Association Between Retinal Features From Multimodal Imaging and Schizophrenia
Rattachement africain : gb, us, es. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Importance: The potential association of schizophrenia with distinct retinal changes is of clinical interest but has been challenging to investigate because of a lack of sufficiently large and detailed cohorts. Objective: To investigate the association between retinal biomarkers from multimodal imaging (oculomics) and schizophrenia in a large real-world population. Design, Setting, and Participants: This cross-sectional analysis used data from a retrospective cohort of 154 830 patients 40 years and older from the AlzEye study, which linked ophthalmic data with hospital admission data across England. Patients attended Moorfields Eye Hospital, a secondary care ophthalmic hospital with a principal central site, 4 district hubs, and 5 satellite clinics in and around London, United Kingdom, and had retinal imaging during the study period (January 2008 and April 2018). Data were analyzed from January 2022 to July 2022. Main Outcomes and Measures: Retinovascular and optic nerve indices were computed from color fundus photography. Macular retinal nerve fiber layer (RNFL) and ganglion cell-inner plexiform layer (mGC-IPL) thicknesses were extracted from optical coherence tomography. Linear mixed-effects models were used to examine the association between schizophrenia and retinal biomarkers. Results: A total of 485 individuals (747 eyes) with schizophrenia (mean [SD] age, 64.9 years [12.2]; 258 [53.2%] female) and 100 931 individuals (165 400 eyes) without schizophrenia (mean age, 65.9 years [13.7]; 53 253 [52.8%] female) were included after images underwent quality control and potentially confounding conditions were excluded. Individuals with schizophrenia were more likely to have hypertension (407 [83.9%] vs 49 971 [48.0%]) and diabetes (364 [75.1%] vs 28 762 [27.6%]). The schizophrenia group had thinner mGC-IPL (-4.05 μm, 95% CI, -5.40 to -2.69; P = 5.4 × 10-9), which persisted when investigating only patients without diabetes (-3.99 μm; 95% CI, -6.67 to -1.30; P = .004) or just those 55 years and younger (-2.90 μm; 95% CI, -5.55 to -0.24; P = .03). On adjusted analysis, retinal fractal dimension among vascular variables was reduced in individuals with schizophrenia (-0.14 units; 95% CI, -0.22 to -0.05; P = .001), although this was not present when excluding patients with diabetes. Conclusions and Relevance: In this study, patients with schizophrenia had measurable differences in neural and vascular integrity of the retina. Differences in retinal vasculature were mostly secondary to the higher prevalence of diabetes and hypertension in patients with schizophrenia. The role of retinal features as adjunct outcomes in patients with schizophrenia warrants further investigation.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Association Between Retinal Features From Multimodal Imaging and Schizophrenia
- Date Crossref
- 01/05/2023
- Éditeur
- American Medical Association (AMA)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Moorfields Eye Hospital NHS Foundation Trust pays non établi dans la noticeÉtablissement de santé
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NIHR Moorfields Biomedical Research Centre pays non établi dans la noticeStructure de recherche
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Moorfields Eye Hospital pays non établi dans la noticeÉtablissement de santé
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University College London Institute of Ophthalmology pays non établi dans la noticeUniversité ou école supérieure
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Great Ormond Street Hospital pays non établi dans la noticeÉtablissement de santé
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University of Rochester Medicine Center for Visual Science pays non établi dans la noticeÉtablissement de santé
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University of Rochester Department of Neuroscience pays non établi dans la noticeUniversité ou école supérieure
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Mondragon Unibertsitatea pays non établi dans la noticeUniversité ou école supérieure
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University of Dundee pays non établi dans la noticeUniversité ou école supérieure
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University of Edinburgh Centre for Clinical Brain Sciences pays non établi dans la noticeUniversité ou école supérieure
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University Hospitals Birmingham NHS Foundation Trust pays non établi dans la noticeÉtablissement de santé
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NIHR Birmingham Biomedical Research Centre pays non établi dans la noticeStructure de recherche
Moorfields Eye Hospital NHS Foundation Trust, NIHR Moorfields Biomedical Research Centre et Moorfields Eye Hospital, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.