Meritxell Alberich-Jordà

Increasing H3K9 Methylation Level Reduces the Proliferation of Leukemic Stem Cells

Barbara N. Walter, Polina Zjablovskaja, Sara Montserrat‐Vazquez, Eva Mejía-Ramírez et autres

Background/Objectives: Genetic and epigenetic alterations accumulate throughout life in hematopoietic stem and progenitor cells (HSPCs), leading to an increased risk of age-related hematological malignancies, such as acute myeloid leukemia (AML). While a few epigenetic drugs have entered clinical practice, studies focusing on …

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Replication data for "Increasing H3K9 methylation level reduces the proliferation of leukemic stem cells"

Barbara Walter, Polina Zjablovskaja, Sara Montserrat‐Vazquez, Eva Mejía-Ramírez et autres

This dataset contains the scripts and notebooks to download, process and analyse the bulk RNA-seq data described in "Increasing H3K9 methylation level reduces the proliferation of leukemic stem cells" by Walter et al., as well as the raw count matrices and the …

es, de, ru, cn (code pays fourni par la source)

Anthracyclines induce epigenetic changes in ALDH1A that promote chemoresistance in AML, revealing a potential treatment strategy co-targeting ALDH1A inhibition with hypomethylating agents

Mehak Shaikh, Francesco Leonetti, Mühübe Yazir, Céline Baier et autres

Abstract Background: Relapse/Refractory Acute Myeloid Leukemia (R/R AML) is a condition where patients do not achieve complete remission after chemotherapy and thus develop chemo-resistance. Aldehyde dehydrogenase 1A (ALDH1A) plays a critical role in leukemic cell survival by maintaining stemness, proliferation, and chemoresistance …

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Upregulation of ALDH1 as an adaptive epigenetic response to anthracyclines in acute myeloid leukemia

Francesco Leonetti, Sladjana Kosanovic, R. R. Rios, Iris Manosalva et autres

Abstract Acute myeloid leukemia (AML) is a genetically heterogeneous malignancy characterized by the clonal proliferation of undifferentiated myeloid precursors in the bone marrow. Although standard induction regimens based on anthracyclines often achieve initial remission, up to 25% of patients exhibit primary refractory …

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Germline Jak2-R1063H mutation interferes with normal hematopoietic development and increases risk of thrombosis and leukemic transformation

Veronika Zimolova, Monika Burócziová, Linda Berková, Srdjan Grusanovic et autres

The acquired JAK2-V617F mutation plays a causal role in myeloproliferative neoplasms (MPN). Weakly activating JAK2 germline variants have been associated with MPN risk, but the underlying mechanisms remain unclear. We previously identified the JAK2-R1063H germline variant, which contributes to hereditary MPN and …

cz, ru (code pays fourni par la source)

Immunotherapy for rapid bone marrow conditioning and leukemia depletion that allows efficient hematopoietic stem cell transplantation

Giada Dal Collo, Srdjan Grusanovic, Milad Rasouli, Antoinette van Hoven-Beijen et autres

Hematopoietic stem cell transplantation (HSCT) is a life-saving procedure to treat hematopoietic disorders. Current bone marrow conditioning protocols create space for healthy donor stem cells by employing irradiation and/or chemotherapy, but carry severe toxicities, resulting in significant morbidity, mortality and substantial long-term …

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Distinct transcriptional changes in hematopoietic progenitor subsets on LPS-induced emergency granulopoiesis

Sladjana Kosanovic, Karolina Vanickova, Mirko Milošević, Irina Ribeiro Bas et autres

Emergency granulopoiesis is a critical process by which hematopoietic progenitors and stem cells facilitate enhanced granulocytic production during severe infections. However, the role of distinct multipotent progenitors (MPPs) at early stages of this process remains underexplored. Here, we investigated the contribution of …

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HSCs and Tregs cooperate to preserve extramedullary hematopoiesis under chronic inflammation

Maria Kuzmina, Srdjan Grusanovic, Jiří Březina, Mirko Milošević et autres

Hematopoietic stem cells (HSCs) are localized within specialized niches of the bone marrow (BM). However, during hematological disorders or infections, the functionality of HSCs in the BM is compromised, leading to extramedullary hematopoiesis (EMH). Chronic inflammation drives EMH, yet its impact on …

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ACSL4-Associated Lipid Metabolism Is a Distinct Therapeutic Vulnerability in KMT2A-Rearranged Acute Myeloid Leukemia

Silvia Schäfer, Lola Schmitz-Hübsch, Mehak Shaikh, Silke Brilloff et autres

Background: Around 50% of acute myeloid leukemia (AML) patients harbor chromosomal aberrations, such as inversions or translocations. One of the most common chromosomal rearrangements in AML involves the lysine methyltransferase 2A (KMT2A) gene. As KMT2A-rearranged (KMT2Ar) AML is a complex and heterogeneous …

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WBP1L regulates hematopoietic stem cell function and T cell development

Imtissal Krayem, Srdjan Grusanovic, Iris Đurić, Nataliia Anatoliyivna Pavliuchenko et autres

WW domain binding protein 1-like (WBP1L), also known as outcome predictor of acute leukemia 1 (OPAL1), is a transmembrane adaptor protein, expression of which was shown to correlate with ETV6-RUNX1 translocation and favorable prognosis in childhood leukemia. It has a broad expression …

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ACSL4-Associated Lipid Metabolism is a Distinct Therapeutic Vulnerability in KMT2A-Rearranged Acute Myeloid Leukemia

Alexander Arthur Wurm, Silvia Schäfer, Lola Schmitz-Hübsch, Mehak Shaikh et autres

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Rewired glutamate metabolism diminishes cytostatic action of L-asparaginase

Kateřina Hložková, Maryna Vasylkivska, Adam Boufersaoui, Bryan P. Marzullo et autres

Tumor cells often adapt to amino acid deprivation through metabolic rewiring, compensating for the loss with alternative amino acids/substrates. We have described such a scenario in leukemic cells treated with L-asparaginase (ASNase). Clinical effect of ASNase is based on nutrient stress achieved …

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