Axel Künstner

Bacterial and fungal communities and network dynamics in Otitis media patients upon 1,8-Cineol treatment

Anke Leichtle, Axel Künstner, Zuzana Penxová, Simon Graspeuntner et autres

The present study investigated the bacterial and fungal communities and cross-domain network interactions in patients with chronic Otitis media in response to the natural monoterpene medicinal 1,8-Cineol as a promising treatment option. While the bacterial community showed modest changes with preserved core …

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Mitochondrial toxins cause widespread downregulation of pathways in X-linked dystonia-parkinsonism patient-derived neurons

Karen Grütz, Axel Künstner, Christin Krause, Letizia Santinelli et autres

The genetic mechanism underlying the neurodegenerative movement disorder X-linked dystonia-parkinsonism (XDP) involves a retrotransposon insertion within the TAF1 gene. TAF1 encodes the TATA-box binding protein-associated factor 1, the largest subunit of the basal transcription factor TFIID, which connects transcription activation to the …

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The PDI-ATF6-axis as a novel treatment target in CSF3R driven chronic neutrophilic leukemia (CNL)

Alessandra Hartke, Annika Lange, Gerin Prince, Jasmin Osius et autres

Abstract Introduction CNL is a rare myeloproliferative neoplasm (MPN) with a 5-year-survival-rate of 28 percent, and no standard of care for treatment. The majority of CNL patients harbors the membrane proximal T618I mutation in the colony-stimulating factor 3 receptor (CSF3R), which leads …

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Liquid biopsy for non-invasive molecular characterization and measurable residual disease analysis in multiple myeloma

Jan Vorwerk, Anke Schilhabel, Philipp Nakov, Sabrina Neumann et autres

Abstract Introduction: Molecular profiling and measurable residual disease (MRD) assessment have become essential in multiple myeloma (MM) decision-making. Although bone marrow (BM) aspirates are the standard for MRD measurement and molecular characterization, focal lesions and clonal heterogeneity can render BM analyses unrepresentative …

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Immune Training of the Interleukin 6 Gene in Airway Epithelial Cells is Central to Asthma Exacerbations

Lars Peter Lunding, Markus Weckmann, Ulrich M. Zissler, Constanze A. Jakwerth et autres

QUESTION: Epidemiological studies suggest that respiratory viral infections are major triggers of asthma exacerbations, and clinical studies have suggested the involvement of an increased interleukin-6 (IL-6) release. What is the pathophysiological role of IL-6 in asthma exacerbation, and which mechanisms lead to …

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Late Breaking Abstract - Immune Training of the IL6 Gene in Airway Epithelial Cells is Central to Asthma Exacerbations

Lars Peter Lunding, Markus Weckmann, Ulrich M. Zissler, Constanze A. Jakwerth et autres

Question: Epidemiological studies suggest viral infections as major triggers of asthma exacerbations and an involvement of increased IL-6 release. What is the role of IL-6 in asthma exacerbation and which mechanisms lead to enhanced IL-6 release? Methods: Exacerbations of allergic asthma in …

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Peer Review Report For: The genome sequence of the Yellow-barred Brindle, Acasis viretata (Hübner, 1799) (Lepidoptera: Geometridae) [version 1; peer review: 2 approved, 1 approved with reservations]

Axel Künstner

456P Mutational signature dynamics in gastric and esophageal cancers: A retrospective comprehensive genomic analysis

Niaz Bahadur Khan, Axel Künstner, Kim Barbara Luley, Stephanie M. J. Fliedner et autres

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Peer Review Report For: The genome sequence of the Four-spotted Footman moth, Lithosia quadra (Linnaeus, 1758) [version 1; peer review: 3 approved, 1 approved with reservations]

Axel Künstner

Immune Training of the Interleukin 6 Gene in Airway Epithelial Cells is Central to Asthma Exacerbations

Lars Peter Lunding, Markus Weckmann, Ulrich M. Zissler, Constanze A. Jakwerth et autres

Question: Epidemiological studies suggest respiratory viral infections are major triggers of asthma exacerbations, and clinical studies have suggested the involvement of an increased interleukin-6 (IL-6) release. What is the pathophysiological role of IL-6 in asthma exacerbation, and which mechanisms lead to enhanced …

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DOP030 Mucosal deficiency of mitochondria-driven humoral immunity is linked to Crohn’s Disease

Annika Raschdorf, Lorena Almeida, Philipp Solbach, Marielle Kirstein et autres

Abstract Background Secretory IgA (sIgA) is critical for the maintenance of the mucosal barrier function, preventing bacterial translocation and reducing the risk of chronic inflammation. Several decades of research have revealed a dysregulation of the B-cell compartment in inflammatory bowel disease (IBD) …

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Increase in body weight is lowered when mice received fecal microbiota transfer from donor mice treated with the AT1 receptor antagonist telmisartan

Marco L. Freschi, Axel Künstner, Gianna Huber, Ines Stölting et autres

Introduction Treatment of rodents with the AT1 blocker (ARB) telmisartan (TEL) has an anti-adipose effect. Among other mechanisms, we also have attributed the anti-adipose action to diet-independent alterations in gut microbiota. Thus, we aimed here to confirm this mechanism by using the …

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