Yonghe Liao

Renin–angiotensin system inhibitor use and survival outcomes in lung cancer: a systematic review and meta-analysis

Yongqian Liao, Jinhai Shen, Yonghe Liao, Yuxuan Lin et autres

Background Renin-angiotensin system inhibitors (RASi) have been associated with favorable survival outcomes across various cancers, but their association with survival in lung cancer remains uncertain. We conducted a systematic review and meta-analysis to evaluate the association between RASi use and survival outcomes …

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Prognostic value of baseline circulating tumor DNA levels in metastatic castration-resistant prostate cancer: a systematic review and meta-analysis

Yonghe Liao, Yuxuan Lin, Bo Luo, Jinhai Shen

Background: Metastatic castration-resistant prostate cancer (mCRPC) remains a clinically aggressive and lethal disease. Circulating tumor DNA (ctDNA), as a minimally invasive biomarker, has shown prognostic utility in several solid tumors. However, its clinical relevance in mCRPC has not been comprehensively elucidated. Methods: …

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A hepatocyte mitochondria targeting and carboxylesterase-activated probe for detection and surgical guidance of hepatocellular carcinoma resection

Yonghe Liao, Shuixiu Chen, Dan Mo, Xiaomei Chen et autres

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Acetaminophen use and prognosis in cancer patients treated with immune checkpoint inhibitors: evidence from a meta-analysis

Yuxuan Lin, Yonghe Liao, Jinhai Shen

Background: Emerging studies have investigated the association between acetaminophen (APAP) use and clinical outcomes in cancer patients receiving immune checkpoint inhibitors (ICIs), but their findings remain inconsistent. This meta-analysis aims to systematically synthesize available evidence to clarify this relationship and provide evidence-based …

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Addition of immunotherapy to perioperative chemotherapy for resectable gastric and gastroesophageal junction cancer: a meta-analysis of phase 2/3 trials

Yuxuan Lin, Yonghe Liao, Jinhai Shen

Background: The integration of immune checkpoint inhibitors (ICIs) with perioperative chemotherapy (CT) has become a major focus of clinical research in resectable gastric or gastroesophageal junction (G/GEJ) cancer. Recent phase 2 and 3 trials have reported disparate outcomes, generating considerable debate. To …

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First-line immune checkpoint inhibitors plus targeted therapy versus sorafenib or lenvatinib monotherapy for unresectable or advanced hepatocellular carcinoma: a meta-analysis of phase 3 trials

Yuxuan Lin, Yonghe Liao, Bo Luo, Jinhai Shen

Background Immune checkpoint inhibitor (ICI) and targeted therapy (TT) combinations have emerged as promising first-line treatments for unresectable or advanced hepatocellular carcinoma (u/aHCC), leveraging synergistic anti-tumor effects. However, the comparative efficacy and safety of ICI-TT regimens versus sorafenib or lenvatinib (S/L) monotherapy …

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Strategic Design of Triple GLP-1R/GCGR/GIPR Agonists with Varied Receptor Potency: Achieving Comparable Glycemic and Weight Reduction Effects

Shuang Wang, Yun Liu, Zhiming Yan, Xianxian Huang et autres

Triple activation of the glucagon-like peptide 1 receptor (GLP-1R), the GIP receptor (GIPR), and the glucagon receptor (GCGR) is an innovative strategy for treating obesity and diabetes. We report the rational design of triple GLP-1R/GCGR/GIPR agonists, featuring potent GLP-1R and GCGR activity …

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A dual-locked hepatic-targeting fluorescent probe for hepatocellular carcinoma imaging with HClO and β-galactosidase activation

Yonghe Liao, Weilin Pang, Yanchun Yang, Mingyue Lu et autres

Hepatocellular carcinoma (HCC) is one of the most common types of cancers. Identifying and validating specific and robust cancer biomarkers is paramount for the early screening, timely diagnosis, and accurate prognosis of a cancer. Overexpression of hypochlorous acid (HClO) and β -galactosidase …

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First-line immune checkpoint inhibitors with chemotherapy in advanced gastric and gastroesophageal junction adenocarcinoma: a meta-analysis of phase 3 trials

Yuxuan Lin, Yonghe Liao, Jinhai Shen

Background: The integration of immune checkpoint inhibitors (ICIs) with chemotherapy (CT) regimens has become a critical focus of clinical investigation in the management of advanced gastric and gastroesophageal junction (G/GEJ) adenocarcinoma over the past several years. Recent phase 3 trials have yielded …

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Elevated circulating IL-8 correlates with poor prognosis in urological cancers: a meta-analysis and bioinformatic validation

Yuxuan Lin, Yonghe Liao, Mengqian Huang, Jinhai Shen

BACKGROUND: Interleukin-8 (IL-8) is a key cytokine that has been implicated in multiple aspects of cancer progression and therapeutic resistance. Elevated levels of circulating IL-8 (cIL-8) have been implicated in adverse clinical outcomes among patients with urological cancers. However, definitive evidence consolidating …

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Angiotensin system inhibitors improve survival in patients undergoing pancreatic cancer resection: a meta-analysis of real-world evidence

Yuxuan Lin, Yonghe Liao, Jinhai Shen

BACKGROUND: The role of angiotensin system inhibitors (ASIs) in modifying the prognosis for patients undergoing pancreatic cancer resection is not yet definitively established. This meta-analysis endeavors to consolidate existing real-world data to provide a robust, evidence-based assessment of their impact on clinical …

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Concomitant Statin Use and Survival in Patients With Cancer on Immune Checkpoint Inhibitors: A Meta-Analysis

Yonghe Liao, Yuxuan Lin, Xinqi Ye, Jinhai Shen

PURPOSE: The prognostic significance of concomitant statin use in cancer treatment with immune checkpoint inhibitors (ICIs) remains a subject of ongoing investigation. This study aims to clarify the prognostic value of statin use in this patient population and to provide a robust, …

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