2026
conference-abstract
OpenAlex
Lawrence W. Wu, Jimyung Park, Sung Joo Jang, Ryan H. Moy
e15205 Background: Mucinous carcinoma (MC) is a rare, aggressive histological subtype of adenocarcinoma that is associated with poor prognosis and peritoneal spread. Molecular features of MC across gastrointestinal (GI) primary sites remain incompletely defined. Utilizing the American Association for Cancer Research (AACR) …
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2026
conference-abstract
OpenAlex
Lawrence W. Wu, Jimyung Park, Sung Joo Jang, Ryan H. Moy
2650 Background: POLE and POLD1 encode key enzymes for DNA proofreading. Oncogenic alterations in POLE and POLD1 associated with defective proofreading can lead to tumor hypermutation and increased sensitivity to immune checkpoint inhibition. Prior studies have identified enrichment of POLE and POLD1 …
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Accès ouvert
2026
preprint
OpenAlex
Bang-Jin Kim, Dasom Hwang, Jimyung Park, Sung Joo Jang et autres
Abstract Chronic lung diseases such as pulmonary fibrosis are characterized by the irreversible loss of alveolar type 1 (AT1) cells, yet the mechanisms governing human alveolar stem cell self-renewal and differentiation remain poorly defined. Here, we identify a lung endothelial niche that …
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Accès ouvert
2026
conference-abstract
OpenAlex
Lawrence Wen Wu, Jimyung Park, Sung Joo Jang, Ryan H. Moy
846 Background: There is an alarming rise in early-onset (EO) gastrointestinal (GI) cancers, which may have distinct genomic profiles compared with later-onset (LO) cases. OncoKB is a validated database that provides evidence-based annotation of genomic alterations with therapeutic relevance. Utilizing the American …
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Accès ouvert
2025
article
OpenAlex
Lawrence Wen Wu, Sachin Kumar Deshmukh, Sharon K. Wu, Joanne Xiu et autres
Using a large real-world database with matched genomic and transcriptomic data, we characterized clinical and molecular differences between patients with early-onset esophagogastric cancer (EOEGC; <50 years), intermediate-onset esophagogastric cancer (IOEGC; 50-65 years), and average-onset esophagogastric cancer (AOEGC; >65 years). We analyzed clinicopathologic, …
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2025
conference-abstract
OpenAlex
Sung Joo Jang, Lawrence Wen Wu, Sho Hangai, Cameron Shapiro et autres
Abstract Background: Cyclin E (CCNE1) is amplified in multiple cancers including approximately 10% of esophagogastric cancers and 20% of ovarian cancers. CCNE1 amplification leads to DNA replication stress and chromosomal instability. Prior studies have found that CCNE1 amplification in gastric cancer is …
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2025
conference-abstract
OpenAlex
Lawrence Wen Wu, Sung Joo Jang, Jimyung Park, Cameron Shapiro et autres
Abstract Introduction: Diffuse-type gastric cancer (DGC) accounts for one third of gastric cancers and is associated with poor differentiation, discohesive growth, chemoresistance, and worse survival compared to intestinal-type tumors. DGC is typically genomically stable, and there are no approved DGC-targeted therapies. Recent …
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Accès ouvert
2024
article
OpenAlex
Lawrence Wen Wu, Sung Joo Jang, Cameron Shapiro, Ladan Fazlollahi et autres
Diffuse-type gastric cancer (DGC) accounts for approximately one-third of gastric cancer diagnoses but is a more clinically aggressive disease with peritoneal metastases and inferior survival compared with intestinal-type gastric cancer (IGC). The understanding of the pathogenesis of DGC has been relatively limited …
us
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