Accès ouvert
2023
article
OpenAlex
Denise Naniche, G.D. Tomaras, N.A. Vandergrift, T.N. Denny et autres
Accurate HIV-1 incidence estimation is critical to the success of HIV-1 prevention strategies. Current assays are limited by high false recent rates (FRRs) in certain populations and a short mean duration of recent infection (MDRI). Dynamic early HIV-1 antibody response kinetics were …
us
(code pays fourni par la source)
Accès ouvert
2023
article
OpenAlex
M.A. Moody, G.D. Tomaras, Vaishnavi Venkat, Dimitra Peppa et autres
HIV-1 broadly neutralizing antibodies (bnAbs) are difficult to induce with vaccines but are generated in ∼50% of HIV-1-infected individuals. Understanding the molecular mechanisms of host control of bnAb induction is critical to vaccine design. Here, we performed a transcriptome analysis of blood …
us
(code pays fourni par la source)
Accès ouvert
2023
article
OpenAlex
B. Korber, Guojun Yang, T.B. Kepler, G.D. Tomaras et autres
Induction of broadly neutralizing antibodies (bnAbs) is a goal of HIV-1 vaccine development. Antibody 10E8, reactive with the distal portion of the membrane-proximal external region (MPER) of HIV-1 gp41, is broadly neutralizing. However, the ontogeny of distal MPER antibodies and the relationship …
us
(code pays fourni par la source)
Accès ouvert
2020
article
OpenAlex
Y. Yang, M.A. Moody, Hang Liao, J. Amos et autres
Background In acute HIV-1 infection (AHI) there are infectioninduced polyclonal shifts in blood and bone marrow Bcell subsets from naïve to memory cells and plasmablasts/ plasma cells (PCs) coupled with decreased numbers of naive B cells. To study the initial antibody response …
us
(code pays fourni par la source)