LINGO2 expression on T cells promotes anti-helminth immunity

Le résumé fourni par la source

Abstract T helper type 2 (TH2) cells are critical for clearance of parasitic helminth infections. Their coordinated efforts harness cellular and molecular pathways to expel worms, resolve intestinal inflammation and drive tissue repair. Yet the mechanisms that control TH2 cell activation, maintenance, and downregulation remain unknown. We recently demonstrated that Leucine rich repeat and Ig domain containing 2 (LINGO2) can function as a receptor for the mucosal reparative cytokine, Trefoil factor 3, to limit epithelial damage, colitic disease and immunopathology. Because LINGO2 is broadly expressed in both hematopoietic and non-hematopoietic cell lineages, this study specifically addressed whether LINGO2 expression in the T cell compartment served a biologically important function in host protection against the parasitic helminth Trichuris muris. Data show that mice selectively deficient for LINGO2 in T lymphocytes (CD4Cre+ LINGO2flox/flox) had significantly higher numbers of adult worms in the cecum, parasite eggs in the stool and colon immunopathology compared to CD4Cre+ or LINGO2flox/flox controls. Intriguingly, after Trichuris infection, CD4Cre+ LINGO2flox/flox mice had significantly fewer GATA3+ TH2 cells and expressed significantly increased interferon gamma levels in the mesenteric lymph node. Taken together, this work highlights a previously unrecognized cell-intrinsic role for LINGO2 in controlling T cell responses that critically shapes the outcome of helminth infection.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.