Azin Amin

Dissection of Neurochemical Pathways Across Complexity and Scale

Alice Abbondanza, Nawon Kim, Ricardo A. S. Lima‐Filho, Azin Amin et autres

The field of Neurochemistry spent decades trying to understand how the brain works, from nano to macroscale and across diverse species. Technological advancements over the years allowed researchers to better visualize and understand the cellular processes underpinning central nervous system (CNS) function. …

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Systemic administration of a novel Beclin 1-derived peptide significantly upregulates autophagy in the spinal motor neurons of autophagy reporter mice

Azin Amin, Nirma D. Perera, Doris Tomas, Brittany Cuic et autres

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Efficient systemic CNS delivery of a therapeutic antisense oligonucleotide with a blood-brain barrier-penetrating ApoE-derived peptide

Yuan Qi Yeoh, Azin Amin, Brittany Cuic, Doris Tomas et autres

Antisense oligonucleotide (ASO) has emerged as a promising therapeutic approach for treating central nervous system (CNS) disorders by modulating gene expression with high selectivity and specificity. However, the poor permeability of ASO across the blood-brain barrier (BBB) diminishes its therapeutic success. Here, …

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Autophagy-inducing peptides as a therapy for Amyotrophic lateral sclerosis

Azin Amin

© 2022 Azin Amin

Modular Synthesis of Trifunctional Peptide-oligonucleotide Conjugates via Native Chemical Ligation

Mohadeseh Dastpeyman, John A. Karas, Azin Amin, Bradley J. Turner et autres

Cell penetrating peptides (CPPs) are being increasingly used as efficient vectors for intracellular delivery of biologically active agents, such as therapeutic antisense oligonucleotides (ASOs). Unfortunately, ASOs have poor cell membrane permeability. The conjugation of ASOs to CPPs have been shown to significantly …

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Endosomal escape cell-penetrating peptides significantly enhance pharmacological effectiveness and CNS activity of systemically administered antisense oligonucleotides

Mohadeseh Dastpeyman, Ramin Sharifi, Azin Amin, John A. Karas et autres

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Amyotrophic Lateral Sclerosis and Autophagy: Dysfunction and Therapeutic Targeting

Azin Amin, Nirma D. Perera, Philip M. Beart, Bradley J. Turner et autres

Over the past 20 years, there has been a drastically increased understanding of the genetic basis of Amyotrophic Lateral Sclerosis. Despite the identification of more than 40 different ALS-causing mutations, the accumulation of neurotoxic misfolded proteins, inclusions, and aggregates within motor neurons …

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Why BDA Student membership works for you

Azin Amin

Correlation of the Ratio of Upper Third to Lower Third Circumferences of the Chest with Obstructive Pattern in Spirometry.

Ali Alavi Foumani, Azin Amin, Azita Tangestani Nejad, Ehsan Kazemnejad et autres

BACKGROUND: Obstructive Lung Diseases (OLDs), could lead to progressive hyperinflation of the lungs that cause increased work of breathing, impaired gas exchanges and functional limitations in patients. In this study, thoracic circumference of patients in upper and lower third were measured directly …

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