Xin‐Yue Hu

Magnetic field-controlled nanozymes effectively overcome therapeutic limitations in tumor ferroptosis therapy

Xin‐Yue Hu, Xiao-Yan Tang, Cong Liu, Xiaoxiao Gong et autres

Iron oxide nanozymes with intrinsic peroxidase-like activity and excellent biosafety are considered ideal agents for inducing tumor ferroptosis. However, their practical catalytic efficiency is often constrained by an inherent delocalized electronic structure and the restrictive tumor antioxidant microenvironment. Herein, we report a …

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Amuc_1473 Links Gut Microbes to Skeletal Homeostasis and Counteracts Multifactorial Osteoporosis

Shan‐Shan Rao, Hai‐Jin Zeng, Zun Wang, Chun‐Gu Hong et autres

Emerging evidence suggests that gut microbiota-derived signals can influence distant organs including the skeleton, yet the key microbial effectors remain elusive. Here, we identify Amuc_1473, a previously uncharacterized protein enriched in extracellular vesicles (EVs) from the commensal bacterium Akkermansia muciniphila (Akk), as …

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Epigenetic brain reprogramming rejuvenates neuro-immune circuits to reverse Alzheimer’s disease pathology and systemic bone loss

Mei-dan Wan, Xixi Liu, Tengfei Wan, Yi-Wei Liu et autres

Alzheimer’s disease (AD) is characterized by progressive neurodegeneration, neuroinflammation, and systemic comorbidities, yet disease-modifying therapies remain elusive. Here, we show that partial epigenetic reprogramming via brain-restricted expression of Oct4, Sox2, and Klf4 (OSK) restores neuronal and neuroimmune homeostasis without loss of cellular …

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Plastisphere-driven pollutant enrichment and harmful bacteria proliferation: Emerging ecological risks to Danjiangkou reservoir's water security

Tao He, Zhimin Xu, Le-yi Cheng, Yi-Cai Zhang et autres

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Antibiotic-sensitive gut symbiont Turicibacter sanguinis alleviates constipation by enhancing short-chain fatty acids and tryptophan metabolism

Ruocen Tian, Xin‐Yue Hu, Leilei Yu, Fengwei Tian et autres

Abstract Turicibacter sanguinis is a prominent genus within the mammalian gut microbiota and is associated with various metabolic and gastrointestinal disorders, including overweight, obesity, irritable bowel syndrome (IBS) and constipation. However, the specific roles of T. sanguinis in host physiology remain unclear. …

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Engineered probiotic alleviates ulcerative colitis by inhibiting M1 macrophage polarization via glycolytic reprogramming

Chaoqun Lv, Xin‐Yue Hu, Xiang Li, Wen Shi et autres

Abstract Ulcerative colitis (UC) remains a significant therapeutic challenge due to its complex pathogenesis involving oxidative stress, immune dysregulation, and gut microbiota dysbiosis. Melanin, a natural biopolymer with robust anti‐inflammatory and antioxidant properties, presents a promising treatment avenue for UC. Probiotics, particularly …

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Highly sensitive detection of cervical cancer biomarker miR-21 using surface-enhanced Raman scattering (SERS)

Biqing Chen, Xinyu Yao, Shuwen Zhang, Xin‐Yue Hu et autres

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Recent advances in shape memory polymers for biomedical applications: Bridging macro- and micro-scale effects

Dongqi You, Lining Lin, Minyi Dong, Yunhong Wu et autres

: Shape memory polymers (SMPs) are a class of materials capable of undergoing deformation in response to external stimuli, and their unique shape-changing properties offer vast potential for applications in the biomedical field. Based on the dimensionality of the shape memory effect …

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Heavy Metal Ion Detection Based on Lateral Flow Assay Technology: Principles and Applications

Xiaobo Xie, Xin‐Yue Hu, Xin Cao, Qianhui Zhou et autres

Heavy metal ions pose a significant threat to the environment and human health due to their high toxicity and bioaccumulation. Traditional instrumentations, although sensitive, are often complex, costly, and unsuitable for on-site rapid detection of heavy metal ions. Lateral flow assay technology …

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Ultrasmall ruthenium nanoparticles with enhanced and tunable multienzyme-like activity for periodontitis treatment

Yangjie Shao, Pengpeng Xue, Dongqi You, Mingjian Zhu et autres

Periodontitis is an inflammatory disease caused by oxidative stress and initiated by bacterial infection. The endogenous enzyme system is dysfunctional in the periodontitis microenvironment. Currently, traditional clinical treatment cannot efficiently eliminate bacteria or relieve inflammation. To address this issue, we developed ultrasmall …

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Chitinase AbChi1 acts with the carbohydrate-binding module AbCbm1 to regulate mycelial growth in Agaricus bisporus

Yizhou Liu, Minhao Xie, Xin‐Yue Hu, Jintao Sun et autres

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Single-Molecule Macrocyclic Carrier Overcomes the Direct Transmembrane of Medium-Sized Cargoes

Xiaoxue Hou, Xin‐Yue Hu, Yang Wang, Huanyu Wang et autres

Direct transmembrane transport plays an important role in the biomedical field. Although well-established methods exist for the direct membrane transport of small-sized cargoes (e.g., water and ions) and large-sized cargoes (e.g., proteins, DNAs, polysaccharides), they are challenging to directly apply to medium-sized …

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