Jaco Hagoort

Vascular Neuroembryology: The Genesis of the Intracranial Arterial System and the Circle of Willis

Karl Jacobs, Chelsey Marjana Linnenbank, René van den Berg, Geerling Langenbach et autres

Cerebrovascular disorders, encompassing conditions such as stroke, aneurysms, and arteriovenous malformations, are often associated with developmental malformations of the intracranial arterial system, including the circle of Willis. The circle of Willis plays a crucial role in establishing a collateral vascular network essential …

nl, us, se (code pays fourni par la source)

Timing of Secondary Palate Fusion in Human Embryos and Fetuses

Puck Pauline Mulder, Jess Johanna Peters, Yousif Dawood, Karl Jacobs et autres

INTRODUCTION: The human face develops through a complex sequence of growth and fusion events involving multiple pharyngeal arch derivatives. Disruptions in these processes can result in congenital anomalies such as cleft lip and/or palate (CL/P), which occur in approximately 1.6 per 1000 …

nl (code pays fourni par la source)

Hierarchical Phase-Contrast Tomography Imaging: Applicability in biomedical research

Daniël Docter, Joseph Brunet, Vaishnavi Sabarigirivasan, Giel Lemmens et autres

Abstract Objectives Hierarchical Phase-Contrast Tomography (HiP-CT) enables non-destructive, multi-scale imaging of whole human organs. We describe how HiP-CT is utilized for biomedical research within the Human Organ Atlas Hub through three case studies: mapping the enteric nervous system (ENS) of the human …

nl, fr, gb, de, be, dk, in (code pays fourni par la source)

Evaluating micro-computed tomography for investigation of the pediatric hyoid-larynx complex

Alexia Van Goethem, Daniël Docter, Jaco Hagoort, Yousif Dawood et autres

BACKGROUND: Conventional CT imaging has limitations in detecting subtle fractures or soft tissue hemorrhages of the pediatric hyoid-larynx complex due to its largely unossified, cartilaginous structure, creating a diagnostic gap in forensic investigations. OBJECTIVE: To explore the feasibility of micro-computed tomography (micro-CT) …

nl, be (code pays fourni par la source)

The value of micro-CT imaging in the forensic evaluation of neck trauma

Gary Timmerman, Alexia Van Goethem, Daniël Docter, Jaco Hagoort et autres

AIM: Forensic examination of the hyoid-larynx complex (HLC) is crucial in diagnosing (inflicted) neck trauma. Clinical Total-Body CT (TBCT) scans of the (non-)calcified HLC lack sensitivity for fracture detection. Micro-computed tomography (micro-CT) is an upcoming imaging modality capable of scanning samples at …

nl, be (code pays fourni par la source)

Advancing Understanding of Anorectal Malformations Through Microfocus Computed Tomography Imaging of Resected Material

Daniël Docter, Bernadette S. de Bakker, Jaco Hagoort, Joris J. T. H. Roelofs et autres

Background and Aims: Patients born with anorectal malformations (ARMs) might experience constipation and fecal incontinence. During ARM surgery (anterior and posterior sagittal anorectoplasty procedure), the distal part of the bowel (fistula) is usually resected. Microfocus computed tomography (micro-CT) imaging, capable of imaging …

nl (code pays fourni par la source)

Imaging the development of the human craniofacial arterial system – an experimental study

Karl Jacobs, G.E.J. Langenbach, Daniël Docter, P A M Cordewener et autres

BACKGROUND: The process of vascular development is essential for shaping complex craniofacial structures. Investigating the interplay between vascular development and orofacial morphogenesis holds critical importance in clinical practice and contributes to advancing our comprehension of (vascular) developmental biology. New insights into specific …

nl (code pays fourni par la source)

Micro‐ CT Imaging of Tracheal Development in Down Syndrome and Non‐Down Syndrome Fetuses

M. Matthijs Fockens, Yousif Dawood, Mika J. Zwart, Daniël Docter et autres

OBJECTIVES: Down syndrome (DS) is associated with airway abnormalities including a narrowed trachea. It is uncertain whether this narrowed trachea in DS is a consequence of deviant fetal development or an acquired disorder following endotracheal intubation after birth. This study aimed to …

nl (code pays fourni par la source)

Scaling up contrast-enhanced micro-CT imaging: Optimizing contrast and acquisition for large ex-vivo human samples

Daniël Docter, Melanie GMM Timmerman, Yousif Dawood, Jaco Hagoort et autres

A C T Microfocus Computed Tomography (Micro-CT) is a novel method for non-destructive 3D imaging of samples, reaching microscale resolutions.While initially prominent in material sciences for small samples, micro-CT now gains significance in biological and medical studies.Here we present our utilization of …

nl, be (code pays fourni par la source)

Scaling Up Contrast-Enhanced Micro-Ct Imaging: Optimizing Contrast and Acquisition for Large Ex-Vivo Human Samples

Daniël Docter, Melanie Greta Maria Timmerman, Yousif Dawood, Jaco Hagoort et autres

us, nl, be (code pays fourni par la source)

Microfocus computed tomography for fetal postmortem imaging: an overview

Daniël Docter, Yousif Dawood, Karl Jacobs, Jaco Hagoort et autres

Over the last few years, fetal postmortem microfocus computed tomography (micro-CT) imaging has increased in popularity for both diagnostic and research purposes. Micro-CT imaging could be a substitute for autopsy, particularly in very early gestation fetuses for whom autopsy can be technically …

nl, gb (code pays fourni par la source)

The developmental impacts of natural selection on human pelvic morphology

Mariel Young, Daniel Richard, Mark Grabowski, Benjamin M. Auerbach et autres

Evolutionary responses to selection for bipedalism and childbirth have shaped the human pelvis, a structure that differs substantially from that in apes. Morphology related to these factors is present by birth, yet the developmental-genetic mechanisms governing pelvic shape remain largely unknown. Here, …

us, no, gb, nl, ca (code pays fourni par la source)