Yumiko Ninomiya

Clinical Impact of Genetic Testing for Long QT Syndrome ― Evidence From a Nationwide LQTS Registry in Japan ―

Takeshi Aiba, Seiko Ohno, Misa Takegami, Yoshiaki Kato et autres

BACKGROUND: Genetic testing for long QT syndrome (LQTS) is useful for diagnosis, risk stratification, and therapeutic strategies. This study investigated the clinical impact of genetic testing for LQTS patients. METHODS AND RESULTS: Total 3,851 patients (proband: 2,316 [60%]; female: 2,283 [59%]; median …

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Screening of 1-Month-Old Infants With Prolonged QT Interval and Its Cutoff Value

Masao Yoshinaga, Hiroya Ushinohama, Seiichi Sato, Seiko Ohno et autres

BACKGROUND: The prevalence of congenital long QT syndrome (LQTS) (1 : 2,000) is based on genetic testing and ECG data, but the prevalence of electrocardiographically determined prolonged corrected QT interval (pQTc) in infants is unclear. METHODS AND RESULTS: Subjects were 10,282 1-month-old …

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Efficacy of walking as a potential strategy to treat childhood obesity in the clinical setting

Yumiko Ninomiya, Sachie Sakimukai, Yoshiya Ito, Masao Yoshinaga

BACKGROUND: Walking is a common intervention for treating obesity in adults, but data on the effectiveness of walking for childhood obesity are limited. We therefore investigated the effectiveness of walking in the treatment of childhood obesity and the factors that make its …

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Holter Electrocardiographic Approach to Predicting Outcomes of Pediatric Patients With Long QT Syndrome

Masao Yoshinaga, Yumiko Ninomiya, Yuji Tanaka, Megumi Fukuyama et autres

BACKGROUND: This study was performed to clarify the clinical findings of pediatric patients diagnosed with long QT syndrome (LQTS) through electrocardiographic screening programs and to predict their outcome using Holter electrocardiographic approaches. METHODS AND RESULTS: This retrospective study included pediatric patients with …

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Anthracyclines for acute promyelocytic leukemia in a female with congenital long QT syndrome

Miku Kamimura, Takuro Nishikawa, Yoshihiro Takahashi, Jun Nagahama et autres

Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.

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P5376Tentative screening criteria for short QT interval among children and adolescents

Shinichiro Seki, Daisuke Hazeki, Yumiko Ninomiya, Kentaro Ueno et autres

Background: While the prevalence of short QT syndrome (SQTS) in children and adolescents is low, early detection is important because SQTS is associated with atrial or ventricular fibrillation and a propensity for cardiac arrest. In Japan, a school-based electrocardiogram (ECG) screening program …

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Tentative Screening Criteria for Short QT Interval in Children and Adolescents

Daisuke Hazeki, Yumiko Ninomiya, Kentaro Ueno, Masao Yoshinaga

BACKGROUND: While the prevalence of short QT syndrome (SQTS) in children and adolescents is low, early detection is important because SQTS can cause life-threatening arrhythmia. The aim of this study was to determine the tentative screening criteria for short QT interval in …

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A surviving 24-month-old patient with neonatal-onset carnitine palmitoyltransferase II deficiency

Naohiro Ikeda, Shinsuke Maruyama, K. Nakano, Ryo Imakiire et autres

The early-onset form of carnitine palmitoyltransferase (CPT) II deficiency has severe outcomes; patients typically die during the newborn period. We report a case of neonatal-onset CPT II deficiency with prolonged survival, exceeding 24 months. The patient was successfully treated by continuous hemodialysis …

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Disruption of Endothelial Cell Homeostasis Plays a Key Role in the Early Pathogenesis of Coronary Artery Abnormalities in Kawasaki Disease

Kentaro Ueno, Yumiko Ninomiya, Daisuke Hazeki, Kiminori Masuda et autres

Disruption of endothelial cell homeostasis may be associated with the pathogenesis of coronary artery abnormalities (CAA) in Kawasaki disease (KD). We sought to clarify the poorly understood pathogenic role of endothelial cell survival and death in KD vasculitis. Human umbilical vein endothelial …

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Dexmedetomidine is Associated with an Increased Incidence of Bradycardia in Patients with Trisomy 21 After Surgery for Congenital Heart Disease

Kentaro Ueno, Yumiko Ninomiya, Naohiro Shiokawa, Daisuke Hazeki et autres

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Potential risk factors for dexmedetomidine withdrawal seizures in infants after surgery for congenital heart disease

Yoshihiro Takahashi, Kentaro Ueno, Yumiko Ninomiya, Taisuke Eguchi et autres

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Abstract 97: Resistance Values in the Limbs are Useful for Estimating the Severity of Kawasaki Disease.

Yuichi Nomura, Kiminori Masuda, Yasuko Morita, Yumiko Ninomiya et autres

Vascular permeability is one of the characteristics of vasculitis in Kawasaki disease (KD) and is closely related to indurative edema. Evaluating indurative edema may be useful for estimating the severity of KD. Indurative edema is correlated with resistance values in the limbs. …

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