Accès ouvert
2025
preprint
OpenAlex
Aula Ammar, Amna Matly, Kimiya Kabiri Arani, Scott J. Murray et autres
Abstract Current post-polypectomy surveillance strategies rely on morphological features and fail to capture the biological heterogeneity that underlies early colorectal neoplasia. While the SWI/SNF subunit ARID1A is frequently altered in colorectal cancer, its clinical utility and biological role during the pre-malignant stage …
gb
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2025
conference-abstract
OpenAlex
Natalie C. Fisher, Sudhir B. Malla, Raheleh Amirkhah, Aula Ammar et autres
Abstract Background: Bowel cancer screening has increased detection of colorectal precursors. Despite this increased incidence, while transcriptional characterisation and molecular subtyping approaches are well established in colorectal tumours, similar biological discovery approaches in colorectal polyps have been limited. While some multi-omics studies …
gb
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Accès ouvert
2025
article
OpenAlex
Mark Scott Johnstone, Reiss Stoops, Alexander Tham, Emma C. Parsons et autres
BACKGROUND: Adherence to post-polypectomy surveillance is poor despite evidence that it is associated with lower risk of future colorectal cancer. METHODS: We evaluated 6,210 bowel screening participants between 2009-2016 in NHS Greater Glasgow and Clyde to assess potential barriers to post-polypectomy surveillance. …
gb
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Accès ouvert
2024
preprint
OpenAlex
Sara Samir Foad Al-Badran, Christopher J. Bigley, Mark Scott Johnstone, Aula Ammar et autres
ABSTRACT Objectives Adenomas are known precursors to colorectal cancer (CRC). Current UK post-polypectomy surveillance guidelines use polyp size, numbers, and histology to stratify the risk of patients developing metachronous polyps or CRC. However, these risk guidelines suffer from poor predictive value, often …
gb
(code pays fourni par la source)
2024
conference-abstract
OpenAlex
Gerard P. Lynch, Aula Ammar, Christopher J. Bigley, Mark Scott Johnstone et autres
Abstract Approximately 40% of patients are found to have polyps at bowel screening colonoscopy, which are associated with a higher risk of developing future polyps or colorectal cancer. The British Society of Gastroenterology 2020 (BSG20) guidelines stratify patients into high/low risk of …
gb
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Accès ouvert
2023
article
OpenAlex
Mark Scott Johnstone, Stephen Thomas McSorley, Donald C. McMillan, Paul G. Horgan et autres
AIM: A raised systemic inflammatory response correlates with poorer colorectal cancer (CRC) outcomes. Faecal immunochemical test bowel screening aims to detect early-stage disease. We assessed the relationship between systemic inflammatory response, screen detection and CRC survival. METHOD: testing and survival with Cox …
gb
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Accès ouvert
2023
article
OpenAlex
Mark Scott Johnstone, Stephen Thomas McSorley, ANDREW J. McMAHON
AIM: The recurrence risk associated with residual malignant cells (bowel wall/regional nodes) following T1 colorectal cancer (CRC) polypectomy must be weighed against operative morbidity. Our aim was to describe the management and outcomes of a large prospective cohort of T1 CRCs. METHOD: …
gb
(code pays fourni par la source)
Accès ouvert
2023
article
OpenAlex
Mark Scott Johnstone, Reiss Stoops, Gerard Lynch, Jennifer R. Hay et autres
BACKGROUND: After colorectal polypectomy, 20-50 per cent of patients develop metachronous polyps and some have increased colorectal cancer risk. British Society of Gastroenterology (BSG) 2020 guidelines recommend surveillance colonoscopy for high-risk patients based on index pathology. The aim of this study was …
gb
(code pays fourni par la source)
Accès ouvert
2023
conference-abstract
OpenAlex
Mark Scott Johnstone, Sara Samir Foad Al-Badran, Reiss Stoops, Jennifer R. Hay et autres
234 Background: Following colorectal polypectomy, 20-50% develop metachronous polyps, and some have increased colorectal cancer (CRC) risk. Surveillance colonoscopy is recommended to high-risk patients, based on index polyp number, histology and size. We aimed to assess if COX2, p53 and beta-catenin expression …
gb
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Accès ouvert
2023
conference-abstract
OpenAlex
Joanne Edwards, Sara Samir Foad Al-Badran, Lily Hillson, Aula Ammar et autres
232 Background: Following colorectal polypectomy, 20-50% of patients develop metachronous polyps, and a proportion have increased colorectal cancer (CRC) risk. However, there are currently no molecular biomarkers for predicting metachronous polyp risk. Constitutive activation of the Wnt signalling cascade is a hallmark …
gb
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Accès ouvert
2022
article
OpenAlex
Mark Scott Johnstone, Campbell MacLeod, Jayne Digby, Yassir Al‐Azzawi et autres
AIM: The faecal immunochemical test (FIT) for faecal haemoglobin (f-Hb) helps determine the risk of colorectal cancer (CRC) and has been integrated into symptomatic referral pathways. 'Safety netting' advice includes considering referral for persistent symptoms, but no published data exists on repeated …
gb
(code pays fourni par la source)
2022
conference-abstract
OpenAlex
Mark Scott Johnstone, Jayne Digby, Judith A Strachan, Campbell MacLeod et autres
Introduction The faecal immunochemical test (FIT) is used in symptomatic referral pathways to rule out colorectal cancer (CRC) with greater accuracy than symptoms alone. NICE DG30 suggests a faecal haemoglobin (f-Hb) threshold of 10ug/g to prompt urgent referral to secondary care. However, …
gb
(code pays fourni par la source)