Chun‐Yuan Chen

Retraction Note: Aged bone matrix-derived extracellular vesicles as a messenger for calcification paradox

Zhen‐Xing Wang, Zhong‐Wei Luo, Fu‐Xing‐Zi Li, Jia Cao et autres

The Authors have retracted this Article following the identification of multiple irregularities in the figures and data, including but not limited to, partial duplication of the field of view between Figs. 3j and 7f duplicated quantitative values in several histology-related quantitative panels …

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Magnetic field-controlled nanozymes effectively overcome therapeutic limitations in tumor ferroptosis therapy

Xin‐Yue Hu, Xiao-Yan Tang, Cong Liu, Xiaoxiao Gong et autres

Iron oxide nanozymes with intrinsic peroxidase-like activity and excellent biosafety are considered ideal agents for inducing tumor ferroptosis. However, their practical catalytic efficiency is often constrained by an inherent delocalized electronic structure and the restrictive tumor antioxidant microenvironment. Herein, we report a …

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Amuc_1473 Links Gut Microbes to Skeletal Homeostasis and Counteracts Multifactorial Osteoporosis

Shan‐Shan Rao, Hai‐Jin Zeng, Zun Wang, Chun‐Gu Hong et autres

Emerging evidence suggests that gut microbiota-derived signals can influence distant organs including the skeleton, yet the key microbial effectors remain elusive. Here, we identify Amuc_1473, a previously uncharacterized protein enriched in extracellular vesicles (EVs) from the commensal bacterium Akkermansia muciniphila (Akk), as …

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Local delivery of OSK factors enables partial cellular reprogramming to mitigate osteoarthritis and cartilage fibrosis

Yi-Wei Liu, Jingtao Zou, Jiang-Shan Gong, Ling Jin et autres

Osteoarthritis (OA) is a prevalent joint disease with a complex etiology, involving epigenetic alterations. Recent studies have suggested the potential of Oct4, Sox2 and Klf4 (OSK) in rejuvenating adult cells and facilitating tissue repair, but their specific role in OA pathophysiology and …

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Exploring the role of intelectin-1 in modulating asthma through the gut–bone–lung axis

Shiyue He, Xinyue Hu, Xiaoxiao Gong, Qiyun Cheng et autres

Background The development of extra-intestinal diseases is often accompanied by disruptions in intestinal microbiota and its metabolites, yet the mechanistic link between the gut microbiota and asthma remains unclear. We investigated whether intelectin-1 (ITLN1) mitigates allergic asthma through the gut‒bone‒lung axis as …

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Air-coupled piezoelectric micromachined ultrasonic transducer array based on low-cost and large remnant polarization PZT thin film

Jia-Ling Lin, Ya‐Han Liu, Chien‐Lun Kao, Shaowei Wu et autres

Due to the development of semiconductor technology, control and driving circuits for large phased arrays have become cheaper and more compact, enabling air-coupled ultrasonic transducer arrays to be applied in areas such as ultrasonic haptic feedback and acoustic levitation. However, current air-coupled …

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Camouflage-aware low-light enhancement and cross-attentional Mamba fusion for RGB-P camouflaged object detection

Weiyun Liang, Chun‐Yuan Chen, Jing Xu, Bin Wang et autres

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First-in-Human, Open-Label, Within-Patient Controlled Study to Evaluate an Extensively Humanized Porcine Donor

Hui Xie, Lijin Zou, Hao Yin, Zhen‐Xing Wang et autres

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Attribute reduction based on classes in incomplete ordered decision systems

Chun‐Yuan Chen, Feng Yin, Lixia Wu, Jianfeng Hu

Dominance-based rough set approach (DRSA) has attracted much attention in multi-criteria decision-making problems for data with preference-ordered relations since its inception. However, in the real world, there is often the challenge of incomplete information. This paper addresses approaches to attribute reduction in …

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Governable AI: Provable Safety Under Extreme Threat Models

Donglin Wang, Wei Yan Liang, Chun‐Yuan Chen, Jing Xu et autres

As AI rapidly advances, the security risks posed by AI are becoming increasingly severe, especially in critical scenarios, including those posing existential risks. If AI becomes uncontrollable, manipulated, or actively evades safety mechanisms, it could trigger systemic disasters. Existing AI safety approaches-such …

Enhanced Skin Wound Healing Through Chemically Modified Messenger RNA Encoding Epidermal Growth Factor ( EGF )

Haiyang Hu, Qianglong Sheng, Fan Yang, Xinyi Wu et autres

Efficient wound healing remains a formidable medical challenge in clinical practice, due to the prevalence of skin defects arising from diverse etiological factors. It is indisputable that epidermal growth factor (EGF) plays a pivotal role in wound repair. However, its clinical application …

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Metformin ameliorates osteoporosis by enhancing bone angiogenesis via the YAP1/TAZ-HIF1α axis

Hao Yin, Zhe Ruan, Tengfei Wan, Zhi-Rou Lin et autres

BACKGROUND: ) as a specialized subset of bone blood vessels that positively regulate bone formation. This study aims to investigate the effects of metformin on bone mass, strength, and angiogenesis in osteoporotic mice, and to elucidate the underlying molecular mechanisms, particularly focusing …

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