David Mansouri

Faecal haemoglobin-based referral and investigation prioritisation is associated with colorectal cancer-specific survival in symptomatic patients: a retrospective observational study

Stephen Thomas McSorley, Paul Burton, Donna J. Chantler, Mark Johnstone et autres

BACKGROUND: Current BSG/ACPGBI and NICE guidance recommends that faecal haemoglobin (f-Hb) ≥10 ug/g measured by faecal immunochemical test (FIT) in symptomatic patients should prompt referral through cancer prioritised diagnostic pathways. However, limited long term CRC outcome data exist. This study compared CRC …

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Outcomes of a novel multidisciplinary approach to delivering sacral neuromodulation services away from the operating theatre

Kirsty Wright, Peter Ishak, David Mansouri, Graham Mackay

Does robotic assisted surgery mitigate obesity related systemic inflammatory response and clinical outcomes in left sided colorectal cancer resections?

Abigail R. Ingham, Stephen Thomas McSorley, Donald McMillan, David Mansouri et autres

) is rapidly increasing worldwide with 26% of the UK population being obese and 38% being overweight. Obesity is intimately related to several life-limiting conditions including colorectal cancer (CRC). Obese patients have a higher degree of perioperative systemic inflammatory response (SIR) and …

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Does robotic assisted surgery mitigate obesity related systemic inflammatory response and clinical outcomes in left sided colorectal cancer resections?

Stephen Thomas McSorley, Donald C. McMillan, David Mansouri, David Y. Chong et autres

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Management of subcutaneous abscesses: prospective cross-sectional study (MAGIC)

Stephen J. Chapman, Josh Burke, Jack A. Helliwell, Mikolaj R. Kowal et autres

Subcutaneous abscesses are pus-filled cavities within the dermis and subdermal layers caused by a local bacterial infection, most commonly Staphylococcus aureus1. They are a common presentation, with an incidence of 433 per 100 000 presentations in community practice, leading to 236 per …

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CT-derived body composition and differential association with age, TNM stage and systemic inflammation in patients with colon cancer

Allan Matthew Golder, Michael J. Ferguson, Paul J. McMillan, David Mansouri et autres

Low skeletal muscle index/density (SMI/SMD) is prevalent in cancer, adversely prognostic and associated with tumour stage and the systemic inflammatory response (SIR). Age and SMI/SMD has not been widely studied. The present study analyses the association between age and SMI/SMD after adjustment …

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397 Perioperative Outcomes from Robotic-Assisted Colorectal Cancer Surgery in High BMI Patients

Andrzej Wróbel, Andreas Ingham, Chia Yew Kong, Stephen J. McSorley et autres

Abstract Aim Provide insight into the short-term outcomes associated with high BMI patients undergoing robotic-assisted surgery for colorectal cancer. Method Retrospective review of colorectal cancer patients undergoing robotic anterior resection or Abdominoperineal resection from May 2021 to March 2023. Explanatory variables were …

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Robotic-assisted surgery for left-sided colon and rectal resections is associated with reduction in the postoperative surgical stress response and improved short-term outcomes: a cohort study

Abigail R. Ingham, Chia Yew Kong, Tin-Ning Wong, Stephen Thomas McSorley et autres

INTRODUCTION: There is growing evidence that the use of robotic-assisted surgery (RAS) in colorectal cancer resections is associated with improved short-term outcomes when compared to laparoscopic surgery (LS) or open surgery (OS), possibly through a reduced systemic inflammatory response (SIR). Serum C-reactive …

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The relationship between systemic inflammatory response, screen detection and outcome in colorectal cancer

Mark Scott Johnstone, Stephen Thomas McSorley, Donald C. McMillan, Paul G. Horgan et autres

AIM: A raised systemic inflammatory response correlates with poorer colorectal cancer (CRC) outcomes. Faecal immunochemical test bowel screening aims to detect early-stage disease. We assessed the relationship between systemic inflammatory response, screen detection and CRC survival. METHOD: testing and survival with Cox …

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Adverse Tumour and Host Biology May Explain the Poorer Outcomes Seen in Emergency Presentations of Colon Cancer

Allan Matthew Golder, Owen Conlan, Donald C. McMillan, David Mansouri et autres

OBJECTIVE: To examine the association between tumor/host factors (including the systemic inflammatory response), mode of presentation, and short/long-term outcomes in patients undergoing curative resectional surgery for TNM I to III colon cancer. BACKGROUND: Emergency presentations of colon cancer are associated with worse …

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The association between KRAS mutational status, clinicopathological factors including the preoperative systemic inflammatory response and outcomes in TNM stage I-III colon cancer.

Allan Matthew Golder, Kathryn A.F. Pennel, David Mansouri, Paul G. Horgan et autres

193 Background: TNM Stage is the most significant prognostic indicator in colon cancer however other tumour and host factors (eg the systemic inflammatory response (SIR)) are associated with long-term outcomes. The relationship between the tumour and the host SIR remains poorly understood. …

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The relationship between the mode of presentation, CT‐derived body composition, systemic inflammatory grade and survival in colon cancer

Allan Matthew Golder, Ling Kwan Ernest Sin, Fatima Alani, Ala Alasadi et autres

BACKGROUND: Within colorectal cancer, the systemic inflammatory response (SIR) and CT-derived body composition, particularly the loss of lean muscle mass, are independently associated with oncological outcomes; however, no study has included both non-metastatic and metastatic disease. The present study analyses the association …

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