Rachel S. Gormal

Extracellular vesicle-associated α-synuclein disrupts retrograde signalling-endosome trafficking in recipient neurons

Frédéric A. Meunier, Barbara Duda, Saber Saber, Vanessa Lanoue et autres

au, sg, be, ru (code pays fourni par la source)

Single-Molecule Imaging of Endogenous Proteins

Anusha Malapaka, Frédéric A. Meunier, Rachel S. Gormal

au (code pays fourni par la source)

Fluorescent Peptide Tracers for Simultaneous Oxytocin Receptor Activation and Visualization

Monika Perisic, Predrag Kalaba, Rachel S. Gormal, Maja Zupančič et autres

The oxytocin receptor (OTR) regulates critical physiological functions and has been implicated in a range of diseases, including psychiatric and neurodevelopmental disorders such as autism spectrum disorder. However, a lack of reliable molecular tools hampers the progress in understanding OTR's mechanistic roles …

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Fluoreszenzmarkierte Peptidtracer zur simultanen Aktivierung und Bildgebung des Oxytocinrezeptors

Monika Perisic, Predrag Kalaba, Rachel S. Gormal, Maja Zupančič et autres

Abstrakt Der Oxytocinrezeptor (OTR) reguliert wichtige physiologische Prozesse und ist mit einer Reihe von Erkrankungen assoziiert, darunter psychiatrischen und neuroentwicklungsbedingten Störungen wie Autismus‐Spektrum‐Störungen. Der Mangel an verlässlichen molekularen Werkzeugen stellt ein zentrales Hindernis für die Aufklärung der mechanistischen Rollen des OTR in …

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Transmitted α-synuclein extracellular vesicles downregulate axonal flux of retrograde carriers in recipient neurons

Saber H. Saber, Vanessa Lanoue, Adekunle T. Bademosi, Rachel S. Gormal et autres

Abstract α-Synuclein (α-syn) is a cytosolic protein located in nerve terminals and is involved in several neurodegenerative diseases such as Parkinson’s disease. Recent studies have demonstrated that α-syn can be transmitted from neuron to neuron via exosomal release, thereby contributing to the …

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Nanoscale spatiotemporal cluster analysis of expressed and endogenous proteins

Rachel S. Gormal, Tristan P. Wallis, Alex J. McCann, Kye Kudo et autres

au (code pays fourni par la source)

Lysine myristoylation mediates long-term potentiation via membrane enrichment of synaptic plasticity effectors

Benjamin John Matthews, Shawn Steeves, Isaac Oluwatobi Akefe, Noorya Yasmin Ahmed et autres

Abstract Synaptic plasticity underlying long-term memory is associated with the generation of saturated free fatty acids (sFFAs) –particularly myristic acid– from membrane phospholipids by the phospholipase A1 isoform DDHD2. However, the mechanism through which myristic acid contributes to synaptic plasticity remains elusive. …

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Dynamin independent endocytosis is an alternative cell entry mechanism for multiple animal viruses

Ravi Ojha, Anmin Jiang, Elina Mäntylä, Tania Quirin et autres

Mammalian receptor-mediated endocytosis (RME) often involves at least one of three isoforms of the large GTPase dynamin (Dyn). Dyn pinches-off vesicles at the plasma membrane and mediates uptake of many viruses, although some viruses directly penetrate the plasma membrane. RME is classically …

fi, au, ch, be, gb, fr (code pays fourni par la source)

SV2A controls the surface nanoclustering and endocytic recruitment of Syt1 during synaptic vesicle recycling

Christopher L. Small, Callista B. Harper, Anmin Jiang, Christiana Kontaxi et autres

Abstract Following exocytosis, the recapture of plasma membrane‐stranded vesicular proteins into recycling synaptic vesicles (SVs) is essential for sustaining neurotransmission. Surface clustering of vesicular proteins has been proposed to act as a ‘pre‐assembly’ mechanism for endocytosis that ensures high‐fidelity retrieval of SV …

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Author response for " SV2A controls the surface nanoclustering and endocytic recruitment of Syt1 during synaptic vesicle recycling"

Christopher L. Small, Callista B. Harper, Anmin Jiang, Christiana Kontaxi et autres

Dynamin1 long- and short-tail isoforms exploit distinct recruitment and spatial patterns to form endocytic nanoclusters

Anmin Jiang, Kye Kudo, Rachel S. Gormal, Sevannah A. Ellis et autres

Endocytosis requires a coordinated framework of molecular interactions that ultimately lead to the fission of nascent endocytic structures. How cytosolic proteins such as dynamin concentrate at discrete sites that are sparsely distributed across the plasma membrane remains poorly understood. Two dynamin-1 major …

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Synapsin 2a tetramerisation selectively controls the presynaptic nanoscale organisation of reserve synaptic vesicles

Shanley F. Longfield, Rachel S. Gormal, Matis Feller, Pierre Parutto et autres

Abstract Neurotransmitter release relies on the regulated fusion of synaptic vesicles (SVs) that are tightly packed within the presynaptic bouton of neurons. The mechanism by which SVs are clustered at the presynapse, while preserving their ability to dynamically recycle to support neuronal …

au, fr, sg, gb (code pays fourni par la source)