Renee Reams

Abstract 4198: Integrative single-cell transcriptomics and computational docking identify CCL18 as an immunomodulatory target in prostate cancer

Edwige Flore Gouegni, Gebre-Eziagbher Kiros, Renee Reams, Diana J. Wilke et autres

Abstract Background: Prostate adenocarcinoma (PRAD) remains a major cause of cancer morbidity in men, driven by cellular heterogeneity and immune evasion. Single-cell RNA sequencing (scRNA-seq) enables high-resolution profiling of tumor and immune states to uncover cell-specific therapeutic targets. This study integrates scRNA-seq, …

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Abstract 4468: Modified 5-FU immunoliposome targeting EGFR-expressing pancreatic tumors: In vitro and in vivo evaluation

Esther Frimpong, Raviteja Bulusu, Joy C. Okoro, Xue You Zhu et autres

Abstract Purpose: Epidermal growth factor receptor (EGFR) is vital in tumor growth, invasion, and metastasis. Many pancreatic tumors express EGFR, making it important in targeted therapy. XYZ-I-73, a novel 5-Fluorouracil (5-FU) analog formed from conjugating lauroyl chloride to 5-fluorocytosine from our previous …

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Abstract 4477: Biological evaluation of EGFR- conjugated liposomal drug delivery system for enhanced targeting of pancreatic cancer

Raviteja Bulusu, Joy C. Okoro, Esther Frimpong, Saunjoo L. Yoon et autres

Abstract Purpose: The purpose of this study is to entrap and characterize a potential lead compound (heptyl (5-fluoro-2-oxo-1-(tetrahydrofuran-2-yl)-1, 2-dihydropyrimidine-4-yl) carbamate (AGY2) into antibody-conjugated liposomal drug delivery system (AGY2-EGFR LDDS) to target pancreatic cancer. Methods: The monoclonal antibody (Cetuximab) conjugated AGY2 loaded liposome …

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Abstract 3626: Deoxycytidine kinase (dCK) gene expression patterns and racial disparities: Findings from the Multiethnic Cohort study

Saunjoo L. Yoon, Sherise Chantell Rogers, David Daniel Bogumil, Edward Agyare et autres

Abstract Background: Significant disparities exist in pancreatic cancer outcomes across different racial and ethnic groups, with African Americans experiencing disproportionately higher incidence and mortality rates than other ethnic groups. The genetic underpinnings of these disparities, particularly concerning drug metabolism and treatment response, …

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Abstract 4475: Evaluation of targeted immunoliposomes encapsulating 4-N-hydroxylgemcitabine in EGFR-positive pancreatic cancer

Joy C. Okoro, Raviteja Bulusu, Esther Frimpong, Saunjoo L. Yoon et autres

Abstract Purpose: Pancreatic cancer (PCa) is a deadly malignancy that is challenging to treat. Gemcitabine (Gem) is a standard therapy in PCa treatment. Epidermal growth factor receptor (EGFR) is commonly overexpressed in PCa and contributes to tumor progression and metastasis. Gem is …

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Abstract 45: PDX technology transfer: NCI cancer center to HBCU

Teni O. Akin-Olugbemi, D Lucas, Romell Stone, Esther Frimpong et autres

We profile a technology transfer process between two partnering research institutions and the early outcomes. The Partnerships to Advance Cancer Health Equity (PACHE) program seeks to increase cancer research at HBCUs via collaborations with NCI-designated cancer centers. One such partnership, the Florida-California …

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Somatic Genomic Profiling of Pancreatic Ductal Adenocarcinomas From a Diverse Cohort of Patients

Andrea N. Riner, Enrique I. Velazquez-Villarreal, Seeta Rajpara, Jing Qian et autres

OBJECTIVES: Black/African American (B/AA) pancreatic ductal adenocarcinoma (PDAC) patients have worse clinical outcomes than White patients and are underrepresented in genomic databases. We aimed to expand our understanding of the PDAC somatic landscape from a diverse cohort. MATERIALS AND METHODS: Formalin-fixed paraffin-embedded …

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Mentoring Minority Cancer Researchers of Tomorrow: Comparison of the Face-to-Face, Virtual, and Hybrid Training Methods of the CaRE2 Summer Cancer Research Education and Training Program

Bereket Mochona, Kinfe Ken Redda, Ite A. Laird‐Offringa, John M. Allen et autres

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Social network analysis of the CaRE2 health equity center: Team science in full display

Miriam O. Ezenwa, Thomas Bryan Smith, Joyce M. Richey, Ukamaka D. Smith et autres

Abstract Cancer health disparities that exist in the Black or African American and Hispanic or Latino/x communities are scientific challenges, yet there are limited team science approaches to mitigate these challenges. This article's purpose is to evaluate the team science collaborations of …

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Somatic genomic profiling of pancreatic ductal adenocarcinomas from a diverse cohort of patients

Andrea N. Riner, Enrique I. Velazquez-Villarreal, Sanjay M Rajpara, Jing Qian et autres

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Florida-California Cancer Research, Education and Engagement (CaRE 2 ) Health Equity Center: Structure, Innovations, and Initial Outcomes

Renee Reams, Folakemi T. Odedina, John David Carpten, Kinfe Ken Redda et autres

Introduction The Florida-California Cancer Research, Education, and Engagement (CaRE 2 ) Health Equity Center is a triad partnership committed to increasing institutional capacity for cancer disparity research, the diversity of the cancer workforce, and community empowerment. This article provides an overview of …

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Abstract 1274: Prognostic relevance of ZnF 649 in clear cell carcinoma

Renee Reams, Simone O. Heyliger, Marilyn D. Saulsbury, Karam F. A. Soliman

Abstract Clear cell renal carcinoma (ccRCC) is the most common form of neoplastic disease affecting the kidneys that accounts for at least 70% of all kidney cancers. Given its resistance to medications and high mortality at later stages, there is a need …

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