Krystyna Bieńkowska-Szewczyk

Minicircle-based vaccine induces potent T-cell and antibody responses against hepatitis C virus

Anna Czarnota, Aleksandra Raszplewicz, Aleksandra Sławińska, Krystyna Bieńkowska-Szewczyk et autres

An effective vaccine against hepatitis C virus (HCV) should elicit both humoral and cellular immune responses. Previously, we characterized a bivalent vaccine candidate against hepatitis B (HBV) and HCV using chimeric HBV-HCV virus-like particles (VLP), in which the highly conserved epitope of …

pl (code pays fourni par la source)

Alterations in N-glycosylation of HCV E2 Protein in Children Patients with IFN-RBV Therapy Failure

Karolina Zimmer, Alicja Chmielewska, Paulina Jackowiak, Marek Figlerowicz et autres

The glycosylation of viral envelope proteins plays an important role in virus biology and the immune response of the host to infection. Hepatitis C virus (HCV) envelope proteins E1 and E2, key players in virus entry and spread, are highly N-glycosylated and …

pl (code pays fourni par la source)

The herpesvirus UL49.5 protein hijacks a cellular C-degron pathway to drive TAP transporter degradation

Magda Wąchalska, Celeste Riepe, Magdalena J. Ślusarz, Małgorzata Graul et autres

The transporter associated with antigen processing (TAP) is a key player in the major histocompatibility class I-restricted antigen presentation and an attractive target for immune evasion by viruses. Bovine herpesvirus 1 impairs TAP-dependent antigenic peptide transport through a two-pronged mechanism in which …

pl, us (code pays fourni par la source)

The herpesvirus UL49.5 protein hijacks a cellular C-degron pathway to drive TAP transporter degradation

Magda Wąchalska, Celeste Riepe, Magdalena J. Ślusarz, Małgorzata Graul et autres

ABSTRACT The transporter associated with antigen processing (TAP) is a key player in the MHC class I-restricted antigen presentation and an attractive target for immune evasion by viruses. Bovine herpesvirus 1 (BoHV-1) impairs TAP-dependent antigenic peptide transport through a two-pronged mechanism in …

pl, us (code pays fourni par la source)

Effect of Glycan Shift on Antibodies against Hepatitis C Virus E2 412–425 Epitope Elicited by Chimeric sHBsAg-Based Virus-Like Particles

Anna Czarnota, Anna Offersgaard, Ania M. Owsianka, Garazi Peña Alzua et autres

Epitope I, located within amino acids 412 to 423 of the HCV E2 glycoprotein, is an important target for an epitope-based HCV vaccine. One interesting feature of epitope I is the N417 glycosylation site, where a single change to S417 or T417 …

pl, dk, gb (code pays fourni par la source)

The N-terminal Proline Hinge Motif Controls the Structure of Bovine Herpesvirus 1-encoded Inhibitor of the Transporter Associated with Antigen Processing Required for its Immunomodulatory Function

Małgorzata Graul, Natalia Karska, Magda Wąchalska, Paweł Krupa et autres

Due to unique features, proline residues may control protein structure and function. Here, we investigated the role of 52PPQ54 residues, indicated by the recently established experimental 3D structure of bovine herpesvirus 1-encoded UL49.5 protein as forming a characteristic proline hinge motif in …

pl (code pays fourni par la source)

Functional Analysis of a Frontal miRNA Cluster Located in the Large Latency Transcript of Pseudorabies Virus

Weronika Hoffmann, Andrea D. Lipińska, Krystyna Bieńkowska-Szewczyk

MicroRNAs (miRNAs) have been identified as a class of crucial regulators of virus-host crosstalk, modulating such processes as viral replication, antiviral immune response, viral latency, and pathogenesis. Pseudorabies virus (PRV), a model for the study of alphaherpesvirus biology, codes for 11 distinct …

pl (code pays fourni par la source)

The N-Terminal Proline Hinge Motif Controls the Structure of Bovine Herpesvirus 1-Encoded Inhibitor of the Transporter Associated with Antigen Processing Required for its Immunomodulatory Function

Małgorzata Graul, Natalia Karska, Magda Wąchalska, Paweł Krupa et autres

pl (code pays fourni par la source)

Zoonotic spill-over of SARS-CoV-2: mink-adapted virus in humans

Łukasz Rąbalski, Maciej Kosiński, Natalia Mazur-Panasiuk, Bogusław Szewczyk et autres

pl, fi (code pays fourni par la source)

Immune response against SARS-CoV-2 variants: the role of neutralization assays

Alicja Chmielewska, Anna Czarnota, Krystyna Bieńkowska-Szewczyk, Katarzyna Grzyb

Since the emergence of the novel coronavirus SARS-CoV-2 in late 2019, the COVID-19 pandemic has hindered social life and global economic activity. As of July 2021, SARS-CoV-2 has caused over four million deaths. The rapid spread and high mortality of the disease …

pl (code pays fourni par la source)

The Role of IFITM Proteins in Tick-Borne Encephalitis Virus Infection

Alicja Chmielewska, Maria Gómez-Herranz, Paulina Gach, Marta Nekulová et autres

TBEV infection may result in encephalitis, chronic illness, or death. TBEV is endemic in northern Asia and Europe; however, due to climate change, new centers of endemicity have arisen. Although effective TBEV vaccines have been approved, vaccination coverage is low, and due …

pl, gb, cz, cn (code pays fourni par la source)

Expansion of a SARS-CoV-2 Delta variant with an 872 nt deletion encompassing ORF7a, ORF7b and ORF8, Poland, July to August 2021

Natalia Mazur-Panasiuk, Łukasz Rąbalski, Tomasz Gromowski, Grzegorz Nowicki et autres

Routine genomic surveillance on samples from COVID-19 patients collected in Poland during summer 2021 revealed the emergence of a SARS-CoV-2 Delta variant with a large 872 nt deletion. This change, confirmed by Sanger and deep sequencing, causes complete loss of ORF7a, ORF7b, …

pl (code pays fourni par la source)