Sandra W. Ryeom

Supplemental Table 2 from Stool Protein Mass Spectrometry Identifies Biomarkers for Early Detection of Diffuse-type Gastric Cancer

Chi-Lee C. Ho, Michael B. Gilbert, Guillaume Urtecho, Hyoungjoo Lee et autres

Supplemental Table 2 describes the biopsy information of patient derived organoid cell lines.

Supplemental Figure 2 from Stool Protein Mass Spectrometry Identifies Biomarkers for Early Detection of Diffuse-type Gastric Cancer

Chi-Lee C. Ho, Michael B. Gilbert, Guillaume Urtecho, Hyoungjoo Lee et autres

Supplemental Figure 2 contains stomach immunofluorescence images for Figure 3B.

Supplemental Figure 4 from Stool Protein Mass Spectrometry Identifies Biomarkers for Early Detection of Diffuse-type Gastric Cancer

Chi-Lee C. Ho, Michael B. Gilbert, Guillaume Urtecho, Hyoungjoo Lee et autres

Supplemental Figure 4 contains heat maps of stool proteins between various stool donor groups and emphasizes the differential abundance of protein profiles based on donor status.

Supplemental Figure 3 from Stool Protein Mass Spectrometry Identifies Biomarkers for Early Detection of Diffuse-type Gastric Cancer

Chi-Lee C. Ho, Michael B. Gilbert, Guillaume Urtecho, Hyoungjoo Lee et autres

Supplemental Figure 3 shows the progression of disease between 4and 8 week old TCON mice and the amount of ACTN4 and DPP4 in stomach tissue.

Supplemental Figure 1 from Stool Protein Mass Spectrometry Identifies Biomarkers for Early Detection of Diffuse-type Gastric Cancer

Chi-Lee C. Ho, Michael B. Gilbert, Guillaume Urtecho, Hyoungjoo Lee et autres

Supplemental Figure 1 shows the effect using different lysis buffers has on protein identification in stool protein mass spectrometry.

Supplemental Figure 5 from Stool Protein Mass Spectrometry Identifies Biomarkers for Early Detection of Diffuse-type Gastric Cancer

Chi-Lee C. Ho, Michael B. Gilbert, Guillaume Urtecho, Hyoungjoo Lee et autres

Supplemental Figure 5 shows the effect of S1P pathway lipids on GC cell lines without the presence of C6-U-Cer inhibition.

Supplemental Table 1 from Stool Protein Mass Spectrometry Identifies Biomarkers for Early Detection of Diffuse-type Gastric Cancer

Chi-Lee C. Ho, Michael B. Gilbert, Guillaume Urtecho, Hyoungjoo Lee et autres

Supplemental Table 1 lists the age and sex of stool donors.

Editorial Expression of Concern: Nociceptive neurons promote gastric tumour progression via a CGRP–RAMP1 axis

Xiaofei Zhi, Feijing Wu, Jin Qian, Yosuke Ochiai et autres

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Single-nucleus multiome sequencing identifies candidate regulators of mouse gastric epithelial homeostasis

Maithê Rocha Monteiro de Barros, Katharina Bosch, Salima Soualhi, Shirin Issa Bhaloo et autres

Background & Aims: Gastric epithelial cells maintain homeostasis through dynamic self-renewal mechanisms involving stem and progenitor cells; however, identifying them has been challenging. This study aims to identify stem cells of healthy gastric epithelium and cell type-specific regulators defining gastric epithelial homeostasis …

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Abstract 7479: A CCL20-high chemokine program defines a CCR6+ immune-myeloid niche in gastric cancer

Kurtay Ozuner, Jaewon Kim, Sandra W. Ryeom

Abstract Introduction: Gastric cancer remains one of the leading causes of cancer mortality worldwide and is characterized by an aggressive clinical course and a profoundly immunosuppressive tumor microenvironment with limited therapeutic options. Chemokine signaling has emerged as an important regulator of gastric …

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Abstract 6227: Cancer-associated enteric glial cell abundance as a prognostic marker in gastric cancer revealed by single-cell analysis

Carolyn R. DePinho, Jianming Zeng, Xiling Shen, Sandra W. Ryeom

Abstract Enteric glial cells (EGCs), essential regulators of gastrointestinal barrier function, immune responses, and neuro-epithelial homeostasis, remain largely unexplored in the context of gastric cancer (GC). EGCs are a specialized population of peripheral neuroglia that, along with enteric neurons, make up the …

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Lung endothelial niche signaling governs self-renewal and fate transitions of human alveolar stem cells

Bang-Jin Kim, Dasom Hwang, Jimyung Park, Sung Joo Jang et autres

Abstract Chronic lung diseases such as pulmonary fibrosis are characterized by the irreversible loss of alveolar type 1 (AT1) cells, yet the mechanisms governing human alveolar stem cell self-renewal and differentiation remain poorly defined. Here, we identify a lung endothelial niche that …

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