Nishtha Tanwar

Combined (SoliQ) molecular profiling using whole exome sequencing in advanced HNSCC at baseline: Lessons learned for prognostication and treatment planning.

Vidya Veldore, Vanita Noronha, Vijay Patil, Nishtha Tanwar et autres

e18025 Background: HNSCC imparts rising incidence and mortality rate worldwide, due to lack of information regarding spatial and temporal heterogeneity of the tumors. Nearly 50 to 60% of advanced node positive HNSCC are known to develop platinum resistance during the course of …

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The Indian cancer genome landscape: Pathogenic alterations and emerging therapeutic targets.

Satya Prakash Khuntia, Nilesh Mukherjee, J Vyomesh, Jinumary John et autres

e15094 Background: Comprehensive genomic profiling (CGP) is essential for identifying actionable and prognostic biomarkers in oncology practice. This study investigates oncogenic alterations, key driver mutations, and co-mutation patterns in Indian cancer patients. By targeting hallmark pathways driving disease progression, it highlights the …

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Novel Gene expression-based Risk Stratification tool predicts recurrence in Non-muscle invasive Bladder cancer

N Srivatsa, Hari PS, P. Patel Rahul, Lista Paul et autres

BACKGROUND: Bladder cancer represents a heterogeneous disease with distinct clinical challenges. Non-muscle invasive bladder cancer (NMIBC) typically presents as indolent and slow-growing, yet a critical clinical challenge remains: identifying which patients will progress to muscle-invasive disease requiring radical interventions. Early detection of …

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Novel Gene expression-based Risk Stratification tool predicts recurrence in Non-muscle invasive Bladder cancer

N Srivatsa, Parameswaran Hari, P. Patel Rahul, Lista Paul et autres

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Deep Diving Into the Fusion Across Cancer Types in the Indian Population From Formalin-Fixed Paraffin-Embedded RNA-Exome Data: A Road to Discovering Novel Rearrangements With Clinical Relevance

Satya Prakash Khuntia, Nilesh Mukherjee, Vyomesh Javle, Nishtha Tanwar et autres

PURPOSE Gene fusions are critical oncogenic mutations that drive cancer development and serve as diagnostic and prognostic biomarkers. Despite the increasing cancer burden in India, large-scale analyses of molecular landscapes, particularly gene fusions, have been relatively scarce. MATERIALS AND METHODS This retrospective …

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Comprehensive Genomic Characterization of 1,200 Samples across 25 Cancer Types of Indian Ethnicity

Elveera Saldanha, Raunak Kumar, Sreekanth Reddy Peddagangannagari, Priyanka Pange et autres

*Corresponding author : (e-mail: pratikchandrani@gmail.com).

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RET Alterations Differentiate Molecular Profile of Medullary Thyroid Cancer

Kumar Prabhash, Elveera Saldanha, Vijay Patil, Munita Bal et autres

PURPOSE Medullary thyroid cancer (MTC) is a rare cancer originating from parafollicular C cells of the thyroid gland. Therapeutically relevant alterations in MTC are predominantly reported in RET oncogene, and lower-frequency alterations are reported in KRAS and BRAF . Nevertheless, there is …

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Molecular insights from comprehensive genomic profiling data in advanced metastatic colorectal cancer in South Asian population: A retrospective observational study

Nusrath Fathima, Krithika Verma, Paridhy Vanniya Subramanyam, Nilesh Mukherjee et autres

ABSTRACT Background: An increase in colorectal cancer incidence has been reported in India, often presenting in advanced stages and resulting in poor survival. However, the genomic and therapeutic landscape is not well understood. Objective: The primary objective of the study was to …

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225P A novel multianalyte signature for stratifying Indian non-muscle invasive bladder cancer: A single center observational study

Sun P, Srihari Sharma, Rahul Pappala, D. Devi et autres

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Pan-cancer analysis of the spectrum of homologous recombination DNA repair (HRR) pathway genes in the Indian population: A retrospective observational study

Nasreen Parween, Trisha Dutta Gupta, Paridhy Vanniya Subramanyam, Nishtha Tanwar et autres

Background: Homologous recombinant repair (HRR) deficit and the associated sensitivity to poly (ADP-ribose) polymerase inhibitors (PARPi) has been well studied in breast, ovarian, prostate, and pancreatic cancers, but very little is known about it in other cancer types. Objectives: We sought to …

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Understanding the Impact of Population and Cancer Type on Tumor Mutation Burden Scores: A Comprehensive Whole-Exome Study in Cancer Patients From India

Nishtha Tanwar, Richa Malhotra, Aiswarya Padmaja Satheesh, Satya Prakash Khuntia et autres

PURPOSE: The purpose of this study was to understand the impact of population diversity and geographic variation on tumor mutation burden (TMB) scores across cancers and its implication on stratification of patients for immune checkpoint inhibitor (ICI) therapy. MATERIALS AND METHODS: This …

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An absolute approach to using whole exome DNA and RNA workflow for cancer biomarker testing

Richa Malhotra, Vyomesh Javle, Nishtha Tanwar, Pooja Gowda et autres

Introduction: The concept of personalized medicine in cancer has emerged rapidly with the advancement of genome sequencing and the identification of clinically relevant variants that contribute to disease prognosis and facilitates targeted therapy options. In this study, we propose to validate a …

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