Isabela Pedroza‐Pacheco

Abstract 4859: TMEM33 loss improves CD8+ T cell fitness and tumor control

Matthew Jackson, Tianming Zhao, Isabela Pedroza‐Pacheco, Amit Grover et autres

Abstract The Endoplasmic Reticulum (ER) is a critical immunomodulatory hub governing multiple processes relating to anti-tumor immunity. TMEM33 is an ER-resident membrane protein implicated in various ER-associated functions including cholesterol metabolism, calcium oscillations, and proteostasis. We previously reported TMEM33 as a negative …

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Subordinate Effect of -21M HLA-B Dimorphism on NK Cell Repertoire Diversity and Function in HIV-1 Infected Individuals of African Origin

Dimitra Peppa, Elia Moreno Cubero, Barton F. Haynes, Myron S. Cohen et autres

Natural Killer (NK) cells play an important role in antiviral defense and their potent effector function identifies them as key candidates for immunotherapeutic interventions in chronic viral infections. Their remarkable functional agility is achieved by virtue of a wide array of germline-encoded …

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RAB11FIP5 Expression and Altered Natural Killer Cell Function Are Associated with Induction of HIV Broadly Neutralizing Antibody Responses

M.A. Moody, G.D. Tomaras, Vaishnavi Venkat, Dimitra Peppa et autres

HIV-1 broadly neutralizing antibodies (bnAbs) are difficult to induce with vaccines but are generated in ∼50% of HIV-1-infected individuals. Understanding the molecular mechanisms of host control of bnAb induction is critical to vaccine design. Here, we performed a transcriptome analysis of blood …

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Immune perturbations in HIV-1–infected individuals who make broadly neutralizing antibodies

Kelly A. Soderberg, Persephone Borrow, D.C. Montefiori, KE Lloyd et autres

Induction of broadly neutralizing antibodies (bnAbs) is a goal of HIV-1 vaccine development. bnAbs occur in some HIV-1–infected individuals and frequently have characteristics of autoantibodies. We have studied cohorts of HIV-1–infected individuals who made bnAbs and compared them with those who did …

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Immune signature atlas of vaccines: learning from the good responders

Isabela Pedroza‐Pacheco, Andrew J. McMichael

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Harnessing CXCL13 in ovarian cancer

Elena Brenna, Isabela Pedroza‐Pacheco

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Inclusion of cGAMP within virus-like particle vaccines enhances their immunogenicity

Lise Chauveau, Anne Bridgeman, Tiong Kit Tan, Joe N. Frost et autres

Cyclic GMP-AMP (cGAMP) is an immunostimulatory molecule produced by cGAS that activates STING. cGAMP is an adjuvant when administered alongside antigens. cGAMP is also incorporated into enveloped virus particles during budding. Here, we investigate whether inclusion of cGAMP within viral vaccine vectors …

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Protein/AS01B vaccination elicits stronger, more Th2-skewed antigen-specific human T follicular helper cell responses than heterologous viral vectors

Carolyn M. Nielsen, Ane Ogbe, Isabela Pedroza‐Pacheco, Susanne E. Doeleman et autres

Interactions between B cells and CD4 + T follicular helper (Tfh) cells are key determinants of humoral responses. Using samples from clinical trials performed with the malaria vaccine candidate antigen Plasmodium falciparum merozoite protein (PfRH5), we compare the frequency, phenotype, and gene …

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Targeting autoantibodies in COVID-19

Isabela Pedroza‐Pacheco, Persephone Borrow

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RAB11FIP5-Deficient Mice Exhibit Cytokine-Related Transcriptomic Signatures

Dapeng Li, Todd Bradley, Derek W. Cain, Isabela Pedroza‐Pacheco et autres

Abstract Rab11 recycling endosomes are involved in immunological synaptic functions, but the roles of Rab11 family–interacting protein 5 (Rab11Fip5), one of the Rab11 effectors, in the immune system remain obscure. Our previous study demonstrated that RAB11FIP5 transcripts are significantly elevated in PBMCs …

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Pharmacological activation of the circadian component REV-ERB inhibits HIV-1 replication

Helene Borrmann, Rhianna Davies, Matthew Dickinson, Isabela Pedroza‐Pacheco et autres

Human immunodeficiency virus 1 (HIV-1) is a life-threatening pathogen that still lacks a curative therapy or vaccine. Despite the reduction in AIDS-related deaths achieved by current antiretroviral therapies, drawbacks including drug resistance and the failure to eradicate infection highlight the need to …

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Hypoxic microenvironment shapes HIV-1 replication and latency

Xiaodong Zhuang, Isabela Pedroza‐Pacheco, Isabel Nawroth, Anna E. Kliszczak et autres

Viral replication is defined by the cellular microenvironment and one key factor is local oxygen tension, where hypoxia inducible factors (HIFs) regulate the cellular response to oxygen. Human immunodeficiency virus (HIV) infected cells within secondary lymphoid tissues exist in a low-oxygen or …

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