Maarten Coemans

403.1: Subthreshold inflammation matters: A continuum model of TCMR risk.

Karolien Wellekens, Priyanka Koshy, Maarten Coemans, Arthur Vranken et autres

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Non-HLA antibodies worsen the histological phenotype and prognosis of antibody mediated rejection in kidney allografts

Emilie Lebraud, Olivier Aubert, Laïla Aouni, Virginia Garcia et autres

INTRODUCTION: Antibody-mediated rejection (AMR) remains a leading cause of kidney allograft failure, with both HLA and non-HLA antibodies implicated in its pathogenesis. The contribution of non-HLA antibodies (non-HLA Abs) to microvascular inflammation (MVI) and graft outcome, particularly in cases lacking donor-specific anti-HLA …

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A discrete time simulation model for kidney allocation in Germany

Nassim Kakavand, Maarten Coemans, Hans de Ferrante, Benedikt Kolbrink et autres

The ongoing shortage of kidney donations increases pressure to optimize utility and equity in kidney allocation; simulation models allow evaluation of policy changes before implementation. Using data from the German national transplant registry (19,517 kidney transplants), human leukocyte antigen (HLA) information from …

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Clinical Relevance of Donor-Derived Cell-Free DNA in Monitoring Kidney Transplant Rejection

Angelica Pagliazzi, Karolien Wellekens, Henriëtte de Loor, Priyanka Koshy et autres

KEY POINTS: Donor-derived cell-free DNA showed strong discriminative ability for rejection after kidney transplantation. Clinical interpretability was improved by calculating donor-derived cell-free DNA result-specific likelihood ratio and corresponding post-test rejection risk. We showed that donor-derived cell-free DNA testing could help reduce unnecessary …

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Cytomegalovirus Infection Determines Microvascular Inflammation Risk beyond Alloimmunity in Kidney Transplantation

Maarten Naesens, Thomas Vanhoutte, Matthias Diebold, Karolien Wellekens et autres

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Continuous Transcriptomic Indices for Assessing the Spectrum of Kidney Transplant Rejection: International Derivation and Validation Study

Maarten Naesens, Karolien Wellekens, Thibaut Vaulet, Hao zhang et autres

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Repeated histological diagnoses and kidney graft failure: an observational cohort study

Arthur Vranken, Maarten Coemans, Bemelman Fj, Bertrand Chauveau et autres

Abstract Background The effects of Banff histological diagnoses on kidney transplant outcome have been well characterized. However, repeated observation of such histological injury across multiple biopsies in kidney transplant recipients remains insufficiently explored. Methods In an observational cohort (N=1819 transplantations with 5736 …

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Non-HLA antibodies worsen the histological phenotype and prognosis of antibody mediated rejection in kidney allografts

Emilie Lebraud, Olivier Aubert, Laila Aouni, Virginia Garcia et autres

ABSTRACT Introduction Antibody-mediated rejection (AMR) remains a leading cause of kidney allograft failure, with both HLA and non-HLA antibodies implicated in its pathogenesis. The contribution of non-HLA antibodies (non-HLA Abs) to microvascular inflammation (MVI) and graft outcome, particularly in cases lacking donor-specific …

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Continuous indices to assess the phenotypic spectrum of kidney transplant rejection

Thibaut Vaulet, Priyanka Koshy, Karolien Wellekens, Olivier Aubert et autres

The Banff classification for kidney transplant pathology dichotomizes the rejection continuum into distinct diagnostic categories, introducing artificial cutoff points and threshold effects. To better reflect the underlying disease spectrum, in this cohort study of 19,500 biopsies from 8873 patients across 10 centers …

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Socioeconomic Deprivation and Kidney Transplant Outcomes

Lukas Ponette, Karolien Wellekens, Priyanka Koshy, Arthur Vranken et autres

Introduction: Socioeconomic deprivation adversely affects health outcomes, including those after kidney transplantation.Retrospective studies, including 92,844 patients in the US and 19,103 and 621 in two UK cohorts, reported higher mortality and graft rejection among deprived individuals.The persistence of these disparities in the …

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The Enemies of Reliable and Useful Clinical Prediction Models: A Review of Statistical and Scientific Challenges

Ben Van Calster, Maarten van Smeden, Wouter van Amsterdam, Maarten Coemans et autres

The current status of applied clinical prediction modeling is poor. Many models are developed with suboptimal methods and are not evaluated, and hence have little impact on clinical care. We review 12 challenges—provocatively labeled enemies—that jeopardize the creation of prediction models that …

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Intimal Arteritis ('v') in Kidney Transplant Rejection: Multicenter Clinical and Molecular Evidence Challenging the Banff 2022 Classification

Karolien Wellekens, Maarten Coemans, Priyanka Koshy, Thibaut Vaulet et autres

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