Shakchhi Joshi

Glutamine-Dependent Biosynthetic Pathways Fuel Autoreactive T and B Cells in Foxp3 Deficiency-mediated Disease 2259241

Mohammad Adeel Zafar, Charlotte Nicole Hill Machado, Jyotirmaya Behera, Yuelin Zhong et autres

Foxp3 deficiency causes a profound loss of immune tolerance, unleashing autoreactive T and B cells, lymphoproliferation, cytokine-driven inflammation, and autoantibody production. This autoimmune pathology is fueled by increased glutamine usage, but it remains unresolved whether glutamine is necessary to produce energy or …

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Figure S5 from Age-Associated Contraction of Tumor-Specific T Cells Impairs Antitumor Immunity

Peter Georgiev, SeongJun Han, Amy Y. Huang, Thao H. Nguyen et autres

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Figure S1 from Age-Associated Contraction of Tumor-Specific T Cells Impairs Antitumor Immunity

Peter Georgiev, SeongJun Han, Amy Y. Huang, Thao H. Nguyen et autres

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Figure S7 from Age-Associated Contraction of Tumor-Specific T Cells Impairs Antitumor Immunity

Peter Georgiev, SeongJun Han, Amy Y. Huang, Thao H. Nguyen et autres

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Figure S4 from Age-Associated Contraction of Tumor-Specific T Cells Impairs Antitumor Immunity

Peter Georgiev, SeongJun Han, Amy Y. Huang, Thao H. Nguyen et autres

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Figure S2 from Age-Associated Contraction of Tumor-Specific T Cells Impairs Antitumor Immunity

Peter Georgiev, SeongJun Han, Amy Y. Huang, Thao H. Nguyen et autres

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Figure S6 from Age-Associated Contraction of Tumor-Specific T Cells Impairs Antitumor Immunity

Peter Georgiev, SeongJun Han, Amy Y. Huang, Thao H. Nguyen et autres

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Figure S3 from Age-Associated Contraction of Tumor-Specific T Cells Impairs Antitumor Immunity

Peter Georgiev, SeongJun Han, Amy Y. Huang, Thao H. Nguyen et autres

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Figure S8 from Age-Associated Contraction of Tumor-Specific T Cells Impairs Antitumor Immunity

Peter Georgiev, SeongJun Han, Amy Y. Huang, Thao H. Nguyen et autres

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Epigenetic and oncogenic inhibitors converge to drive a metabolic catastrophe in castration-resistant prostate cancer

Rhea Sahu, Miriam Enos, Swastika Sharma, Amy E. Schade et autres

Men with advanced prostate cancer are typically treated with androgen deprivation therapy, but most ultimately develop resistance and incurable disease (e.g., castration-resistant prostate cancer, CRPC). The majority of CRPCs overexpress the epigenetic enzyme EZH2 and harbor alterations in the PI3K pathway, providing …

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Abstract LB194: SIRT5 induces a metabolic switch to fuel nucleotide pools and chemoresistance in triple-negative breast cancer

Zuen Ren, Tiziano Bernasocchi, Kiran Kurmi, Chenxu Guo et autres

Abstract Chemoresistance is a primary cause of relapse and mortality in triple-negative breast cancer (TNBC). To reveal the metabolic characteristics that contribute to de novo chemoresistance in human TNBC, we analyzed primary tumor biopsies prior to preoperative chemotherapy, employing quantitative mass spectrometry-based …

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A SIRT5-induced metabolic switch underlies chemoresistance and ATR checkpoint dependence in triple-negative breast cancer

Zuen Ren, Tiziano Bernasocchi, Kiran Kurmi, Chenxu Guo et autres

Abstract Chemoresistance is the leading cause of poor prognosis in triple-negative breast cancer (TNBC), yet the underlying mechanisms remain unknown. To reveal metabolic drivers of de novo chemoresistance in TNBC, we analyzed pretreatment primary tumor biopsies, employing quantitative proteomics and metabolomics. Chemoresistant …

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