Yanrong Wei

A Molecularly Anchored Spatial Transcriptomic Framework for Precise CA1–Subiculum Parcellation and Region-Resolved Analysis in Alzheimer’s Disease

Youzhe He, Yanrong Wei, Pan Wang, Chunyu Huang et autres

BACKGROUND: The precise molecular delineation of the interface between the Subiculum (Sub) and cornu ammonis 1 (CA1) is a challenge in hippocampal research, as conventional cytoarchitectural boundaries are often ambiguous and limit reproducible regional annotation. Here, we developed a molecularly anchored spatial …

Botswana, cn (code pays fourni par la source)

Characterization of functional human-specific regulatory elements in prefrontal cortical cells

Bufan Jin, Langjian Zhu, Huizhong Chang, Yanrong Wei et autres

Publisher of over 50 scientific journals across the life, physical, earth, and health sciences, both independently and in partnership with scientific societies including Cell, Neuron, Immunity, Current Biology, AJHG, and the Trends Journals.

Gene expression profiling enables refined parcellation of cortical layers in the heterogeneous human cerebral cortex

Yanrong Wei, Youzhe He, Yuyang Liu, Langjian Zhu et autres

BACKGROUND: Precise delineation of cortical layers is fundamental for understanding human brain organization, cell-type architecture, and disease-related tissue alterations. However, traditional anatomy-based methods often lack molecular resolution and suffer from inter-observer subjectivity. METHODS: Here, we present gene expression-defined cortical layers (GD-Ls) using …

cn (code pays fourni par la source)

Characterization of functional human-specific regulatory elements in prefrontal cortical cells

Bufan Jin, Langjian Zhu, Huizhong Chang, Yanrong Wei et autres

Understanding how human-specific cis-regulatory elements (CREs) drive gene expression in the adult brain remains elusive. Here, we profile the prefrontal cortex (PFC) of adult human, macaque, and mouse using single-nucleus transcriptomic (106,266 cells) and genome-wide chromatin accessibility (212,099 cells) assays, showing human-specific …

cn (code pays fourni par la source)

Yizong Tongluo formula attenuates idiopathic pulmonary fibrosis and inflammatory injury by inhibiting HIF-1α/LSH/SCD1-mediated ferroptosis

Xin Ma, Xin Wang, Daobin Jiang, Yiminnuer Tuerxun et autres

Background Idiopathic pulmonary fibrosis (IPF) is a progressive disease characterized by chronic inflammation, aberrant tissue remodeling, and hypoxia. In traditional Chinese medicine (TCM), it is classified as Qi deficiency–blood stasis syndrome. The mechanism of Yizong Tongluo Formula (YZTLF), a Traditional Chinese Medicine …

cn (code pays fourni par la source)

From the brain cell atlas to precision neurology: a review of the application of AI-driven multi-omics in brain science

Youzhe He, Yanrong Wei, Jingxi Zhi, C J Huang et autres

Recent advances in multi-omics technologies have catalyzed the construction of comprehensive brain cell atlases, providing essential data foundations for artificial intelligence (AI)-driven analyses in precision neurology. This review systematically examines how the integration of AI with single-cell multi-omics and spatial multi-omics advances …

Botswana, cn (code pays fourni par la source)

A Population-scale Single-cell Spatial Transcriptomic Atlas of the Human Cortex

Lei Han, Zhen Liu, Lifang Wang, Yuxuan Liu et autres

Summary The genetic and spatial determinants of cell type diversity in human cerebral cortices remain poorly defined. Here, we present a population-level single-cell spatial transcriptomic atlas of human cortices from 71 donors across the lifespan. We identified 906 layer-specific genes showing conserved …

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Molecular pathways and diagnosis in spatially resolved Alzheimer’s hippocampal atlas

Pan Wang, Lei Han, Lifang Wang, Quyuan Tao et autres

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Single-cell spatial transcriptomic atlas of the whole mouse brain

Lei Han, Zhen Liu, Zehua Jing, Yuxuan Liu et autres

cn, Botswana (code pays fourni par la source)

Single-cell spatial transcriptome reveals pathological features of human hippocampus with sclerosis

Lifang Wang, Xingjie Li, Yuyang Liu, Bufan Jin et autres

Abstract More than half of epileptic patients ultimately turned to intractable epilepsy. Mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS), the most common type of intractable epilepsies, whose pathological mechanism remains elusive. Here, using 42 human hippocampal samples from surgical donors of …

cn, Botswana (code pays fourni par la source)

Altered immune response is associated with sex difference in vulnerability to Alzheimer's disease in human prefrontal cortex

Huiying Wen, Youzhe He, Yuanchun Tang, Quyuan Tao et autres

Alzheimer's disease (AD) is a neurodegenerative disorder with a higher risk incidence in females than in males, and there are also differences in AD pathophysiology between sexes. The role of sex in the pathogenesis of AD may be crucial, yet the cellular …

cn (code pays fourni par la source)

Expression characteristics and potential function of non-coding RNA in mouse cortical cells

Yanrong Wei, Junjie Lei, Yujie Peng, Huizhong Chang et autres

Non-coding RNAs (ncRNAs) play essential regulatory functions in various physiological and pathological processes in the brain. To systematically characterize the ncRNA profile in cortical cells, we downloaded single-cell SMART-Seq v4 data of mouse cerebral cortex. Our results revealed that the ncRNAs alone …

cn, it (code pays fourni par la source)