and VEGF, both angiogenesis inducers, have opposing effects on vascular endothelial cells. TGF-β1 induces apoptosis; VEGF induces survival. We have previously shown that TGF-β1 induces endothelial cell expression of VEGF, which mediates TGF-β1 induction of apoptosis through activation of p38 mitogen-activated …

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The cardiovascular effects of proteolysis of high molecular weight basic fibroblast growth factor by inflammatory serine proteases

Giuseppe Pintucci

Cardiovascular disease is characterized by structural and functional changes of blood vessel’s wall that lead to reduced blood flow and eventually occlusion. The integrity of the vascular wall is maintained by homeostatic mechanisms controlled by the endothelium. Stress caused by age, oxidants, …

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Mitral Valve Prolapse Gene Expression Profiling: A Microarray Study

David G. Greenhouse, Anthony Murphy, Giuseppe Pintucci, Paolo Mignatti et autres

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Protein targets of inflammatory serine proteases and cardiovascular disease

Ram Sharony, Pey‐Jen Yu, Joy Park, Aubrey C. Galloway et autres

Serine proteases are a key component of the inflammatory response as they are discharged from activated leukocytes and mast cells or generated through the coagulation cascade. Their enzymatic activity plays a major role in the body's defense mechanisms but it has also …

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Correlation between plasma osteopontin levels and aortic valve calcification: Potential insights into the pathogenesis of aortic valve calcification and stenosis

Pey‐Jen Yu, Adam H. Skolnick, Giovanni Maria Ferrari, Katherine Heretis et autres

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Transforming growth factor‐beta 1 (TGF‐β1) induces angiogenesis through vascular endothelial growth factor (VEGF)‐mediated apoptosis

Giovanni Maria Ferrari, Brandoch D. Cook, Vitaly Terushkin, Giuseppe Pintucci et autres

VEGF and TGF-beta1 induce angiogenesis but have opposing effects on endothelial cells. VEGF protects endothelial cells from apoptosis; TGF-beta1 induces apoptosis. We have previously shown that VEGF/VEGF receptor-2 (VEGFR2) signaling mediates TGF-beta1 induction of apoptosis. This finding raised an important question: Does …

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Inhibition of Mitogen-Activated Protein Kinases (MAPKs) as a Strategy to Prevent Intimal Hyperplasia Following Cardiovascular Interventions

Luigi Pirelli, Pey‐Jen Yu, Iosif M. Gulkarov, Aubrey C. Galloway et autres

TGF‐β1 induces rearrangement of FLK‐1–VE‐cadherin–β‐catenin complex at the adherens junction through VEGF‐mediated signaling

Brandoch D. Cook, Giovanni Maria Ferrari, Giuseppe Pintucci, Paolo Mignatti

VEGF and TGF-beta1 induce angiogenesis but have opposing effects on vascular endothelial cells: VEGF promotes survival; TGF-beta1 induces apoptosis. We have previously shown that TGF-beta1 induces endothelial cell apoptosis via up-regulation of VEGF expression and activation of signaling through VEGF receptor-2 (flk-1). …

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