Bin Jia

Extracellular Vesicle‐Transferred ATP‐Citrate Lyase Induces Monocyte Differentiation Toward Tumor‐Associated Macrophages and Fuels Hepatocellular Carcinoma Progression

Zhijun Liu, Haihong Lai, Qing Yang, Chaoyue Zhang et autres

Tumor-associated macrophages (TAMs) arise from monocytes and represent major contributors to the immunosuppressive microenvironment of solid tumors. However, the environmental cues that govern TAM differentiation and immunosuppressive activity remain incompletely understood. Here we demonstrate that hepatocellular carcinoma (HCC) cells secrete extracellular vesicles …

cn (code pays fourni par la source)

Activity-based protein profiling identifies dehydrodiisoeugenol as a novel ferroptosis inhibitor targeting ACSL4 to attenuate cisplatin-induced acute kidney injury

Fan Wu, Zhao Zhai, Guoli Sheng, Bin Jia et autres

cn, Éthiopie (code pays fourni par la source)

GW2 Interacts With OsPIP2;1 to Control Cell Division and Expansion in Rice

Chanjuan Ye, Dagang Chen, XinQiao Zhou, Jie Guo et autres

Summary statement This study demonstrates that GW2 overexpression causes non‐lethal pleiotropic defects and identifies aquaporin OsPIP2;1 as its potential target. GW2 interacts with OsPIP2;1 and establishes a novel regulatory module controlling grain size through modulation of water transport and photosynthetic efficiency.

cn (code pays fourni par la source)

Optimizing irrigation and nitrogen rates for sustainable wheat production: Balancing yield and nitrate leaching in a 7-year field study

Haoran Li, Bin Jia, Hongguang Wang, Dongxiao Li et autres

cn (code pays fourni par la source)

Expressing exogenous gene in Chlamydomonas reinhardtii chloroplast with viral replication elements

Yanan Jiang, Guiying Zhang, Song Wang, Ali Raza et autres

cn, bd (code pays fourni par la source)

AP1M2 Drives Gemcitabine‐Cisplatin Chemoresistance by Enhancing RAD54B ‐Associated DNA Repair in Bladder Cancer

Zehua Liu, Bolin Jia, Zhao Zhai, Fan Wu et autres

The combination of gemcitabine and cisplatin serves as a cornerstone in bladder cancer (BC) treatment, yet chemotherapy resistance continues to pose a significant challenge. This study utilizes a novel BC organoid model integrated with drug sensitivity assays to uncover the mechanisms underlying …

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An integrated proteomic classifier to distinguish benign from malignant pulmonary nodules

Bin Jia, Tingting Wang, Liangxuan Pan, Xiaoyao Du et autres

BACKGROUND: Pulmonary nodule with diameters ranging 8-30 mm has a high occurrence rate, and distinguishing benign from malignant nodules can greatly improve the patient outcome of lung cancer. However, sensitive and specific liquid-biopsy methods have yet to achieve satisfactory clinical goals. METHODS: …

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Engineering a complete mevalonate pathway in Chlamydomonas reinhardtii for enhanced isoprenoid production

Jingkai Wang, Muhammad Zohaib Anwar, Jiancheng Li, Dan Lin et autres

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A Rapid and Reversible Molecular “Switch” Regulating Protein Expression in Chlamydomonas reinhardtii

Xinyi Li, Song Wang, Qianyi Li, Xiangyu Li et autres

Chlamydomonas reinhardtii, a prominent chassis in synthetic biology, faces limitations in regulating the expression of exogenous genes. A destabilization domain (DD)/Shield-1 system, originally derived from mammals, offers a ligand-dependent control of stability, making it a valuable tool. This system utilises the destabilization …

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Successful establishment of an exogenous gene expression system in Chlamydomnas chloroplast based on viral replication elements

Yanan Jiang, Guiying Zhang, Song Wang, Ali Raza et autres

Abstract Currently, transformation in unicellular green alga ( Chlamydomonas reinhardtii ) chloroplast is hindered by a low yield of target products, possibly due to the heterogeneity of the chloroplast genome. In this study, an expression platform was established in C. reinhardtii by …

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N6-methyladenosine modification of hypoxia-inducible factor-1α regulates Helicobacter pylori-associated gastric cancer via the PI3K/AKT pathway

Tong-Yan An, Quan-Man Hu, Peng Ni, Yan-Qiao Hua et autres

BACKGROUND Helicobacter pylori (H. pylori ) colonizes the human gastric mucosa and is implicated in the development of gastric cancer (GC). The tumor microenvironment is characterized by hypoxia, where hypoxia-inducible factor-1α (HIF-1α) plays a key role as a transcription factor, but the …

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DNA Nanostructures Treat Inflammatory Bowel Disease through ROS Scavenging and Gut Microbiota Modulation

Jingru Ge, Bin Jia, Yuang Wang, Yuxuan Ma et autres

Abstract Inflammatory bowel disease (IBD) encompasses a collection of chronic inflammatory conditions impacting the gastrointestinal tract, with a discernible global rise in prevalence and severity. The overabundance of reactive oxygen species (ROS) in the intestinal environment leads disruption of local redox homeostasis, …

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