Luca Palmieri

Robotic surgery across surgical specialties: an Italian survey on implementation, training, and satisfaction levels among trainees and young attendings: on behalf of the Italian Multispecialty Society of Young Surgeons (SPIGC)

Francesco Giudice, Valerio Santarelli, Giulia Fiori, Sara Mastrovito et autres

European surgical institutions have been recently criticized for the insufficient endorsement of standardized robotic training curricula. In the present study, we report the results of a nationwide survey on the status of robotic surgery training and satisfaction across trainees from multiple surgical …

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Integrated expression profiling of trophoblast cell-surface antigen 2 (TROP2), folate receptor alpha (FRα), and human epidermal growth factor receptor 2 (HER2) in endometrial Cancer across molecular classes, genomic alterations, and histologic subtypes

Orazio De Tommasi, Luca Palmieri, Stefania Bellone, Natalia Buza et autres

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Preclinical in vitro and in vivo activity of trastuzumab deruxtecan against ERBB2-mutated cervical carcinomas with low HER2 expression

Namrata Sethi, Sarah Ottum, Stefania Bellone, Cem Demirkiran et autres

Objective: Somatic HER2 mutations occur in up to 6% of cervical cancer patients and are associated with poor prognosis. We explored the activity of trastuzumab deruxtecan (T-DXd) as a novel targeted therapy against HER2-mutated primary cervical cancer cell lines and xenografts with …

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Preclinical activity of tisotumab vedotin, an antibody–drug conjugate targeting tissue factor, in uterine serous carcinoma

Sarah Ottum, Namrata Sethi, Stefania Bellone, Cem Demirkiran et autres

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Ultrasound-first, anatomy-based algorithm to tailor the extent of hysterectomy in placenta accreta spectrum

Luca Palmieri, Giancarlo Paradisi, Daniela Romualdi, Luigi Selvaggi et autres

Placenta accreta spectrum (PAS) represents one of the most challenging scenarios in obstetric surgery, with cesarean hysterectomy remaining the standard approach in cases of suspected placenta percreta. However, objective and reproducible criteria to guide the extent of hysterectomy, particularly the decision to …

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Prognostic significance of lymphovascular space invasion extent across molecular classes in early-stage endometrial cancer: A large retrospective analysis

Ilaria Capasso, Emanuele Perrone, Rossella Letizia Mancusi, Matteo Loverro et autres

BACKGROUND: The prognostic role of lymphovascular space invasion (LVSI) in endometrial cancer (EC) remains poorly defined across molecular subgroups. We evaluated the impact of LVSI extent in a large cohort of stage I-II EC classified according to molecular profiling. METHODS: Patients with …

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Remarkable preclinical activity of Trastuzumab-Deruxtecan (T-DXd) in FISH-negative, HER2 IHC 1+ and 2+ expressing primary endometrial cancer cell lines and xenografts

Luca Palmieri, Stefania Bellone, Cem Demirkiran, Tobias MP Hartwich et autres

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Abstract 6386: Small bowel obstruction and short bowel syndrome may impair the efficacy of Avutometinib and Defactinib in recurrent low grade serous ovarian cancer: A case report.

Sarah Ottum, Luca Palmieri, Victoria Ettorre, Tobias Hartwich et autres

Abstract The treatment of recurrent low grade serous ovarian cancer (LGSOC) is a challenge, but when complicated by recurrent small bowel obstructions (SBO) and/or major small bowel resections, the decreased absorption/efficacy of oral medications must be considered. We report the case of …

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Response regarding “Folate receptor alpha as a successful biomarker in the treatment of low-grade serous ovarian cancer patients using pre-clinical and clinical models” by Wu et al

Victoria M. Ettorre, Natália Buza, Luca Palmieri, Alessandro Davide Santin

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Improving endometrial cancer assessment by combining the new technique of genomic profiling with surgical extra uterine disease assessment (EUGENIE)

Rita Trozzi, Luigi Congedo, Giovanni Esposito, Giulia Pellecchia et autres

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Integrated mutational landscape analysis of endometrial stromal sarcoma

Tobias MP Hartwich, Seungji Choi, Ayoung Hwang, Stefania Bellone et autres

Endometrial stromal sarcoma (ESS) is a rare uterine malignancy with limited treatment options. We performed integrated whole-genome, whole-exome, and transcriptome sequencing on 80 ESS tumors, comprising 32 low-grade (LG) and 48 high-grade (HG) tumors, to characterize their genetic landscape. The overall mutation …

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Robotic secondary cytoreduction in recurrent ovarian cancer: a tailored approach for kidney transplant recipients

Silvio Andrea Russo, Riccardo Oliva, Camilla Certelli, Sara Ammar et autres

Background: The rate of kidney transplantation has been steadily increasing worldwide, accompanied by significant improvements in post-transplant survival rates. However, transplant recipients have a higher incidence of malignancies compared with the general population, and their oncological management often poses unique challenges. In …

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