Teng-Jin Khoo

Predicted antiviral potential of phytochemicals prolific in Cleistanthus bracteosus Jabl. and essential oils of Artemisia scoparia and Thuja orientalis against Nipah virus and Human metapneumovirus: An AI-driven in-silico study

Mackingsley Kushan Dassanayake, Teng-Jin Khoo, Chien Hwa Chong, Mohammed Tahir Ansari et autres

The recent Nipah virus (NiV) epidemic and human metapneumovirus (hMPV) outbreak have had a significant impact on human health and society worldwide. The attachment glycoprotein (G) and fusion glycoprotein (F0) of NiV and hMPV are essential for pathogenesis and are potentially pronounced …

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EGFR as a biomarker in colorectal Cancer: An electrochemical biosensing approach

Mohammed Khaled Bin Break, Rahamat Unissa Syed, Weiam Hussein, Muhammad Nawaz et autres

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Antibacterial potency of mid-polar extracts obtained from Malaysian plant Parkia speciosa against human pathogenic bacteria

Mackingsley Kushan Dassanayake, Christophe Wiart, Rachael C. Symonds, Teng-Jin Khoo et autres

Plants contain a wide variety of bioactive compounds, which have attracted the interest of researchers in finding novel sources of natural medicine. In the following paper, we aim to evaluate the antibacterial potential of extract fractions associated with Parkia speciosa pods and …

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Antibacterial phenolic compounds from the flowering plants of Asia and the Pacific: coming to the light

Mazdida Sulaiman, Layane Ebehairy, Veeranoot Nissapatorn, Mohammed Rahmatullah et autres

CONTEXT: The emergence of pan-resistant bacteria requires the development of new antibiotics and antibiotic potentiators. OBJECTIVE: This review identifies antibacterial phenolic compounds that have been identified in Asian and Pacific Angiosperms from 1945 to 2023 and analyzes their strengths and spectra of …

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Correction: Dassanayake et al. Synergistic Field Crop Pest Management Properties of Plant-Derived Essential Oils in Combination with Synthetic Pesticides and Bioactive Molecules: A Review. Foods 2021, 10, 2016

Mackingsley Kushan Dassanayake, Chien Hwa Chong, Teng-Jin Khoo, Adam Figiel et autres

In the original publication [...].

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CCDC 2295818: Experimental Crystal Structure Determination

Mohammed Khaled Bin Break, Sree Vaneesa Nagalingam, Kok Wai-Ling, Weiam Hussein et autres

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, …

Synthesis, crystal structure, Hirshfeld surface analysis and DFT calculations of novel clusianone analogues as anticancer agents that downregulate β-tubulin and Cdk1/Cyclin B1

Mohammed Khaled Bin Break, Sree Vaneesa Nagalingam, Kok Wai-Ling, Weiam Hussein et autres

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Synthesis, Crystal Structure, Antibacterial and In Vitro Anticancer Activity of Novel Macroacyclic Schiff Bases and Their Cu (II) Complexes Derived from S-Methyl and S-Benzyl Dithiocarbazate

Mohammed Khaled Bin Break, Tan Yew Fung, May Zie Koh, Wan Yong Ho et autres

A series of novel macroacyclic Schiff base ligands and their Cu (II) complexes were synthesised via reacting dicarbonyls of varying chain lengths with S-methyl dithiocarbazate (SMDTC) and S-benzyl dithiocarbazate (SBDTC) followed by coordination with Cu (II) ions. X-ray crystal structures were obtained …

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Molecular Docking and In-Silico Analysis of Natural Biomolecules against Dengue, Ebola, Zika, SARS-CoV-2 Variants of Concern and Monkeypox Virus

Mackingsley Kushan Dassanayake, Teng-Jin Khoo, Chien Hwa Chong, Patrick Di Martino

antiviral potential of six bacterial antimicrobial peptides (AMPs), two phytochemicals (silvestrol, andrographolide), and two bacterial secondary metabolites (lyngbyabellin A, hapalindole H) against dengue virus, Zika virus, Ebola virus, the major variants of SARS-CoV-2 and monkeypox virus. The comparison of docking scores obtained …

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Isolation and Characterization of Werneria Chromene and Dihydroxyacidissimol from Burkillanthus malaccensis (Ridl.) Swingle

Masyitah Zulkipli, Nuzum Mahbub, Ayesha Fatima, Stefanie Lim Wan-Lin et autres

The secondary metabolites of endemic plants from the Rutaceae family, such as Burkillanthusmalaccensis (Ridl.) Swingle from the rainforest of Malaysia, has not been studied. Burkillanthusmalaccensis (Ridl.) Swingle may produce antibacterial and antibiotic-potentiating secondary metabolites. Hexane, chloroform, and methanol extracts of leaves, bark, …

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Antibiotic resistance modifying ability of phytoextracts in anthrax biological agent Bacillus anthracis and emerging superbugs: a review of synergistic mechanisms

Mackingsley Kushan Dassanayake, Teng-Jin Khoo, Jia An

BACKGROUND AND OBJECTIVES: The chemotherapeutic management of infections has become challenging due to the global emergence of antibiotic resistant pathogenic bacteria. The recent expansion of studies on plant-derived natural products has lead to the discovery of a plethora of phytochemicals with the …

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Synergistic Field Crop Pest Management Properties of Plant-Derived Essential Oils in Combination with Synthetic Pesticides and Bioactive Molecules: A Review

Mackingsley Kushan Dassanayake, Chien Hwa Chong, Teng-Jin Khoo, Adam Figiel et autres

The management of insect pests and fungal diseases that cause damage to crops has become challenging due to the rise of pesticide and fungicide resistance. The recent developments in studies related to plant-derived essential oil products has led to the discovery of …

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