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2026
article
OpenAlex
Sezgi Canaslan, Matthias Schmitz, Fabian Maass, Péter Hermann et autres
Detection of alpha-synuclein (α-Syn) seeding activity in tear fluid (TF) offers a promising non-invasive biomarker for Parkinson's disease (PD). α-Syn seeding amplification assay (αSynSAA) detected seeding activity in 67% of PD-TF, while non-synucleinopathy samples remained negative. Electron microscopy of seeding-positive end products …
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2026
preprint
OpenAlex
Laura Tzeplaeff, X. Liu, Clara Meijs, Lucas Caldi Gomes et autres
de, us, au, fr
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2025
preprint
OpenAlex
Sezgi Canaslan, Matthias Schmitz, Fabian Maass, Péter Hermann et autres
Abstract Detection of alpha-synuclein seeding activity in tear fluid (TF) might provide a promising non-invasive biomarker for Parkinson’s disease (PD) diagnosis. In this study, we applied the alpha-synuclein seeding amplification assay (aSynSAA) to detect misfolded alpha-synuclein (aSyn) aggregation in TF from PD …
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2023
article
OpenAlex
Shuyu Zhang, Karina Dauer, Timo Strohäker, Lars Tatenhorst et autres
Parkinson's disease (PD), multiple system atrophy (MSA), and dementia with Lewy bodies (DLB) are neurodegenerative disorders with alpha-synuclein (α-syn) aggregation pathology. Different strains of α-syn with unique properties are suggested to cause distinct clinical and pathological manifestations resulting in PD, MSA, or …
de, kr, au
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2005
article
OpenAlex
Kathleen C. Barnes, Audrey Virginia Grant, D.N. Baltadzhieva, Shuyu Zhang et autres
us, nl
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