Agnieszka Brzozowska

Phosphorylation of the AP2 μ2 subunit by p70S6 kinase facilitates clathrin-mediated endocytosis

Aleksandra Tempes, Agnieszka Brzozowska, Tomasz Węgierski, Ayomide Fasemire et autres

Clathrin-mediated endocytosis (CME) internalizes cell-surface receptors via clathrin-coated invaginations of the plasma membrane. Both clathrin and endocytic cargo are recruited to these sites by the adaptor protein complex AP2. AP2 cycles between a closed cytoplasmic conformation and an open membrane-bound state, and …

pl, it, bg, hu (code pays fourni par la source)

Zika virus capsid protein C (ZIKV-C) interactors network mapped by proteomic analysis of human neural stem cells expressing FLAG-tagged C protein

Agata Malinowska, Magdalena Bakun, Agnieszka Brzozowska, Ewa Liszewska et autres

Abstract Zika virus is a teratogenic pathogen belonging to the Flaviviridae family. It possesses the ability to penetrate the placenta and affect the brain development of a fetus, resulting in microcephaly and functional impairments. Mechanisms of this neurotoxicity are still unclear, but …

pl, bg, us (code pays fourni par la source)

Phosphorylation of the AP2 μ2 subunit by p70S6 kinase facilitates clathrin-mediated endocytosis

Aleksandra Tempes, Agnieszka Brzozowska, Tomasz Węgierski, Katarzyna Olek et autres

Abstract Clathrin-mediated endocytosis (CME) internalizes cell-surface receptors via clathrin-coated invaginations of the plasma membrane. Both clathrin and endocytic cargo are recruited to these sites by the adaptor protein complex AP2. AP2 cycles between a closed cytoplasmic conformation and an open membrane-bound state, …

pl, us (code pays fourni par la source)

Autophagy initiation triggers p150Glued–AP-2β interaction on the lysosomes and facilitates their transport

Aleksandra Tempes, Karolina Bogusz, Agnieszka Brzozowska, Jan Węsławski et autres

Abstract The endocytic adaptor protein 2 (AP-2) complex binds dynactin as part of its noncanonical function, which is necessary for dynein-driven autophagosome transport along microtubules in neuronal axons. The absence of this AP-2-dependent transport causes neuronal morphology simplification and neurodegeneration. The mechanisms …

pl, us (code pays fourni par la source)

Rab11 regulates autophagy at dendritic spines in an mTOR- and NMDA-dependent manner

Aleksandra Janusz, Agnieszka Brzozowska, Aleksandra Tempes, Małgorzata Urbańska et autres

Synaptic plasticity is a process that shapes neuronal connections during neurodevelopment and learning and memory. Autophagy is a mechanism that allows the cell to degrade its unnecessary or dysfunctional components. Autophagosomes appear at dendritic spines in response to plasticity-inducing stimuli. Autophagy defects …

us, pl (code pays fourni par la source)

Autophagy initiation triggers p150 Glued -AP-2β interaction on the lysosomes to facilitate their transport

Aleksandra Tempes, Karolina Bogusz, Agnieszka Brzozowska, Jan Węsławski et autres

Abstract The endocytic adaptor protein 2 (AP-2) complex binds dynactin as part of its noncanonical function, which is necessary for dynein-driven autophagosome transport along microtubules in neuronal axons. The absence of this AP-2-dependent transport causes neuronal morphology simplification and neurodegeneration. The mechanisms …

pl, us (code pays fourni par la source)

Rab11 regulates autophagy at dendritic spines in an mTOR- and NMDA-dependent manner

Aleksandra Janusz, Agnieszka Brzozowska, Aleksandra Tempes, Małgorzata Urbańska et autres

Abstract Synaptic plasticity is a process that shapes neuronal connections during neurodevelopment, learning, and memory. Autophagy is a mechanism that allows cells to degrade their unnecessary or dysfunctional components. Autophagosomes appear at dendritic spines in response to plasticity-inducing stimuli. Autophagy defects contribute …

pl (code pays fourni par la source)

Role of dynein–dynactin complex, kinesins, motor adaptors, and their phosphorylation in dendritogenesis

Aleksandra Tempes, Jan Węsławski, Agnieszka Brzozowska, Jacek Jaworski

One of the characteristic features of different classes of neurons that is vital for their proper functioning within neuronal networks is the shape of their dendritic arbors. To properly develop dendritic trees, neurons need to accurately control the intracellular transport of various …

pl (code pays fourni par la source)

Inhibition of apoptosis in BHV-1-infected cells depends on Us3 serine/threonine kinase and its enzymatic activity

Agnieszka Brzozowska, Andrea D. Lipińska, Natalia Derewońko, Dorota Lesiak et autres

pl (code pays fourni par la source)

Immunogenicity and functional characterization of Leishmania-derived hepatitis C virus envelope glycoprotein complex

Katarzyna Grzyb, Anna Czarnota, Agnieszka Brzozowska, Anna Cieślik et autres

Hepatitis C virus (HCV) envelope glycoproteins E1 and E2 are the main inducers of a cross-neutralizing antibody response which plays an important role in the early phase of viral infection. Correctly folded and immunologically active E1E2 complex can be expressed in mammalian …

pl (code pays fourni par la source)

US3 - wielofunkcyjna kinaza serynowo-treoninowa alfaherpeswirusów

Dorota Lesiak, Agnieszka Brzozowska, Krystyna Bieńkowska-Szewczyk, Andrea D. Lipińska

pl (code pays fourni par la source)

Evasion of antiviral host responses by a multifunctional serine/threonine kinase of alphaherpesviruses

Dorota Bartoszewska, Agnieszka Brzozowska, Michał Rychłowski, Krystyna Bieńkowska-Szewczyk et autres

pl (code pays fourni par la source)