P5376Tentative screening criteria for short QT interval among children and adolescents

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Background: While the prevalence of short QT syndrome (SQTS) in children and adolescents is low, early detection is important because SQTS is associated with atrial or ventricular fibrillation and a propensity for cardiac arrest. In Japan, a school-based electrocardiogram (ECG) screening program has been conducted for 1st (6-year-old), 7th (12-year-old), and 10th (15-year-old) graders since 1994. This screening program has already helped detect a case of SQTS. Purpose: The present study was to determine the tentative screening criteria of short QT interval in children and adolescents with manually measured QTc values, using data obtained in the screening program conducted in our city. Methods: A total of 75,040 digitally stored electrocardiograms (ECGs) of participants in a school-based ECG screening program were obtained between 2009 and 2013. Based on the data obtained by automatic measurement, ECGs with a QTc value ≤10th percentile for each sex and grade were selected. Three consecutive QT/RR intervals of the selected ECGs were manually measured and corrected by Bazett's formula. The tentative screening criteria were developed for the estimated prevalence of SQTS, which was deduced based on the following facts and assumptions; 1) the probability of diagnosing long QT syndrome in the 7th graders is approximately 1/1000; 2) the numbers of patients with SQTS in the large series of articles was less than one thirtieth compared with those with LQTS; 3) exact numbers of patients with SQTS may be larger in future than now. Thus, the prevalence of SQTS was estimated to be between 1/30,000 and 1/10,000 in young subjects. To exclude the possibility of false negative results, we assumed that the prevalence of short QT interval was between 1/5,000 and 1/2,000.

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