Josephine Mendoza

Transcriptomic profile of adverse neurodevelopmental outcomes after neonatal encephalopathy

Paolo Montaldo, Aubrey J. Cunnington, Vânia Oliveira, Ravi Shankar Swamy et autres

A rapid and early diagnostic test to identify the encephalopathic babies at risk of adverse outcome may accelerate the development of neuroprotectants. We examined if a whole blood transcriptomic signature measured soon after birth, predicts adverse neurodevelopmental outcome eighteen months after neonatal …

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White matter injury after neonatal encephalopathy is associated with thalamic metabolite perturbations

Paolo Montaldo, Phoebe Ivain, Peter Lally, Paul Bassett et autres

BACKGROUND: Although thalamic magnetic resonance (MR) spectroscopy (MRS) accurately predicts adverse outcomes after neonatal encephalopathy, its utility in infants without MR visible deep brain nuclei injury is not known. We examined thalamic MRS metabolite perturbations in encephalopathic infants with white matter (WM) …

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Early Postnatal Heart Rate Variability in Healthy Newborn Infants

Vânia Oliveira, Wilhelm von Rosenberg, Paolo Montaldo, Tricia Adjei et autres

Background Despite the increasing interest in fetal and neonatal heart rate variability analysis and its potential use as a tool for early disease stratification, no studies have previously described the normal trends of heart rate variability in healthy babies during the first …

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Pre-emptive opioid sedation during therapeutic hypothermia

Paolo Montaldo, Anuj Vakharia, Phoebe Ivain, Josephine Mendoza et autres

Although none of the major cooling trials mandated routine pre-emptive sedation, anecdotal evidence suggests that opioids are widely used during neonatal cooling therapy. We examined the current practice of pre-emptive opioid sedation during cooling therapy in the UK neonatal units and to …

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Preemptive Morphine During Therapeutic Hypothermia After Neonatal Encephalopathy: A Secondary Analysis

Natasha Liow, Paolo Montaldo, Peter Lally, Justinas Teišerskas et autres

Although therapeutic hypothermia (TH) improves outcomes after neonatal encephalopathy (NE), the safety and efficacy of preemptive opioid sedation during cooling therapy is unclear. We performed a secondary analysis of the data from a large multicountry prospective observational study (Magnetic Resonance Biomarkers in …

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Magnetic resonance spectroscopy assessment of brain injury after moderate hypothermia in neonatal encephalopathy: a prospective multicentre cohort study

Peter Lally, Paolo Montaldo, Vânia Oliveira, Aung Soe et autres

BACKGROUND: In neonatal encephalopathy, the clinical manifestations of injury can only be reliably assessed several years after an intervention, complicating early prognostication and rendering trials of promising neuroprotectants slow and expensive. We aimed to determine the accuracy of thalamic proton magnetic resonance …

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Therapeutic hypothermia initiated within 6 hours of birth is associated with reduced brain injury on MR biomarkers in mild hypoxic-ischaemic encephalopathy: a non-randomised cohort study

Paolo Montaldo, Peter Lally, Vânia Oliveira, Ravi Shankar Swamy et autres

OBJECTIVE: To examine the effect of therapeutic hypothermia on MR biomarkers and neurodevelopmental outcomes in babies with mild hypoxic-ischaemic encephalopathy (HIE). DESIGN: Non-randomised cohort study. SETTING: Eight tertiary neonatal units in the UK and the USA. PATIENTS: 47 babies with mild HIE …

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Whole Blood Gene Expression Reveals Specific Transcriptome Changes in Neonatal Encephalopathy

Paolo Montaldo, Myrsini Kaforou, Gabriele Pollara, David Hervás et autres

BACKGROUND: Variable responses to hypothermic neuroprotection are related to the clinical heterogeneity of encephalopathic babies; hence better disease stratification may facilitate the development of individualized neuroprotective therapies. OBJECTIVES: We examined if whole blood gene expression analysis can identify specific transcriptome profiles in …

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Hypothermia for encephalopathy in low-income and middle-income countries: feasibility of whole-body cooling using a low-cost servo-controlled device

Vânia Oliveira, J Kumutha, Narayanan Eswar, Jagadish Somanna et autres

Although therapeutic hypothermia (TH) is the standard of care for hypoxic ischaemic encephalopathy in high-income countries, the safety and efficacy of this therapy in low-income and middle-income countries (LMICs) is unknown. We aimed to describe the feasibility of TH using a low-cost …

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Therapeutic hypothermia in mild neonatal encephalopathy: a national survey of practice in the UK

Vânia Oliveira, Dev Prya Singhvi, Paolo Montaldo, Peter Lally et autres

Although major cooling trials (and subsequent guidelines) excluded babies with mild encephalopathy, anecdotal evidence suggests that cooling is often offered to these infants. We report a national survey on current cooling practices for babies with mild encephalopathy in the UK. From 74 …

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Maternal sedation during scheduled versus unscheduled cesarean delivery: implications for skin-to-skin contact

Joseph Bradley Bavaro, Josephine Mendoza, Robert J. McCarthy, Paloma Toledo et autres

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