Maria‐Elena Torres‐Padilla

ERH elicits cell lineage restriction in mammalian preimplantation development and differentiation from pluripotency via H3K9me3-heterochromatin

Andrew Katznelson, Blake Hernandez, Kylea Tapia, Holly Fahning et autres

Enhancer of Rudimentary Homolog (ERH) is an evolutionarily conserved protein originally characterized as promoting fission yeast heterochromatin and recently shown to maintain H3K9me3 heterochromatin in human fibroblasts. Here, we find that ERH depletion in fibroblasts reverts the somatic cell H3K9me3 landscape of …

us, de (code pays fourni par la source)

Addendum: Retinoic acid signaling is critical during the totipotency window in early mammalian development

Ane Iturbide, Mayra L. Ruiz Tejada Segura, Camille Noll, Kenji Schorpp et autres

de, gb (code pays fourni par la source)

Stem cells as role models for reprogramming and repair

Magdalena Götz, Maria‐Elena Torres‐Padilla

Stem cells are a promising source for cellular therapies across many diseases and tissues. Their inherent ability to differentiate into other cell types has been the focus of investigation over decades. This ability is currently being exploited for therapies using strategies to …

de (code pays fourni par la source)

Abstract SY23-01: Diffuse midline gliomas: From cell cycle to therapeutic opportunities

Anastasia E. Hains, Joana Graca Marques, Kashish Chetal, Tsunetoshi Nakatani et autres

Abstract The fatal Diffuse Midline Gliomas (DMG) are characterized by an undruggable H3K27M mutation in H3.1 or H3.3. K27M impairs normal development by stalling of differentiation. As replication timing influences gene expression, cell fate, and cellular response to therapeutics, we undertook a …

us, de (code pays fourni par la source)

The establishment of nuclear organization in mouse embryos is orchestrated by multiple epigenetic pathways

Mrinmoy Pal, Tamás Schauer, Adam Burton, Tsunetoshi Nakatani et autres

The folding of the genome in the 3D nuclear space is fundamental for regulating all DNA-related processes. The association of the genome with the nuclear lamina into lamina-associated domains (LADs) represents the earliest feature of nuclear organization during development. Here, we performed …

de, es (code pays fourni par la source)

RIF1 controls replication timing in early mouse embryos independently of lamina-associated nuclear organization

Tsunetoshi Nakatani, Tamás Schauer, Mrinmoy Pal, Andreas W. Ettinger et autres

Cells must duplicate their genome before they divide to ensure equal transmission of genetic information. The genome is replicated with a defined temporal order, replication timing (RT), which is cell-type specific and linked to 3D-genome organization. During mammalian development, RT is initially …

de, us (code pays fourni par la source)

Epigenome dynamics in early mammalian embryogenesis

Adam Burton, Maria‐Elena Torres‐Padilla

de (code pays fourni par la source)

The transcription factor SRF regulates MERVL retrotransposons and gene expression during zygotic genome activation

Clara Hermant, Carlos Michel Mourra-Díaz, Marlies E. Oomen, Luis Altamirano‐Pacheco et autres

The regulatory circuitry of cell-specific transcriptional programs is thought to be influenced by transposable elements (TEs), whereby TEs serve as raw material for the diversification and genome-wide distribution of genetic elements that containcis-regulatory activity. However, the transcriptional activators of TEs in relevant …

de (code pays fourni par la source)

An atlas of transcription initiation reveals regulatory principles of gene and transposable element expression in early mammalian development

Marlies E. Oomen, Diego Rodriguez‐Terrones, Mayuko Kurome, Valeri Zakhartchenko et autres

Transcriptional activation of the embryonic genome (EGA) is a major developmental landmark enabling the embryo to become independent from maternal control. The magnitude and control of transcriptional reprogramming during this event across mammals remains poorly understood. Here, we developed Smart-seq+5' for high …

de, fr, sg (code pays fourni par la source)

Multi-omics approaches reveal that diffuse midline gliomas present altered DNA replication and are susceptible to replication stress therapy

Anastasia E. Hains, Kashish Chetal, Tsunetoshi Nakatani, Joana Graca Marques et autres

BACKGROUND: The fatal diffuse midline gliomas (DMG) are characterized by an undruggable H3K27M mutation in H3.1 or H3.3. K27M impairs normal development by stalling differentiation. The identification of targetable pathways remains very poorly explored. Toward this goal, we undertake a multi-omics approach …

us, de (code pays fourni par la source)

Understanding how cells and organisms keep time during development

Miki Ebisuya, Teresa Rayón, Margarete Díaz-Cuadros, Kevin J. Chalut et autres

Mapping putative enhancers in mouse oocytes and early embryos reveals TCF3/12 as key folliculogenesis regulators

Bofeng Liu, Yuanlin He, Xiaotong Wu, Zili Lin et autres

cn, de, us (code pays fourni par la source)