Efrat Ben‐Shalom

Linear growth in pediatric kidney transplant recipients

Hadeel Abu-Ghanam, Shimrit Tzvi-Behr, Jenny Weinbrand-Goichberg, Floris Levy‐Khademi et autres

BACKGROUND: Growth impairment is a major concern in children with chronic kidney disease (CKD). Over the past two decades, recombinant human growth hormone (rhGH) has significantly improved linear growth in this population. Current recommendations support rhGH treatment in children with CKD who …

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#2388 Long-term efficacy and safety in the 60-month, Phase 3 ILLUMINATE-B trial of lumasiran in infants and young children with primary hyperoxaluria type 1

Yaacov Frishberg, Wesley Nathan Hayes, Efrat Ben‐Shalom, Hadas Shasha‐Lavsky et autres

Abstract Background and Aims Primary hyperoxaluria type 1 (PH1) is a genetic disorder resulting in excess hepatic oxalate production, potentially leading to urolithiasis, nephrocalcinosis (NC), and ultimately, chronic kidney disease, kidney failure, and systemic oxalosis. Lumasiran, the first liver-directed RNA interference therapeutic …

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Final 60-Month Efficacy, Safety, and Kidney Stone Outcomes of a Phase 3 Trial of Lumasiran for Primary Hyperoxaluria Type 1 in Infants and Young Children

David J. Sas, Mini Michael, Yaacov Frishberg, Wesley Nathan Hayes et autres

Background: Primary hyperoxaluria type 1 (PH1) is a genetic disease of oxalate overproduction leading to urolithiasis, nephrocalcinosis (NC), and systemic oxalosis. Lumasiran is the first liver-directed RNA interference therapeutic for PH1 administered to infants and children age ≤6 years. We present final …

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Comparison of Patients with Primary Hyperoxaluria 1 and Late-Stage CKD from the BONAPH1DE Registry and ILLUMINATE-C Lumasiran Trial

John Charles Lieske, Michelle A. Baum, Efrat Ben‐Shalom, Vladimir Belostotsky et autres

Background: Patients (pts) with primary hyperoxaluria type 1 (PH1) and late-stage chronic kidney disease (CKD) from the real-world observational BONAPH1DE study (BPH1; NCT04982393) and Phase 3 ILLUMINATE-C trial (ILLUM-C; NCT04152200) were reviewed to assess if pt characteristics and outcomes in these real-world …

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Emphysematous pyelonephritis and infection-related calculi

Shimrit Tzvi-Behr, Yaacov Frishberg, Ruth Cytter-Kuint, Boris Chertin et autres

Emphysematous pyelonephritis (EPN) is a critical and life-threatening necrotizing urinary tract infection, marked by gas formation within the renal parenchyma, collecting system or peri-nephric tissue and is extremely rare in children. Proteinaceous calculi are a rare type of kidney stones, reported in …

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The incidence of acute kidney injury in very-low-birth-weight infants treated early with caffeine

Shimrit Tzvi-Behr, Noam Schlesinger, Efrat Ben‐Shalom, Yaacov Frishberg et autres

BACKGROUND: Acute kidney injury (AKI) in neonates is associated with increased morbidity and mortality, longer hospitalization, and a higher risk for future kidney damage. Caffeine treatment has reportedly been associated with a decreased AKI occurrence. However, previous studies lack uniformity regarding dosage …

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Low incidence of acute kidney injury in very low birth weight infants with early caffeine treatment - a single center study

Noam Schlesinger, Shimrit Tzvi-Behr, Efrat Ben‐Shalom, Yaacov Frishberg et autres

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Post-contrast acute kidney injury in the super-elder patients: a CT-scan perspective

Yedidah Fraenkel, Naama Bogot, Ruth Cytter Kuint, Efrat Ben‐Shalom et autres

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Associations Between Prematurity, Birthweight, and Adolescence Blood Pressure in a Nationwide Cohort

Shimrit Tzvi-Behr, Lucy Balagour Greenstein, Efrat Ben‐Shalom, Yaacov Frishberg

Introduction: Prematurity is associated with incomplete nephrogenesis and an increased incidence of acute kidney injury, that may increase the risk of future kidney disease, including hypertension, proteinuria and reduced glomerular filtration rate. The aim of this study was to evaluate the risk …

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The incidence of Acute Kidney Injury in preterm infants treated with early high dose caffeine

Yair M. Kasirer, Noam Schlesinger, Shimrit Tzvi-Behr, Yaacov Frishberg et autres

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Acute glomerulonephritis with concurrent suspected bacterial pneumonia – is it the tip of the iceberg?

Shimrit Tzvi-Behr, Yaacov Frishberg, Orli Megged, Jenny Weinbrand-Goichberg et autres

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Prematurity and Low Birth Weight Associate with Adolescent Hypertension in a Large Nationwide Cohort

Shimrit Tzvi-Behr, Efrat Ben‐Shalom, Yaacov Frishberg

Background: prematurity is a global burden occuring in ˜ 11% of total deliveries. Chronic kidney disease (CKD), due to incomplete nephrogenesis and acute kidney injury episodes, can be a long term complication of prematurity. The aim of this study is to explore …

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