Danielle Graham

Quantitative Systems Pharmacology Model for Therapies Targeting Aβ and Tau Pathologies in Alzheimer’s Disease

Lin Lin, Sarah Minucci, Sarah DiBartolo, Joshuaine Grant et autres

Abstract Background Alzheimer’s disease (AD) is a progressive neurodegenerative disease characterized by the formation of amyloid‐beta (Aβ) plaques and neurofibrillary tangles (NFTs) composed of tau aggregates. Research in animal models has generated hypotheses on the underlying mechanisms of the interaction between Aβ …

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Progranulin Is a Chemoattractant for Microglia and Stimulates Their Endocytic Activity

Fiona Pickford, Jacob Marcus, Luiz Miguel Camargo, Qiurong Xiao et autres

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Intra-arterial histamine increases blood-brain transport in rats

P. M. Gross, Graham M. Teasdale, Danielle Graham, Wilson J. Angerson et autres

The neurotransmitter histamine is located in multiple compartments in the brain and may influence cerebral vessels during some conditions. We made measurements of cerebrovascular transport of labeled sucrose, alpha-aminoisobutyric acid (AIB), and horseradish peroxidase during sustained infusion of histamine into the internal …

Internalization of neuronal plasma membrane ricin receptors into the Golgi apparatus

Nicholas K. Gonatas, Anna Steiber, S.U. Kim, Danielle Graham et autres

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The undifferentiated and extended forms of C1300 murine neuroblastoma. An ultrastructural study and detection of concanavalin A binding sites on the plasma membrane.

Danielle Graham, N K Gonatas, Frixos C. Charalampous

Mouse neuroblastoma cells (clone neuro-2A) in the undifferentiated and "differentiated" form were compared by light and electron microscopy. "Cytodifferentiation" was induced in monolayer cultures by the addition of dibutyryl-cyclic AMP. The pattern of concanavalin A binding sites was studied after coupling with …