Ishwar N. Kohale

Uncovering the signaling networks of disseminated glioblastoma cells in vivo with INSIGHT

Ryuhjin Ahn, Alicia D. D’Souza, Lü Long, Yufei Cui et autres

Abstract Dysregulation of intracellular signaling networks underpins cancer. However, a systems-level elucidation of how signaling networks within distinct cell subpopulations drive cancer progression in vivo has been unattainable due to technical limitations. We developed INSIGHT (INvestigating SIGnaling network of specific cell subpopulation …

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Uncovering the signaling networks of disseminated glioblastoma cells in vivo with INSIGHT.

Ryuhjin Ahn, Alicia D. D’Souza, Lü Long, Yufei Cui et autres

Dysregulation of intracellular signaling networks underpins cancer. Yet, resolving signaling networks within distinct or rare cell types in cancer in vivo has been unattainable. Here we develop INSIGHT by integrating cell sorting with mass spectrometry to enable quantitative phosphoproteomics and proteomics of …

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Persistent interferon signaling and clonal expansion mark early events in DNA methylation damage-induced liver cancer

Lee J. Pribyl, Jennifer E. Kay, Joshua J. Corrigan, Lindsay B. Volk et autres

Abstract N-Nitrosodimethylamine (NDMA), a probable human carcinogen, induces toxic and mutagenic O 6 -methylguanine lesions that are repaired by the O 6 -methylguanine methyltransferase (MGMT). To elucidate mechanisms of NDMA-induced liver cancer progression, we performed longitudinal analyses of phenomic, transcriptomic, and phosphoproteomic …

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Abstract 7086: Preclinical characterization of a potent and selective Werner helicase (WRN) inhibitor with activity in low-TA repeat microsatellite instability-high (MSI-H) cancers

Pablo E. Hollstein, Daniel Andrew Aiello, Anne Y. Saiki, Keegan S. Cooke et autres

Abstract Werner syndrome helicase (WRN), a member of the RecQ family of DNA helicases, is a synthetic-lethal dependency in DNA mismatch repair-deficient cancers that exhibit high microsatellite instability (MSI-H). Here, we characterize Compound 1, a potent and selective small molecule WRN inhibitor. …

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Patient-specific signaling signatures predict optimal therapeutic combinations for triple negative breast cancer

Heba Alkhatib, Jason E. Conage‐Pough, Sangita Roy Chowdhury, Denen Shian et autres

Triple negative breast cancer (TNBC) is a heterogeneous group of tumors which lack estrogen receptor, progesterone receptor, and HER2 expression. Targeted therapies have limited success in treating TNBC, thus a strategy enabling effective targeted combinations is an unmet need. To tackle these …

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Data from Quantitative Analysis of Tyrosine Phosphorylation from FFPE Tissues Reveals Patient-Specific Signaling Networks

Ishwar N. Kohale, Danielle M. Burgenske, Ann C. Mladek, Katrina K. Bakken et autres

Abstract Human tissue samples commonly preserved as formalin-fixed paraffin-embedded (FFPE) tissues after diagnostic or surgical procedures in the clinic represent an invaluable source of clinical specimens for in-depth characterization of signaling networks to assess therapeutic options. Tyrosine phosphorylation (pTyr) plays a fundamental …

Supplementary Data from Quantitative Analysis of Tyrosine Phosphorylation from FFPE Tissues Reveals Patient-Specific Signaling Networks

Ishwar N. Kohale, Danielle M. Burgenske, Ann C. Mladek, Katrina K. Bakken et autres

Supplementary Data from Quantitative Analysis of Tyrosine Phosphorylation from FFPE Tissues Reveals Patient-Specific Signaling Networks

Supplementary Data from Quantitative Analysis of Tyrosine Phosphorylation from FFPE Tissues Reveals Patient-Specific Signaling Networks

Ishwar N. Kohale, Danielle M. Burgenske, Ann C. Mladek, Katrina K. Bakken et autres

Supplementary Data from Quantitative Analysis of Tyrosine Phosphorylation from FFPE Tissues Reveals Patient-Specific Signaling Networks

Supplementary Data from Quantitative Analysis of Tyrosine Phosphorylation from FFPE Tissues Reveals Patient-Specific Signaling Networks

Ishwar N. Kohale, Danielle M. Burgenske, Ann C. Mladek, Katrina K. Bakken et autres

Supplementary Data from Quantitative Analysis of Tyrosine Phosphorylation from FFPE Tissues Reveals Patient-Specific Signaling Networks

us (code pays fourni par la source)

Supplementary Data from Quantitative Analysis of Tyrosine Phosphorylation from FFPE Tissues Reveals Patient-Specific Signaling Networks

Ishwar N. Kohale, Danielle M. Burgenske, Ann C. Mladek, Katrina K. Bakken et autres

Supplementary Data from Quantitative Analysis of Tyrosine Phosphorylation from FFPE Tissues Reveals Patient-Specific Signaling Networks

us (code pays fourni par la source)

Supplementary Data from Quantitative Analysis of Tyrosine Phosphorylation from FFPE Tissues Reveals Patient-Specific Signaling Networks

Ishwar N. Kohale, Danielle M. Burgenske, Ann C. Mladek, Katrina K. Bakken et autres

Supplementary Data from Quantitative Analysis of Tyrosine Phosphorylation from FFPE Tissues Reveals Patient-Specific Signaling Networks

Supplementary Data from Quantitative Analysis of Tyrosine Phosphorylation from FFPE Tissues Reveals Patient-Specific Signaling Networks

Ishwar N. Kohale, Danielle M. Burgenske, Ann C. Mladek, Katrina K. Bakken et autres

Supplementary Data from Quantitative Analysis of Tyrosine Phosphorylation from FFPE Tissues Reveals Patient-Specific Signaling Networks