Carmen Silvia de Campos Almeida Vieira

Efficacy of chronic 5-HT 1A receptor agonism by NLX-112 in a mouse model of Spinocerebellar Ataxia type 3

Bruna Ferreira-Lomba, Sara R. Guerreiro, Sara Duarte‐Silva, Daniela Cunha‐Garcia et autres

Abstract Background Spinocerebellar ataxia type 3 (SCA3) is an autosomal dominant neurodegenerative disorder caused by an elongated polyglutamine (polyQ) sequence in the ataxin-3 protein. This expansion triggers neuropathological events, leading to progressive motor disturbances. Currently, no approved therapy exists for this debilitating …

pt, us (code pays fourni par la source)

Dissection of Neurochemical Pathways Across Complexity and Scale

Alice Abbondanza, Nawon Kim, Ricardo A. S. Lima‐Filho, Azin Amin et autres

The field of Neurochemistry spent decades trying to understand how the brain works, from nano to macroscale and across diverse species. Technological advancements over the years allowed researchers to better visualize and understand the cellular processes underpinning central nervous system (CNS) function. …

fr, cz, gb, br, au, it, Rwanda, pt, de, Nigéria, Botswana, cl, us, Afrique du Sud, th, ar, ie, pl, ca, ee (code pays fourni par la source)

Learning the Biochemical Basis of Axonal Guidance: Using Caenorhabditis elegans as a Model

Andreia Teixeira‐Castro, João Carlos Sousa, Carmen Silvia de Campos Almeida Vieira, Joana Pereira‐Sousa et autres

Aim: Experimental models are a powerful aid in visualizing molecular phenomena. This work reports how the worm Caenorhabditis elegans (C. elegans) can be effectively explored for students to learn how molecular cues dramatically condition axonal guidance and define nervous system structure and …

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Aripiprazole Offsets Mutant ATXN3-Induced Motor Dysfunction by Targeting Dopamine D2 and Serotonin 1A and 2A Receptors in C. elegans

Ana Jalles, Carmen Silvia de Campos Almeida Vieira, Joana Pereira‐Sousa, Daniela Vilasboas‐Campos et autres

The atypical antipsychotic aripiprazole is a Food and Drug Administration-approved drug for the treatment of psychotic, mood, and other psychiatric disorders. Previous drug discovery efforts pinpointed aripiprazole as an effective suppressor of Machado–Joseph disease (MJD) pathogenesis, as its administration resulted in a …

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WDR60-mediated dynein-2 loading into cilia powers retrograde IFT and transition zone crossing

Ana R. G. De-Castro, Diogo R. M. Rodrigues, Maria J. G. De-Castro, Neide Vieira et autres

The dynein-2 motor complex drives retrograde intraflagellar transport (IFT), playing a pivotal role in the assembly and functions of cilia. However, the mechanisms that regulate dynein-2 motility remain poorly understood. Here, we identify the Caenorhabditis elegans WDR60 homologue, WDR-60, and dissect the …

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WDR60-mediated dynein-2 loading into cilia powers retrograde IFT and transition zone crossing

Ana R. G. De-Castro, Diogo R. M. Rodrigues, Maria J. G. De-Castro, Neide Vieira et autres

ABSTRACT The dynein-2 motor complex drives retrograde intraflagellar transport (IFT), playing a pivotal role in the assembly and functions of cilia. However, the mechanisms that regulate dynein-2 motility remain poorly understood. Here, we identify the Caenorhabditis elegans WDR60 homolog (WDR-60) and dissect …

pt (code pays fourni par la source)

Expression of an alternatively spliced variant of SORL1 in neuronal dendrites is decreased in patients with Alzheimer’s disease

Giulia Monti, Mads Kjølby, Anne Mette G. Jensen, Mariet Allen et autres

SORL1 is strongly associated with both sporadic and familial forms of Alzheimer's disease (AD), but a lack of information about alternatively spliced transcripts currently limits our understanding of the role of SORL1 in AD. Here, we describe a SORL1 transcript (SORL1-38b) characterized …

dk, us, de (code pays fourni par la source)

Hanseníase e qualidade de vida após alta medicamentosa

Carmen Silvia de Campos Almeida Vieira

A imagem corporal nas ações educativas em autocuidado para pessoas que tiveram hanseníase

Talitha Vieira Gonçalves Batista, Carmen Silvia de Campos Almeida Vieira, María Paula

Os comprometimentos físicos ocasionados pela hanseníase são pactuados nas ações do Plano Nacional de Controle da Hanseníase e são considerados um grave problema de saúde pública. Como forma de prevenir o avanço de incapacidades, o Ministério da Saúde propõe ações educativas em …

br, pt (code pays fourni par la source)

Body image in educational actions in self-care for people who had leprosy

Carmen Silvia de Campos Almeida Vieira

Resumo: Os comprometimentos físicos ocasionados pela hanseníase são pactuados nas ações do Plano Nacional de Controle da Hanseníase e são considerados um grave problema de saúde pública. Como forma de prevenir o avanço de incapacidades, o Ministério da Saúde propõe ações educativas …

Avaliação e controle de contatos faltosos de doentes com hanseníase

Carmen Silvia de Campos Almeida Vieira, Marina Teixeira Soares, Cláudia Tatiana Siqueira Xavier Ribeiro, Letícia Faroni Guimarães da Silva

Descriptive study, with qualitative variables, carried on in the Ambulatory of Specialties Region of Taubaté, in order to evaluate the missing contacts of leprosy patients. Thirty-six records of new cases were analyzed, from January 2003 to July 2004. Ninety-two contacts were identified, …

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Avaliação e controle de contatos faltosos de doentes com hanseníase Evaluación y control de contactos faltantes de enfermos con lepra Evaluation and control of missing contacts of leprosy patients

Carmen Silvia de Campos Almeida Vieira, Marina Teixeira Soares, Cláudia Tatiana Siqueira Xavier Ribeiro, Letícia Faroni Guimarães da Silva

Estudo descritivo, com variáveis qualitativas, realizado no Ambulatório Regional de Especialidades de Taubaté, com objetivo de resgatar e avaliar contatos faltosos de doentes de hanseníase. Analisou-se 36 prontuários de casos novos, no período de janeiro de 2003 a julho de 2004. Identificou-se …