Víctor Hugo Aquino

Decoding yellow fever virus immunogenicity: Targeting highly effective epitopes of YFV for next-generation vaccine design

Víctor Hugo Aquino, Maria Leticia Gomez

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Dengue on the rise in Encarnación, Paraguay (2023–2024): an emerging threat to regional transmission dynamics

D P Dressler, Andrea Gómez de la Fuente, Cesar Cantero, Tania Alfonzo et autres

INTRODUCTION: Dengue remains a public health concern in Paraguay. Paraguay´s 2023-2024 epidemic was examined, emphasizing on the Itapua department in the southern region bordering Argentina. METHODOLOGY: This retrospective, cross-sectional observational study analyzed confirmed dengue cases from 17 September 2023, to 4 May …

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Prevalence of CMV glycoprotein B genotypes in newborns with congenital CMV infection in Southern Bahia, Brazil

Lauro Juliano Marin, Felipe Charu Ramos, Pérola Rodrigues dos Santos, Uener Ribeiro dos Santos et autres

Cytomegalovirus (CMV) is a common herpesvirus that causes congenital infections with significant neonatal health risks. This study characterized CMV glycoprotein B (gB) genotypes among 2,595 newborns in Southern Bahia, Brazil. CMV DNA was detected in 1.19% of cases, with gB1, gB2, and …

Congenital CMV infection in a Brazilian neonatal intensive care unit: high prevalence among twin newborns

Lauro Juliano Marin, Pérola Rodrigues dos Santos, Felipe Charu Ramos, Uener Ribeiro dos Santos et autres

BACKGROUND: Cytomegalovirus (CMV) is one of the most important pathogens associated with congenital infection worldwide. Most congenital CMV-infected infants are asymptomatic at birth; however, some can develop delayed sequelae, especially hearing loss. METHODS: This study aimed to investigate the prevalence of congenital …

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Performance evaluation of Biofire Film Array Respiratory Panel 2.1 for SARS-CoV-2 detection in a pediatric hospital setting

Mirta Mesquita, Miria Noemi Zarate, Leonidas Adelaida Rodriguez, Víctor Hugo Aquino

The highly contagious nature of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of Coronavirus Disease 2019 (COVID-19), requires rapid diagnostic tests to prevent the virus from spreading within hospitals and communities. Reverse transcription followed by the polymerase chain …

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Linear epitope mapping in the E and NS1 proteins of dengue and Zika viruses: Prospection of peptides for vaccines and diagnostics

Víctor Hugo Aquino, Marcílio Jorge Fumagalli, Angélica Silva, Bento Vidal de Moura Negrini et autres

The arrival of the Zika virus (ZIKV) in dengue virus (DENV)-endemic areas has posed challenges for both differential diagnosis and vaccine development. Peptides have shown promise in addressing these issues. The aim of this study was to identify the linear epitope profile …

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Latin America in the clutches of an old foe: Dengue

Marcel Alied, Patrícia Takako Endo, Víctor Hugo Aquino, Venkata Vasavi Vadduri et autres

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Screening of febrile patients with suspected malaria from the Brazilian Amazon for virus infection

Mário Luis Garcia de Figueiredo, Evan P. Williams, Colleen B. Jonsson, Mohd Jaseem Khan et autres

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Steroidal saponins from the roots of Solanum sisymbriifolium Lam. (Solanaceae) have inhibitory activity against dengue virus and yellow fever virus

Glauciane Garcia de Figueiredo, Oscar Andrés Del Ángel Coronel, A.C. Trabuco, Diana Bazán et autres

Dengue is the most important arthropod-borne viral disease worldwide. Infection with any of the four dengue virus (DENV) serotypes can be asymptomatic or lead to disease with clinical symptoms ranging from undifferentiated and self-limiting fever to severe dengue disease, which can be …

Linear and Continuous Flavivirus Epitopes From Naturally Infected Humans

Marcílio Jorge Fumagalli, Luiz Tadeu Moraes Figueiredo, Víctor Hugo Aquino

genus. We summarized 153 immunoreactive peptides from the Dengue virus, Zika virus, Japanese encephalitis virus, West Nile virus, and tick-borne encephalitis virus described in studies published from 1989 to 2020. We included peptides from structural (envelope, capsid, and pre-membrane) and nonstructural (Ns1-5) …

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Revisiting the dengue epidemic of 2011 in Paraguay: molecular epidemiology of dengue virus in the Asuncion metropolitan area

Alejandra Rojas, Adriana Moreira Soares, Laura Mendoza, María Eugenia Acosta et autres

BACKGROUND: Dengue is one of the most important re-emerging viral diseases and the most common human arthropod-borne viral infection worldwide. Any of the four Dengue virus serotypes (DENV-1 to 4) can cause asymptomatic infections or clinical manifestations that range in severity from …

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Chikungunya virus entry is strongly inhibited by phospholipase A2 isolated from the venom of Crotalus durissus terrificus

Igor Andrade Santos, Jacqueline Farinha Shimizu, Débora Moraes de Oliveira, Daniel Oliveira Silva Martins et autres

Abstract Chikungunya virus (CHIKV) is the etiologic agent of Chikungunya fever, a globally spreading mosquito-borne disease. There is no approved antiviral or vaccine against CHIKV, highlighting an urgent need for novel therapies. In this context, snake venom proteins have demonstrated antiviral activity …

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