O. Girolamo

Acetylcholine coronary vasospastic responses evaluated via a hydrodynamic model

O. Girolamo, Navid Freidoonimehr, Robert Tavella, T Atkins et autres

Abstract Background Acetylcholine (ACh) provocation testing may identify epicardial or microvascular coronary vasospasm. However, delineation of these diagnoses is difficult in current clinical practice, warranting investigation of physiological changes. Aim To evaluate epicardial and microvascular resistance during ACh provocation using a novel …

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Functional coronary angiogram findings in angina with non-obstructive coronary arteries patients with coronary slow flow

O. Girolamo, Muhammad Dzafir Ismali, Rosanna Tavella, Eng Lee Ooi et autres

• The Coronary Slow Flow Phenomenon (CSFP) is characterized by the slow passage of angiographic contrast in patients with angina and non-obstructive coronary artery disease (ANOCA), and is considered a marker for a coronary microvascular disorder. • The CSFP is usually defined …

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Acetylcholine Coronary Vasospastic Responses Evaluated via a Hydrodynamic Model

O. Girolamo, Navid Freidoonimehr, R. Tavella, Terence W. Atkins et autres

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A Novel Hydrodynamic Approach for the Evaluation of Microvascular Resistance during Provocative Spasm Testing

Navid Freidoonimehr, O. Girolamo, Tam Atkins, Bo Yang et autres

INTRODUCTION: Intracoronary acetylcholine provocative testing is the gold standard method for the assessment of epicardial and/or microvascular spasm, with the latter diagnosed when there are acetylcholine (ACh)-induced chest pain and ischaemic electrocardiogram changes in the absence of epicardial spasm. While epicardial spasm …

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Functional Coronary Angiography for the Diagnosis of Coronary Vasomotor Disorders

C. Zeitz, J. Spiro, A. Yong, Jamie Layland et autres

Microvascular and/or vasospastic angina are two common forms of coronary vasomotor disorders that may occur in patients with ischaemia and non-obstructed coronary arteries (INOCA) or myocardial infarction with non-obstructive coronary arteries (MINOCA). Functional coronary angiography involves invasive guidewire-based assessment of the coronary …

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The patient journey in chronic coronary syndromes with/without obstructive coronary arteries

Sarena La, Rosanna Tavella, Jing Wu, John A. Spertus et autres

BACKGROUND AND AIMS: In patients undergoing invasive coronary angiography for the investigation of angina, the management pathways for obstructive coronary artery disease (CAD) are well described, whereas the clinical and diagnostic journey of patients with Angina with Non-Obstructive Coronary Arteries (ANOCA) has …

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Should the Right Coronary Artery Be Routinely Assessed During Provocative Spasm Testing?

O. Girolamo, Rosanna Tavella, David Di Fiore, A. Sheikh et autres

Background/Objectives: The diagnosis of coronary artery spasm (CAS) frequently requires invasive provocation testing, typically utilising acetylcholine (ACh). Although the left coronary artery (LCA) is routinely assessed as a part of the testing protocol, assessment of the right coronary artery (RCA) is often …

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Chronic Coronary Syndromes with/without obstructive coronary arteries: are there differences in ongoing chest pain?

S. La, Rosanna Tavella, Junfang Wu, John A. Spertus et autres

Abstract Background Stable coronary artery disease (CAD) is the archetype chronic coronary syndrome, clinically manifesting as angina with obstructive CAD on angiography and managed via evidence-based guidelines. In contrast, patients with Angina with Non-Obstructive Coronary Arteries (ANOCA) are often diagnosed with ‘non-specific …

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Coronary slow flow as measured by corrected TIMI frame counts is associated with impaired microvascular resistance

O. Girolamo, Muhammad Dzafir Ismali, Rosanna Tavella, Eng Lee Ooi et autres

Abstract Background The Coronary Slow Flow Phenomenon (CSFP) reflects an increased resting microvascular resistance and has been defined as a corrected thrombolysis in myocardial infarction frame count (cTFC) >27 in the in the absence of obstructive coronary artery disease (CAD). However, there …

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Chronic Coronary Syndrome With / Without Obstructive Coronary Arteries—Are There Differences in Ongoing Chest Pain?

S. La, Rosanna Tavella, J. Wu, John A. Spertus et autres

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Combined large Vessel and Microvascular Acetylcholine-Induced Spasm—A New Coronary Vasomotor Dysfunction Endotype

O. Girolamo, Navid Freidoonimehr, R. Tavella, A. Sheikh et autres

Coronary Slow Flow as Measured by Corrected TIMI Frame Counts is Associated With Impaired Microvascular Resistance

O. Girolamo, Muhammad Dzafir Ismali, R. Tavella, Eng Lee Ooi et autres

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