Markku Heikinheimo

Interplay between fibroblast growth factor 9 (FGF9) and CD44 underlies 46,XY disorders of sex development in Kruppel‐like factor 1 (KLF‐1)‐E325K‐associated congenital dyserythropoietic anaemia (CDA‐IV)

Yaddanapudi Ravindranath, Douglas B. Craig, Prahlad Parajuli, Shruti Bagla et autres

A heterozygous Kruppel-like factor 1 (KLF1) E325K mutation causes a severe form of congenital dyserythropoietic anaemia (CDA), designated CDA-IV (Online Mendelian Inheritence in Man, OMIM 613673), a rare disease with only 15 cases known. In addition to haemolytic anaemia, manifest often at …

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Macrophage Polarization and Spatial Architecture Characterize the Tumor Immune Microenvironment and Prognosis in Hepatoblastoma

Ville Väyrynen, Katja Eloranta, Markus Talka, Antti Tuhkala et autres

Hepatoblastoma, the most common primary pediatric liver malignancy, exhibits resistance to contemporary treatments in a subset of patients. Understanding the tumor immune microenvironment is essential for the development of novel immuno-oncological therapies. Herein, the microenvironment of hepatoblastoma was characterized by mapping the …

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Accumulation of altered serum bile acids predicts liver injury after portoenterostomy in biliary atresia

Iiris Nyholm, Maria Hukkinen, Jouko Lohi, Nelli Sjöblom et autres

BACKGROUND & AIMS: Little is known about the mechanism of liver injury mediated by bile acids following Kasai portoenterostomy (KPE) for biliary atresia (BA). We sought to quantify individual serum bile acids, 7-alpha-hydroxy-4-cholesten-3-one (C4), and fibroblast growth factor 19 (FGF19) after KPE …

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161 (PB149): Immune landscape and CLEVER-1 expression in hepatoblastoma

Ville Väyrynen, Kari Eloranta, Marjut Pihlajoki, Jouni J. Lohi et autres

Konsensusehdotukset dosentin arvon myöntämiseen liittyvistä käytänteistä ja näkökulmista

Anna Axelin, Markku Heikinheimo, Sami Heistaro, Kai Kaarniranta et autres

Konsensusehdotukset dosentin arvon myöntämiseen liittyvistä käytänteistä ja näkökulmista D osentin arvon myöntämisen käytänteissä on eroja maamme viiden lääketieteellistä koulutusta antavan yliopiston välillä.Lääketieteen alalla harmonisoinnille on monia tarpeita erityisesti yhdenvertaisuuden näkökulmasta: dosentin arvo on muun muassa eduksi erikoistumiskoulutukseen haettaessa, ja sitä vaaditaan myös …

Deep learning quantification reveals a fundamental prognostic role for ductular reaction in biliary atresia

Iiris Nyholm, Nelli Sjöblom, Marjut Pihlajoki, Maria Hukkinen et autres

BACKGROUND: We aimed to quantify ductular reaction (DR) in biliary atresia using a neural network in relation to underlying pathophysiology and prognosis. METHODS: Image-processing neural network model was applied to 259 cytokeratin-7-stained native liver biopsies of patients with biliary atresia and 43 …

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171P Immune landscape and CLEVER-1 expression in hepatoblastoma

Ville Väyrynen, Kari Eloranta, Marjut Pihlajoki, Jouni J. Lohi et autres

Hepatoblastoma (HB) is the most common primary liver malignancy among infants and young children. HBs are regarded as embryonal tumors arising from hepatic progenitor cells. Current treatment modalities for HB produce unsatisfactory results (20-30% respond poorly to interventions). To decrease adverse effects …

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Biology of childhood hepatoblastoma and the search for novel treatments

Marjut Pihlajoki, Katja Eloranta, Ruth Nousiainen, Ville Väyrynen et autres

Our research laboratory has a longstanding interest in developmental disorders and embryonic tumors, and recent efforts have focused on the pathogenesis of pediatric liver tumors. This review focuses on hepatoblastoma (HB), the most common pediatric liver malignancy. Despite advances in treatment, patients …

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Particle discrimination in a NaI crystal using the COSINUS remote TES design

COSINUS Collaboration, G. Angloher, Ioan Dafinei, N. Di Marco et autres

The COSINUS direct dark matter experiment situated at Laboratori Nazionali del Gran Sasso in Italy is set to investigate the nature of the annually modulating signal detected by the DAMA/LIBRA experiment. COSINUS has already demonstrated that sodium iodide crystals can be operated …

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Bacterial translocation markers and toll‐like receptors in biliary atresia following successful portoenterostomy

Nimish Godbole, Antti Kyrönlahti, Maria Hukkinen, Marjut Pihlajoki et autres

AIM: The gut-liver axis may contribute to pathophysiology of cholestatic liver disorders like biliary atresia (BA) by bacterial translocation (BT). Toll-like receptors (TLR) are pattern recognition receptors known to activate innate immunity and secretion of inflammatory cytokines. Herein, we examined BT-associated biomarkers …

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UBE2C expression is elevated in hepatoblastoma and correlates with inferior patient survival

Ruth Nousiainen, Katja Eloranta, Noora Isoaho, Stefano Cairo et autres

Hepatoblastoma (HB) is the most common malignant liver tumor among children. To gain insight into the pathobiology of HB, we performed RNA sequence analysis on 5 patient-derived xenograft lines (HB-243, HB-279, HB-282, HB-284, HB-295) and 1 immortalized cell line (HUH6). Using cultured …

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Deep learning quantification reveals fundamental prognostic role for ductular reaction in biliary atresia

Iiris Nyholm, Nelli Sjöblom, Maria Hukkinen, Marjut Pihlajoki et autres