Takayasu Higo

Projection-specific and reversible functional blockage in the association cortex of macaque monkeys

Seiichirou Yokoo, Takayasu Higo, Florian Gérard-Mercier, Mineki Oguchi et autres

The functional manipulation techniques based on optogenetics have been widely and effectively utilized in the rodent brain. However, the applications of these techniques to the macaque cerebral cortex, particularly those to the prefrontal cortex, have been limited due to the extensive size …

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Aberrant calcium signaling by transglutaminase-mediated posttranslational modification of inositol 1,4,5-trisphosphate receptors

Kozo Hamada, Akiko Terauchi, Kyoko Nakamura, Takayasu Higo et autres

The inositol 1,4,5-trisphosphate receptor (IP3R) in the endoplasmic reticulum mediates calcium signaling that impinges on intracellular processes. IP3Rs are allosteric proteins comprising four subunits that form an ion channel activated by binding of IP3 at a distance. Defective allostery in IP3R is …

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Distributed and causal influence of frontal operculum in task control

Takayasu Higo, Rogier B. Mars, Erie D. Boorman, Ethan R. Buch et autres

It has been suggested that the frontal operculum (fO) is a key node in a network for exerting control over cognitive processes. How it exerts this influence, however, has been unclear. Here, using the complementary approaches of functional MRI and transcranial magnetic …

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Mechanism of ER Stress-Induced Brain Damage by IP3 Receptor

Takayasu Higo, Kozo Hamada, Chihiro Hisatsune, Nobuyuki Nukina et autres

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Occurrence of pre-MBT synthesis of caspase-8 mRNA and activation of caspase-8 prior to execution of SAMDC (S-adenosylmethionine decarboxylase)-induced, but not p53-induced, apoptosis in Xenopus late blastulae

Koichiro Shiokawa, Eiji Takayama, Takayasu Higo, Shinsaku Kuroyanagi et autres

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[Subtype-specific and ER lumenal environment-dependent regulation of IP3 receptor type 1 by ERp44].

Mitsuharu Hattori, Takayasu Higo, Katsuhiko Mikoshiba

Subtype-Specific and ER Lumenal Environment-Dependent Regulation of Inositol 1,4,5-Trisphosphate Receptor Type 1 by ERp44

Takayasu Higo, Mitsuharu Hattori, Takeshi Nakamura, Tohru Natsume et autres

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Involvement of caspase-9 in execution of the maternal program of apoptosis in Xenopus late blastulae overexpressed with S-adenosylmethionine decarboxylase

Eiji Takayama, Takayasu Higo, Masatake Kai, Masashi Fukasawa et autres

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Distinct Roles of Inositol 1,4,5-Trisphosphate Receptor Types 1 and 3 in Ca2+ Signaling

Mitsuharu Hattori, Akinobu Z. Suzuki, Takayasu Higo, Hiroshi Miyauchi et autres

Three subtypes of inositol 1,4,5-trisphosphate receptor (IP(3)R1, IP(3)R2, and IP(3)R3) Ca(2+) release channel share basic properties but differ in terms of regulation. To what extent they contribute to complex Ca(2+) signaling, such as Ca(2+) oscillations, remains largely unknown. Here we show that …

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Overexpression of S-adenosylmethionine decarboxylase (SAMDC) in Xeno-pus embryos activates maternal program of apoptosis as a “fail-safe” mechanism of early embryogenesis

Masatake Kai, Chikara Kaito, Hiroshi Fukamachi, Takayasu Higo et autres

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Protein 4.1N Is Required for Translocation of Inositol 1,4,5-Trisphosphate Receptor Type 1 to the Basolateral Membrane Domain in Polarized Madin-Darby Canine Kidney Cells

Songbai Zhang, Akihiro Mizutani, Chihiro Hisatsune, Takayasu Higo et autres

Protein 4.1N was identified as a binding molecule for the C-terminal cytoplasmic tail of inositol 1,4,5-trisphosphate receptor type 1 (IP(3)R1) using a yeast two-hybrid system. 4.1N and IP(3)R1 associate in both subconfluent and confluent Madin-Darby canine kidney (MDCK) cells, a well studied …

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Activation of the maternally preset program of apoptosis by microinjection of 5‐aza‐2′‐deoxycytidine and 5‐methyl‐2′‐deoxycytidine‐5′‐triphosphate in Xenopus laevis embryos

Chikara Kaito, Masatake Kai, Takayasu Higo, Eiji Takayama et autres

The present study examines the effects on embryogenesis of microinjecting Xenopus laevis fertilized eggs with 5-aza-2'-deoxycytidine (5-Aza-CdR), which induces hypomethylation of DNA, and 5-methyl-2'- deoxycytidine-5'-triphosphate (5-methyl-dCTP), which induces hypermethylation of DNA. Embryos injected with either one of these analogs cleaved normally until …

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