David R. Fortin

Adult Patient with Primary Intracranial Sarcoma DICER1 Mutated: Therapy Leading to Prolonged Survival and Local Control

Christina Toma, David R. Fortin, Sébastien Chénier, Marie-Christine Guiot et autres

ca (code pays fourni par la source)

NCOG-50. Correlation of tract-based diffusion metrics with visuospatial function following glioma surgery

Keiss Douri, François Rheault, Sabrina D’Amour, Maxime Descoteaux et autres

Abstract Gliomas are diffusely infiltrative tumors without clear margins. While greater extent of resection is associated with improved overall survival, it must be balanced against the risk of iatrogenic neurological deficits which may compromise quality of life. This balance between extent of …

ca (code pays fourni par la source)

P2.06.70 Concurrent Tissue and ctDNA-Based Genomic Profiling in Advanced Lung Cancer: A Prospective, Single-Institution Study

Sunil Verma, E. Holjak, Tia Brasoveanu, Sabbir Khan et autres

ca, gb (code pays fourni par la source)

Towards fair decentralized benchmarking of healthcare AI algorithms with the Federated Tumor Segmentation (FeTS) challenge

Maximilian Zenk, Ujjwal Baid, Sarthak Pati, Akis Linardos et autres

Computational competitions are the standard for benchmarking medical image analysis algorithms, but they typically use small curated test datasets acquired at a few centers, leaving a gap to the reality of diverse multicentric patient data. To this end, the Federated Tumor Segmentation …

de, us, es, ca, hk, cn, fi, pk, fr, ch, au, tr, in, gb, ie, sg (code pays fourni par la source)

Detailed characterization of partial tumor resection in the Syngeneic Fischer/F98 Glioma Model

Laurence Déry, Gabriel Charest, Brigitte Guérin, David R. Fortin

BACKGROUND: Preclinical models of brain tumors play a fundamental role in understanding tumor biology and deploying anti-tumor strategies. However, preclinical studies evaluate their potential therapy in tumor model without prior resection. Nevertheless, maximal safe resection, the first step in the clinical treatment …

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Optimization of Intra-Arterial Administration of Chemotherapeutic Agents for Glioblastoma in the F98-Fischer Glioma-Bearing Rat Model

Juliette Latulippe, Laurent-Olivier Roy, Fernand Gobeil, David R. Fortin

Glioblastoma (GBM) is a difficult disease to treat for different reasons, with the blood-brain barrier (BBB) preventing therapeutic drugs from reaching the tumor being one major hurdle. The median overall survival is only 14.6 months after the standard first line of treatment. …

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Microneedle arrays for brain drug delivery: the potential of additive manufacturing

Mahmood Razzaghi, Sanaz Soleymani Eil Bakhtiari, Gabriel Charest, David R. Fortin et autres

For a long time, the treatment of brain diseases has been a significant challenge. Drug delivery to the brain has recently become one of the most challenging problems for patients with severe forms of central nervous system diseases. The blood–brain barrier (BBB) …

ca, gb, us (code pays fourni par la source)

Safety of Cerebral Intra-Arterial Chemotherapy for the Treatment of Malignant Brain Tumours

G. Gahide, Jean-François Vendrell, Karine Massicotte-Tisluck, Samuel Caux et autres

Background: Cerebral intra-arterial chemotherapy (CIAC) has been demonstrated to achieve tumoricidal concentrations in cerebral tumour cells that are otherwise unachievable due to the presence of the blood–brain barrier. In this study, we sought to analyze the safety of CIAC in a cohort …

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Kinin agonists as a means to increase blood–brain barrier permeability of drugs

Juliette Latulippe, David R. Fortin, Fernand Jr Gobeil

ca (code pays fourni par la source)

List of contributors

François Alhenc‐Gelas, Ronaldo C. Araújo, M. Bader, Menakshi Bhat et autres

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Clinical research framework proposal for ketogenic metabolic therapy in glioblastoma

Tomás Duraj, Miriam Kalamian, Giulio Zuccoli, Joseph C. Maroon et autres

Glioblastoma (GBM) is the most aggressive primary brain tumor in adults, with a universally lethal prognosis despite maximal standard therapies. Here, we present a consensus treatment protocol based on the metabolic requirements of GBM cells for the two major fermentable fuels: glucose …

us, de, gb, at, nz, br, ca, es, ve, Afrique du Sud, cn, it, tr, au, Égypte, jp, gr, in (code pays fourni par la source)

EXTH-29. EVALUATION OF THE ANTITUMOR EFFECT OF A CHEMOTHERAPY-LOADED DEVICE FOR THE TREATMENT OF PRIMARY BRAIN TUMORS

Laurence Déry, Gabriel Charest, Brigitte Guérin, Mohsen Akbari et autres

Abstract Glioblastoma (GBM) is the most frequent and aggressive primary brain tumor in adults. Tumor recurrence is therefore inevitable, and median survival is just over 14 months. Currently available treatments are inadequate and do not provide optimal tumor control. We believe that …

ca (code pays fourni par la source)