María José Bonomi

Real-life management of stage III non-small cell lung cancer patients in Italy: the BE-PACIFIC observational study

Paolo Bironzo, Alessandro Morabito, Sonia Silipigni, Vincenzo Adamo et autres

BACKGROUND: Stage III non-small cell lung cancer (NSCLC) includes a heterogeneous group of patients with diverse disease presentation, biological portrait, and prognosis. Optimal management requires tailored approaches and multimodal strategies through a multidisciplinary team (MDT) decision-making process. The BE-PACIFIC study primarily aimed …

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A phase III randomized clinical trial of Gemcitabine and Nab-Paclitaxel as switch maintenance versus continuation of modified FOLFIRINOX as first-line chemotherapy in patients with advanced pancreatic cancer: The PANThEON Study

Carolina Sciortino, Federico Nichetti, Francesca Bergamo, Federica Palermo et autres

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Microvascular Invasion in Hepatocellular Carcinoma (Hcc): Implications and Strategy

Andrea Celotti, Machaon Bonafede, Gian Luca Baiocchi, Michele Tomasoni et autres

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Fluorescence-guided mesorectal nodes harvesting associated with local excision for early rectal cancer: technical notes

Ilaria Benzoni, Martina Fricano, Jessica Borali, Martina Bonafede et autres

BACKGROUND: The spread of colorectal cancer screening has increased the percentage of patients with early-stage rectal cancer; at least 30% of patients are diagnosed with a clinical-stage cT1 or pT1 after endoscopic excision. In this subgroup of patients, the real advantage of …

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Survival analysis of the non-metastatic cohort of the Italian Association for Medical Oncology (AIOM) Guideline Application in Real world: multi-Institutional Based survey of Adjuvant and first-Line pancreatic Ductal adenocarcinoma treatment in Italy (GARIBALDI)

M. Reni, M Milella, F. Bergamo, Mathilde Di Marco et autres

BACKGROUND: Non-metastatic pancreatic ductal adenocarcinoma (PDAC) presents a challenging scenario: the rarity of the disease, the limited number of completed prospective trials, and the shortcomings of comparability across series produce several controversial topics and unanswered questions. Guideline recommendations usually include all the …

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Survival analysis of the metastatic cohort of Italian Association of Medical Oncology (AIOM) GARIBALDI survey

M. Reni, Elisa Giommoni, F. Bergamo, Luigi Cavanna et autres

This analysis from the GARIBALDI study was aimed to address the role of center self-declared expertise, type and commitment on the overall survival (OS) of patients with metastatic Pancreatic Ductal Adenocarcinoma (mPDAC). Treatment-naïve patients ≥18-year with pathological diagnosis of mPDAC were enrolled. …

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Targeting HER2 in Gastroesophageal Adenocarcinoma: Molecular Features and Updates in Clinical Practice

María José Bonomi, Daniele Spada, Gian Luca Baiocchi, Andrea Celotti et autres

Gastroesophageal adenocarcinoma (GEA) is one of the principal causes of death related to cancer globally. Human epidermal growth factor receptor 2 (HER2) is a tyrosine kinase receptor which is found to be overexpressed or amplified in approximately 20% of GEA cases. In …

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Trans Anal Local Excision plus Indocyanine Green mesorectal nodal sampling in staging and treatment of rectal cancer

Ilaria Benzoni, Martina Fricano, Antonio Tarasconi, Andrea Celotti et autres

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1666P Non-metastatic cohort of the Italian Association for Medical Oncology (AIOM) guideline application in real-world: Multi-Institutional based survey of adjuvant and first-line pancreatic ductal adenocarcinoma treatment in Italy (GARIBALDI)

Carmine Pinto, Michèle Milella, Francesca Bergamo, Mariacristina Di Marco et autres

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Krukenberg Tumor Related to Gallbladder Cancer in a Young Woman: A Case Report and Review of the Literature

Giulia Grizzi, Michele Ghidini, Margherita Ratti, Marianna D’Ercole et autres

A gallbladder tumor is a rare condition, which usually spreads to the liver, lymph nodes, and other organs. A Krukenberg tumor, derived from the biliary tract and gallbladder cancers (GBCs), is an uncommon finding in routine clinical practice. Here, a case of …

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Circulating Tumor DNA in Gastric Adenocarcinoma: Future Clinical Applications and Perspectives

Giulia Grizzi, Massimiliano Salati, María José Bonomi, Margherita Ratti et autres

Gastric cancer (GC) is still one of the most aggressive cancers with a few targetable alterations and a dismal prognosis. A liquid biopsy allows for identifying and analyzing the DNA released from tumor cells into the bloodstream. Compared to tissue-based biopsy, liquid …

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Anti-Claudin Treatments in Gastroesophageal Adenocarcinoma: Mainstream and Upcoming Strategies

Giulia Grizzi, Kostantinos Venetis, Nerina Denaro, María José Bonomi et autres

Claudins (CLDNs) are a multigene family of proteins and the principal components of tight junctions (TJs), which normally mediate cell-cell adhesion and selectively allow the paracellular flux of ions and small molecules between cells. Downregulation of claudin proteins increases the paracellular permeability …

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