Accès ouvert
2024
article
OpenAlex
Lin Lin, Sarah Minucci, Sarah DiBartolo, Joshuaine Grant et autres
Abstract Background Alzheimer’s disease (AD) is a progressive neurodegenerative disease characterized by the formation of amyloid‐beta (Aβ) plaques and neurofibrillary tangles (NFTs) composed of tau aggregates. Research in animal models has generated hypotheses on the underlying mechanisms of the interaction between Aβ …
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Accès ouvert
2024
article
OpenAlex
Sarah Minucci, Scott Gruver, Kalyanasundaram Subramanian, Marissa Renardy
Chimeric antigen receptor T (CAR T) cell therapy has shown remarkable success in treating various leukemias and lymphomas. Cellular kinetic (CK) and pharmacodynamic (PD) behavior of CAR T cell therapy is distinct from other therapies due to its living nature. CAR T …
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Accès ouvert
2024
article
OpenAlex
Quintessa Hay, Christopher Grubb, Sarah Minucci, Michael Valentine et autres
A variety of pulmonary insults can prompt the need for life-saving mechanical ventilation; however, misuse, prolonged use, or an excessive inflammatory response, can result in ventilator-induced lung injury. Past research has observed an increased instance of respiratory distress in older patients and …
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Accès ouvert
2024
article
OpenAlex
Sarah Minucci, Rebecca L. Heise, Angela Reynolds
Macrophages show high plasticity and result in heterogenic subpopulations or polarized states identified by specific cellular markers. These immune cells are typically characterized as pro-inflammatory, or classically activated M1, and anti-inflammatory, or alternatively activated M2. However, a more precise definition places them …
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Accès ouvert
2023
preprint
OpenAlex
Quintessa Hay, Christopher Grubb, Sarah Minucci, Michael Valentine et autres
Abstract A variety of pulmonary insults can result in the necessity for mechanical ventilation, which, when misused, used for prolonged periods of time, or associated with an excessive inflammatory response, can result in ventilator-induced lung injury. Older patients have been observed to …
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Accès ouvert
2022
preprint
OpenAlex
Sarah Minucci, Rebecca L. Heise, Angela Reynolds
Abstract Macrophages show high plasticity and result in heterogenic subpopulations or polarized states identified by specific cellular markers. These immune cells are typically characterized as pro-inflammatory, or classically activated M1, and anti-inflammatory, or alternatively activated M2. However, a more precise definition places …
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Accès ouvert
2021
article
OpenAlex
Sarah Minucci, Rebecca L. Heise, Michael Valentine, Franck J. Kamga Gninzeko et autres
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Accès ouvert
2020
article
OpenAlex
Sarah Minucci, Rebecca L. Heise, Angela Reynolds
Lung inflammation may occur due to viral and bacterial infections, structural damage, or inhalation of dangerous particles. These injuries may be quickly resolved by the immune system, treated effectively through various interventions, become chronic problems, or lead to death. Mathematical modeling has …
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Accès ouvert
2020
preprint
OpenAlex
Sarah Minucci, Rebecca L. Heise, Michael Valentine, Franck J. Kamga Gninzeko et autres
Respiratory infections, such as the novel coronavirus (SARS-COV-2) and other lung injuries, damage the pulmonary epithelium. In the most severe cases this leads to acute respiratory distress syndrome (ARDS). Due to respiratory failure associated with ARDS, the clinical intervention is the use …
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Accès ouvert
2020
conference-paper
OpenAlex
Sarah Minucci, Rebecca L. Heise, Michael Valentine, Franck J. Kamga Gninzeko et autres
2019
conference-paper
OpenAlex
Sarah Minucci
Abstract Respiratory infections, such as the novel coronavirus (SARS-COV-2), and other lung injuries infect and damage the pulmonary epithelium. In the most severe cases this leads to acute respiratory distress syndrome (ARDS). Due to respiratory failure associated with ARDS, the clinical intervention …
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2017
book-chapter
OpenAlex
Stephen J. Merrill, Sarah Minucci
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