Timing Liu

Investigating misclassification of type 1 diabetes in a population-based cohort of British Pakistanis and Bangladeshis using polygenic risk scores

Timing Liu, Alagu Sankareswaran, Gordon Paterson, Shaheen Akhtar et autres

Correct classification of type 1 (T1D) and type 2 diabetes (T2D) is challenging due to overlapping clinical features and the increasingly early onset of T2D, particularly in South Asians. Polygenic risk scores (PRSs) for T1D and T2D have been shown to work …

gb, in, au (code pays fourni par la source)

Quantifying Changes on OCT in Eyes Receiving Treatment for Neovascular Age-Related Macular Degeneration

Gabriella Moraes, Robbert Struyven, Siegfried K. Wagner, Timing Liu et autres

Purpose: Application of artificial intelligence (AI) to macular OCT scans to segment and quantify volumetric change in anatomical and pathological features during intravitreal treatment for neovascular age-related macular degeneration (AMD). Design: Retrospective analysis of OCT images from the Moorfields Eye Hospital AMD …

gb, us (code pays fourni par la source)

Development and validation of an automated machine learning model for the multi-class classification of diabetic retinopathy, central retinal vein occlusion and branch retinal vein occlusion based on color fundus photographs

Carolyn Yu Tung Wong, Timing Liu, Tin Lik Wong, Justin Man Kit Tong et autres

Automated machine learning (AutoML) is a novel artificial intelligence (AI) strategy that enables clinicians without coding experience to develop their own AI models. This study assessed the discriminative performance of AutoML in differentiating diabetic retinopathy (DR), central retinal vein occlusion (CRVO) and …

gb, hk (code pays fourni par la source)

Impact of definitions on continence outcomes in a series of 1000 robot‐assisted radical prostatectomies, time for an internationally agreed definition?

Mahmoud Abuelnaga, Rasha Gendy, Mark Yao, Curtis Phelan et autres

Table S1 Baseline characteristics of the study cohort. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for …

gb, Égypte (code pays fourni par la source)

Comparing code-free and bespoke deep learning approaches in ophthalmology

Carolyn Yu Tung Wong, Ciara O’Byrne, Priyal Taribagil, Timing Liu et autres

AIM: Code-free deep learning (CFDL) allows clinicians without coding expertise to build high-quality artificial intelligence (AI) models without writing code. In this review, we comprehensively review the advantages that CFDL offers over bespoke expert-designed deep learning (DL). As exemplars, we use the …

gb, hk, ca (code pays fourni par la source)

Ocular Manifestations of the Oculocerebrorenal Syndrome of Lowe

Matthew Tran, Matthew A. Young, Timing Liu, Yang Sun

us, gb (code pays fourni par la source)

A foundation model for generalizable disease detection from retinal images

Yukun Zhou, Mark A. Chia, Siegfried K. Wagner, Murat Seçkin Ayhan et autres

Abstract Medical artificial intelligence (AI) offers great potential for recognizing signs of health conditions in retinal images and expediting the diagnosis of eye diseases and systemic disorders1. However, the development of AI models requires substantial annotation and models are usually task-specific with …

gb, es, us (code pays fourni par la source)

Investigating misclassification of type 1 diabetes in a population-based cohort of British Pakistanis and Bangladeshis using polygenic risk scores

Timing Liu, Alagu Sankareswaran, Gordon Paterson, Diane P. Fraser et autres

Abstract Aims Correct classification of type 1 (T1D) and type 2 diabetes (T2D) is challenging due to overlapping clinical features and the increasingly early onset of T2D, particularly in South Asians. We used polygenic risk scores (PRSs) in a British Bangladeshi and …

gb, in (code pays fourni par la source)

Predictors of 10-year Mortality After Hip Fracture Surgery in a Pre-Pandemic Cohort

Bryan D. Loh, Lei Jiang, Timing Liu, Naomi Kong et autres

Introduction: Though hip fractures are associated with significant mortality and morbidity, increasing life expectancy in developed countries necessitates an analysis of mortality trends and factors predicting long term survival. The aim of this study is to identify the predictors of 10-year mortality …

sg (code pays fourni par la source)

Third-Generation Single-Molecule Sequencing for Preimplantation Genetic Testing of Aneuploidy and Segmental Imbalances

Vivienne J. Tan, Timing Liu, Zainul Arifin, Beatrice Pak et autres

BACKGROUND: Current strategies for preimplantation genetic testing for aneuploidy or structural rearrangements (PGT-A/SR) rely mainly on next-generation sequencing (NGS) and microarray platforms, which are robust but require expensive instrumentation. We explored the suitability of third-generation single-molecule sequencing as a PGT-A/SR screening platform …

sg (code pays fourni par la source)

Association Between Retinal Features From Multimodal Imaging and Schizophrenia

Siegfried K. Wagner, Mario Cortina‐Borja, Steven M. Silverstein, Yukun Zhou et autres

Importance: The potential association of schizophrenia with distinct retinal changes is of clinical interest but has been challenging to investigate because of a lack of sufficiently large and detailed cohorts. Objective: To investigate the association between retinal biomarkers from multimodal imaging (oculomics) …

gb, us, es (code pays fourni par la source)

Simultaneous Screening of the FRAXA and FRAXE Loci for Rapid Detection of FMR1 CGG and/or AFF2 CCG Repeat Expansions by Triplet-Primed PCR

Timing Liu, Furene S. Wang, Felicia Sh Cheah, Yanghong Gu et autres

Moderate to hyper-expansion of trinucleotide repeats at the FRAXA and FRAXE fragile sites, with or without concurrent hypermethylation, has been associated with intellectual disability and other conditions. Unlike molecular diagnosis of FMR1 CGG repeat expansions in FRAXA, current detection of AFF2 CCG …

sg, us, au (code pays fourni par la source)