Mahmoud A. ElSohly

Supplemental Material for: Assessment of Claimed Vs Found Levels of Δ9-THC and CBD in Sixteen Cannabis-Derived Commercial Products

figshare admin karger, Chandrani G. Majumdar, Mona M. Geweda, Suman Chandra et autres

Introduction: The enactment of Marijuana laws in many states, coupled with the Hemp Improvement Act (the 2018 Farm Bill) has resulted in the proliferation of several cannabis-derived products. The quality of these products is suspect at best. We have previously reported on …

ch (code pays fourni par la source)

Supplemental Material for: Assessment of Claimed Vs Found Levels of Δ9-THC and CBD in Sixteen Cannabis-Derived Commercial Products

figshare admin karger, Chandrani G. Majumdar, Mona M. Geweda, Suman Chandra et autres

Introduction: The enactment of Marijuana laws in many states, coupled with the Hemp Improvement Act (the 2018 Farm Bill) has resulted in the proliferation of several cannabis-derived products. The quality of these products is suspect at best. We have previously reported on …

ch (code pays fourni par la source)

Stability of Cannabinoids in Cannabis: Plant Material, Extracts, Oil Formulations, and Isolates (CBD and Δ 9 -THC) Under Different Storage Conditions

Chandrani G. Majumdar, Mohamed M. Radwan, S. Chandra, Amira S. Wanas et autres

Background: The chemical stability of cannabinoids in Cannabis sativa plant material and formulated products is a critical factor for quality control, therapeutic efficacy, and regulatory compliance. Cannabinoids such as THC are prone to degradation over time, which is heavily influenced by storage …

us, Égypte (code pays fourni par la source)

Quantification of 14 Major and Minor Cannabinoids with Absorbance – Transmittance Excitation – Emission Matrix Spectroscopy and Machine Learning

Mostafa A. Elhendawy, Adam M. Gilmore, Mohamed M. Radwan, Elsayed A. Ibrahim et autres

Background: Cannabis plants ( Cannabis sativa ) contain a diverse group of terpenophenolic compounds known as phytocannabinoids, with 131 cannabinoids identified to date. Rapid and low-cost analytical approaches capable of quantifying both major and minor cannabinoids are increasingly important for research, quality …

Égypte, us, jp (code pays fourni par la source)

Utilizing Hot-Melt Extrusion and Spray Drying Techniques for Preparation of Liquid and Solid Cannabidiol Nano-Structured Lipid Carriers Formulations

Iman Taha, Mahmoud A. ElSohly, N.A. Mostafa, Mashan Almutairi et autres

Nanostructured lipid carriers (NLCs) have attracted considerable interest as drug delivery systems capable of enhancing the solubility and oral bioavailability of poorly water-soluble drugs. In our previous work, cannabidiol (CBD)-loaded NLCs prepared by hot homogenization demonstrated improved dissolution and oral bioavailability. In …

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Development and Validation of an HPLC–UV/PDA Method for the Determination of Cannflavins in Different Cannabis sativa Chemovars

Mostafa A. Elhendawy, Mohamed M. Radwan, El-Sayed Ibrahim, Amira S. Wanas et autres

Cannabis sativa (C. sativa) is a psychoactive plant that has been used for millennia for medicinal, recreational, and industrial purposes. The main constituents of cannabis are the cannabinoids, with other constituents including terpenes and flavonoids that contribute to its bioactivity. Among the …

Égypte, us (code pays fourni par la source)

Sex differences in the capacity of minor phytocannabinoids to attenuate nociceptive insults in HIV-1 Tat-expressing mice

Alaa N. Qrareya, Emaya Moss, Fakhri Mahdi, Mohammed Salahuddin et autres

Objecives: Approximately 80 % of people living with HIV (PLWH) develop chronic pain and preclinical studies support the involvement of the HIV-1 regulatory protein, trans-activator of transcription (Tat). Phytocannabinoids may attenuate pain in PLWH; however, these data are controversial, and the biological …

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Genetic diversity, population structure, and cannabinoid variation in feral Cannabis sativa germplasm from the United States

Ademola Aina, Jonathan P. Wenger, Emma Stanton, Chandrani G. Majumdar et autres

Cannabis sativa is one of the earliest plants to be domesticated for fiber, food and medicine. Seed from Cannabis grown for industrial purposes during the 18th through 20th centuries have escaped production and established feralized populations across the United States. To maximize …

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Genetic Diversity, Population Structure, and Cannabinoid Variation in Feral Cannabis sativa Germplasm from the United States

Ademola Aina, Jonathan P. Wenger, Emma Stanton, Chandrani G. Majumdar et autres

Abstract Cannabis sativa is one of the earliest plants to be domesticated for fiber, food and medicine. Seed from Cannabis grown for industrial purposes during the 18 th through 20 th centuries have escaped production and established feralized populations across the United …

us (code pays fourni par la source)

Characterizing Hemp-Derived Alternative Cannabis Products Available Online and at National Retail Stores

Ashley N Dowd, Harrison Elder, Meagan O. Robichaud, Austin Zamarripa et autres

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Enhancement of cannabidiol oral bioavailability through the development of nanostructured lipid carriers: In vitro and in vivo evaluation studies

Iman Taha, Mahmoud A. ElSohly, Rasha M. Elkanayati, Amira S. Wanas et autres

Cannabidiol (CBD) is a natural product isolated from the Cannabis sativa plant that was approved by the United States Food and Drug Administration (US FDA) for the treatment of resistant epilepsy. Despite its therapeutic potential, CBD's clinical application is limited by its …

us (code pays fourni par la source)

Advances in Micropropagation of Cannabis sativa L.

Hemant Lata, Suman Chandra, Ikhlas A. Khan, Mahmoud A. ElSohly

For millennia, cannabis has been utilized primarily by humans as an intoxicant, food, fiber, oil, and for medicinal and ceremonial purposes. It contains cannabinoids, a distinct class of terpenophenolic compounds. To date, more than 550 constituents have been isolated from cannabis, of …